scholarly journals Imeglimin Normalizes Glucose Tolerance and Insulin Sensitivity and Improves Mitochondrial Function in Liver of a High-Fat, High-Sucrose Diet Mice Model

Diabetes ◽  
2014 ◽  
Vol 64 (6) ◽  
pp. 2254-2264 ◽  
Author(s):  
Guillaume Vial ◽  
Marie-Agnès Chauvin ◽  
Nadia Bendridi ◽  
Annie Durand ◽  
Emmanuelle Meugnier ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Mitochondrial Function ◽  
Mice Model ◽  
High Fat ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

scholarly journals Anacardic acid mitigates liver fat accumulation and impaired glucose tolerance in mice fed a high‐fat and high‐sucrose diet

2020 ◽  
Vol 8 (2) ◽  
pp. 796-804 ◽  
Author(s):  
Sangwon Chung ◽  
Eun Ju Shin ◽  
Hyo‐Kyoung Choi ◽  
Jae Ho Park ◽  
Jin‐Taek Hwang
Keyword(s):  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Anacardic Acid ◽  
Liver Fat ◽  
High Fat ◽  
Fat Accumulation ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

Sandalwood seed oil improves insulin sensitivity in high-fat/high-sucrose diet-fed rats associated with altered intestinal microbiota and its metabolites

2021 ◽  
Author(s):  
Xiang Gao ◽  
Huijun Zhang ◽  
Kelei Li ◽  
Yan Shi ◽  
Xiao-fei Guo ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Intestinal Microbiota ◽  
Seed Oil ◽  
Current Work ◽  
High Fat ◽  
Ximenynic Acid ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
Santalum Spicatum ◽  
High Sucrose

Sandalwood seed oil (SSO), rich in ximenynic acid, is extracted from the seed kernels of santalum spicatum. The current work aimed to clarify the potential mechanisms of SSO in preventing insulin...

scholarly journals Effects of Sodium‐Glucose Linked Transporter 2 Inhibition With Ertugliflozin on Mitochondrial Function, Energetics, and Metabolic Gene Expression in the Presence and Absence of Diabetes Mellitus in Mice

2021 ◽  
Author(s):  
Dominique Croteau ◽  
Ivan Luptak ◽  
Jordan M. Chambers ◽  
Ion Hobai ◽  
Marcello Panagia ◽  
...  
Keyword(s):  
Mitochondrial Function ◽  
High Energy ◽  
Contractile Reserve ◽  
High Energy Phosphates ◽  
Cardiac Energetics ◽  
High Fat ◽  
Gene Sets ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

Background Inhibitors of the sodium‐glucose linked transporter 2 improve cardiovascular outcomes in patients with or without type 2 diabetes mellitus, but the effects on cardiac energetics and mitochondrial function are unknown. We assessed the effects of sodium‐glucose linked transporter 2 inhibition on mitochondrial function, high‐energy phosphates, and genes encoding mitochondrial proteins in hearts of mice with and without diet‐induced diabetic cardiomyopathy. Methods and Results Mice fed a control diet or a high‐fat, high‐sucrose diet received ertugliflozin mixed with the diet (0.5 mg/g of diet) for 4 months. Isolated mitochondria were assessed for functional capacity. High‐energy phosphates were assessed by 31 P nuclear magnetic resonance spectroscopy concurrently with contractile performance in isolated beating hearts. The high‐fat, high‐sucrose diet caused myocardial hypertrophy, diastolic dysfunction, mitochondrial dysfunction, and impaired energetic response, all of which were prevented by ertugliflozin. With both diets, ertugliflozin caused supernormalization of contractile reserve, as measured by rate×pressure product at high work demand. Likewise, the myocardial gene sets most enriched by ertugliflozin were for oxidative phosphorylation and fatty acid metabolism, both of which were enriched independent of diet. Conclusions Ertugliflozin not only prevented high‐fat, high‐sucrose–induced pathological cardiac remodeling, but improved contractile reserve and induced the expression of oxidative phosphorylation and fatty acid metabolism gene sets independent of diabetic status. These effects of sodium‐glucose linked transporter 2 inhibition on cardiac energetics and metabolism may contribute to improved structure and function in cardiac diseases associated with mitochondrial dysfunction, such as heart failure.

scholarly journals Effects of acute exposure to a high-fat, high-sucrose diet on gestational glucose tolerance and subsequent maternal health in mice†

2017 ◽  
Vol 96 (2) ◽  
pp. 435-445 ◽  
Author(s):  
Kathleen A. Pennington ◽  
Nicola van der Walt ◽  
Kelly E. Pollock ◽  
Omonseigho O. Talton ◽  
Laura C. Schulz
Keyword(s):  
Maternal Health ◽  
Glucose Tolerance ◽  
Acute Exposure ◽  
High Fat ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose
Sign in / Sign up

Export Citation Format

Share Document