Urinary d-Glucaric Acid Excretion as a Measure of Hepatic Enzyme Induction in Man

1971 ◽  
Vol 40 (3) ◽  
pp. 10P-10P
Author(s):  
J. Hunter ◽  
J. D. Maxwell ◽  
M. Carrella ◽  
D. A. Stewart ◽  
Roger Williams
Keyword(s):  
Enzyme Induction ◽  
Acid Excretion ◽  
Hepatic Enzyme ◽  
Glucaric Acid

URINARY D-GLUCARIC-ACID EXCRETION AS A TEST FOR HEPATIC ENZYME INDUCTION IN MAN

The Lancet ◽  
1971 ◽  
Vol 297 (7699) ◽  
pp. 572-575 ◽  
Author(s):  
John Hunter ◽  
M. Carrella ◽  
J.D. Maxwell ◽  
D.A. Stewart ◽  
Roger Williams
Keyword(s):  
Enzyme Induction ◽  
Acid Excretion ◽  
Hepatic Enzyme ◽  
Glucaric Acid

D-GLUCARIC-ACID EXCRETION AS A TEST FOR HEPATIC ENZYME INDUCTION

The Lancet ◽  
1971 ◽  
Vol 298 (7714) ◽  
pp. 47 ◽  
Author(s):  
John Hunter ◽  
J.D. Maxwell ◽  
Roger Williams
Keyword(s):  
Enzyme Induction ◽  
Acid Excretion ◽  
Hepatic Enzyme ◽  
Glucaric Acid

Enzyme Induction and Serum and Lipoprotein Lipids: A Study of Glutethimide in Normal Subjects

1980 ◽  
Vol 58 (5) ◽  
pp. 419-421 ◽  
Author(s):  
C. H. Bolton ◽  
LYN Jackson ◽  
C. J. C. Roberts ◽  
M. Hartog
Keyword(s):  
Enzyme Induction ◽  
Time Course ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Low Density ◽  
Acid Excretion ◽  
Glucaric Acid

1. Serum and lipoprotein cholesterol and triglycerides were measured before, during and after the administration of glutethimide (500 mg daily) for 21 days to six healthy volunteer subjects. 2. Evidence of enzyme induction was provided by significant rises in d-glucaric acid excretion and antipyrine clearance. 3. Concentrations of total serum cholesterol, very-low-density-lipoprotein-, low-density-lipoprotein-and high-density-lipoprotein-cholesterol rose significantly during treatment. 4. The time course of these changes was delayed in comparison with the rise and fall in d-glucaric acid excretion. 5. There was no change in the triglyceride content of either whole serum or lipoprotein fractions at any time during the trial. 6. The study provides further evidence that enzyme-inducing agents cause a rise in certain lipid concentrations.

scholarly journals ETHOSUXIMIDE: LIVER ENZYME INDUCTION AND D-GLUCARIC ACID EXCRETION

1974 ◽  
Vol 1 (3) ◽  
pp. 249-252 ◽  
Author(s):  
J.C. GILBERT ◽  
A.K. SCOTT ◽  
D.B. GALLOWAY ◽  
J.C. PETRIE
Keyword(s):  
Liver Enzyme ◽  
Enzyme Induction ◽  
Acid Excretion ◽  
Glucaric Acid
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