Activities of 5-fluorouracil-metabolizing enzymes in human colorectal tumours and normal colorectal mucosa

1985 ◽  
Vol 13 (6) ◽  
pp. 1192-1193 ◽  
Author(s):  
PETER A. KOKLITIS ◽  
JERRY KELLEHER ◽  
RODERICK F. G. J. KING ◽  
GEOFFREY R. GILES
Keyword(s):  
Metabolizing Enzymes ◽  
Normal Colorectal Mucosa ◽  
Colorectal Mucosa ◽  
Colorectal Tumours

scholarly journals Protocol for the long‐term culture of human primary keratinocytes from the normal colorectal mucosa

2019 ◽  
Vol 234 (7) ◽  
pp. 9895-9905 ◽  
Author(s):  
Elena Torreggiani ◽  
Marika Rossini ◽  
Ilaria Bononi ◽  
Silvia Pietrobon ◽  
Elisa Mazzoni ◽  
...  
Keyword(s):  
Primary Keratinocytes ◽  
Long Term Culture ◽  
Normal Colorectal Mucosa ◽  
Colorectal Mucosa ◽  
Human Primary Keratinocytes

scholarly journals DNA methylation within the normal colorectal mucosa is associated with pathway-specific predisposition to cancer

Oncogene ◽  
2009 ◽  
Vol 29 (11) ◽  
pp. 1653-1662 ◽  
Author(s):  
D L Worthley ◽  
V L J Whitehall ◽  
R L Buttenshaw ◽  
N Irahara ◽  
S A Greco ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Normal Colorectal Mucosa ◽  
Colorectal Mucosa

scholarly journals Effects of supplemental calcium and vitamin D on the APC/β-catenin pathway in the normal colorectal mucosa of colorectal adenoma patients

2016 ◽  
Vol 56 (2) ◽  
pp. 412-424 ◽  
Author(s):  
Siyu Liu ◽  
Elizabeth L. Barry ◽  
John A. Baron ◽  
Robin E. Rutherford ◽  
March E. Seabrook ◽  
...  
Keyword(s):  
Vitamin D ◽  
Colorectal Adenoma ◽  
Normal Colorectal Mucosa ◽  
Colorectal Mucosa ◽  
Supplemental Calcium

Classification of normal colorectal mucosa and adenocarcinoma by morphometry

1987 ◽  
Vol 11 (9) ◽  
pp. 901-911 ◽  
Author(s):  
P.W. HAMILTON ◽  
D.C. ALLEN ◽  
P.C.H. WATT ◽  
C.C. PATTERSON ◽  
J.D. BIGGART
Keyword(s):  
Normal Colorectal Mucosa ◽  
Colorectal Mucosa

scholarly journals W1737 Advanced Colorectal Neoplasia is Associated With Telomere Shortening Within the Normal Colorectal Mucosa

2010 ◽  
Vol 138 (5) ◽  
pp. S-730
Author(s):  
Daniel L. Worthley ◽  
Nathan O'Callaghan ◽  
Shuji Ogino ◽  
Natsumi Irahara ◽  
Vicki L. Whitehall ◽  
...  
Keyword(s):  
Colorectal Neoplasia ◽  
Telomere Shortening ◽  
Normal Colorectal Mucosa ◽  
Colorectal Mucosa ◽  
Advanced Colorectal Neoplasia

scholarly journals Altered GalNAc-α-2,6-sialylation Compartments for Mucin-associated Sialyl-Tn Antigen in Colorectal Adenoma and Adenocarcinoma

2001 ◽  
Vol 49 (12) ◽  
pp. 1581-1591 ◽  
Author(s):  
Fuan Wang ◽  
Masamichi Goto ◽  
Young S. Kim ◽  
Michiyo Higashi ◽  
Kohzoh Imai ◽  
...  
Keyword(s):  
Golgi Apparatus ◽  
Colorectal Adenoma ◽  
Colorectal Adenocarcinoma ◽  
Tumor Biology ◽  
Electron Microscopic ◽  
Normal Colorectal Mucosa ◽  
Colorectal Mucosa ◽  
Sialyl Tn Antigen ◽  
Sialyl Tn

Sialyl-Tn (STn), a mucin-associated disaccharide antigen carried by apomucins such as MUC2, plays an important role in tumor biology. However, little is known about the subcellular localization and compartments involved in STn synthesis. In this study we used immunoelectron microscopy to localize STn and MUC2 apomucin in human colorectal tissues. MUC2 apomucin was localized predominantly in the rough endoplasmic reticulum (RER) in normal colorectal mucosa ( n=6), colorectal adenoma ( n=8), and colorectal adenocarcinoma ( n=10). STn, recognized by monoclonal antibody TKH2, was not readily detectable in normal colorectal mucosa but becomes manifest in both trans-Golgi apparatus and mucin droplets in colorectal adenoma. In colorectal adenocarcinoma, STn was localized not only in late but also in early Golgi compartments, and particularly in some RER lumens. Furthermore, electron microscopic in situ hybridization revealed that gold particles representing MUC2 mRNA are primarily localized over the RER. Our findings indicate that in colorectal adenoma STn sialylation takes place in the trans-Golgi apparatus, whereas in colorectal cancer STn sialylation occurs in all the Golgi compartments and in the RER.

Differences between transcriptional gene expression profile of colorectal adenomas and normal colorectal mucosa

2006 ◽  
Vol 38 ◽  
pp. S110
Author(s):  
J. Sabates Bellver ◽  
M. de Palo ◽  
M. Menigatti ◽  
V. Gomes ◽  
A. Pastorelli ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Colorectal Adenomas ◽  
Normal Colorectal Mucosa ◽  
Colorectal Mucosa
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