Urinary D-glucaric acid excretion during rifampicin/isoniazid and anticonvulsant enzyme induction

1984 ◽  
Vol 35 (5) ◽  
pp. 710-715 ◽  
Author(s):  
Wayne Perry ◽  
Trevor C B Stamp
Keyword(s):  
Enzyme Induction ◽  
Acid Excretion ◽  
Glucaric Acid

URINARY D-GLUCARIC-ACID EXCRETION AS A TEST FOR HEPATIC ENZYME INDUCTION IN MAN

The Lancet ◽  
1971 ◽  
Vol 297 (7699) ◽  
pp. 572-575 ◽  
Author(s):  
John Hunter ◽  
M. Carrella ◽  
J.D. Maxwell ◽  
D.A. Stewart ◽  
Roger Williams
Keyword(s):  
Enzyme Induction ◽  
Acid Excretion ◽  
Hepatic Enzyme ◽  
Glucaric Acid

D-GLUCARIC-ACID EXCRETION AS A TEST FOR HEPATIC ENZYME INDUCTION

The Lancet ◽  
1971 ◽  
Vol 298 (7714) ◽  
pp. 47 ◽  
Author(s):  
John Hunter ◽  
J.D. Maxwell ◽  
Roger Williams
Keyword(s):  
Enzyme Induction ◽  
Acid Excretion ◽  
Hepatic Enzyme ◽  
Glucaric Acid

Enzyme Induction and Serum and Lipoprotein Lipids: A Study of Glutethimide in Normal Subjects

1980 ◽  
Vol 58 (5) ◽  
pp. 419-421 ◽  
Author(s):  
C. H. Bolton ◽  
LYN Jackson ◽  
C. J. C. Roberts ◽  
M. Hartog
Keyword(s):  
Enzyme Induction ◽  
Time Course ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Low Density ◽  
Acid Excretion ◽  
Glucaric Acid

1. Serum and lipoprotein cholesterol and triglycerides were measured before, during and after the administration of glutethimide (500 mg daily) for 21 days to six healthy volunteer subjects. 2. Evidence of enzyme induction was provided by significant rises in d-glucaric acid excretion and antipyrine clearance. 3. Concentrations of total serum cholesterol, very-low-density-lipoprotein-, low-density-lipoprotein-and high-density-lipoprotein-cholesterol rose significantly during treatment. 4. The time course of these changes was delayed in comparison with the rise and fall in d-glucaric acid excretion. 5. There was no change in the triglyceride content of either whole serum or lipoprotein fractions at any time during the trial. 6. The study provides further evidence that enzyme-inducing agents cause a rise in certain lipid concentrations.

scholarly journals ETHOSUXIMIDE: LIVER ENZYME INDUCTION AND D-GLUCARIC ACID EXCRETION

1974 ◽  
Vol 1 (3) ◽  
pp. 249-252 ◽  
Author(s):  
J.C. GILBERT ◽  
A.K. SCOTT ◽  
D.B. GALLOWAY ◽  
J.C. PETRIE
Keyword(s):  
Liver Enzyme ◽  
Enzyme Induction ◽  
Acid Excretion ◽  
Glucaric Acid

D-Glucaric acid and gamma-glutamyltransferase as indices of hepatic enzyme induction in pregnancy.

1977 ◽  
Vol 23 (3) ◽  
pp. 596-598 ◽  
Author(s):  
M Herzberg ◽  
E Tenenbaum ◽  
B Fishel ◽  
M H Wiener
Keyword(s):  
Enzyme Induction ◽  
First Trimester ◽  
Transferase Activity ◽  
Gamma Glutamyl Transferase ◽  
Acid Excretion ◽  
Glucaric Acid ◽  
Gamma Glutamyltransferase ◽  
Normal Limits ◽  
Glutamyl Transferase ◽  
In Pregnancy

Abstract Increased activity of hepatic microsomal enzymes can be evaluated by measuring D-glucaric acid excretion in urine and gamma-glutamyltransferase (EC 2.3.2.2) activity in serum. Aside from diverse foreign compounds, endogenous steroid hormones have been shown to be normal substrates of the microsomal enzyme system. Because there is an increase in steroid production in pregnancy, we sought to determine whether these indices of induction increase during pregnancy. In 90 women in various stages of pregnancy, all with normal kidney function, we measured glucaric acid excretion in urine and activity of the transferase in serum and in urine. Glucaric acid increased markedly during pregnancy, from 14.4 +/- 2.1 in the first trimester to 23.5 +/- 2.8 mumol of D-glucaro-1,4-lactone per gram of creatinine in the third trimester. We saw no correlation between glucaric acid excretion and the transferase activity in serum or urine. Activity of gamma-glutamyl-transferase remains within normal limits throughout pregnancy, which leaves doubt as to the value of this measurement in evaluating enzyme induction owing to endogenous steroids.

Sign in / Sign up

Export Citation Format

Share Document