scholarly journals Effects of supplemental calcium and vitamin D on the APC/β-catenin pathway in the normal colorectal mucosa of colorectal adenoma patients

2016 ◽  
Vol 56 (2) ◽  
pp. 412-424 ◽  
Author(s):  
Siyu Liu ◽  
Elizabeth L. Barry ◽  
John A. Baron ◽  
Robin E. Rutherford ◽  
March E. Seabrook ◽  
...  
Keyword(s):  
Vitamin D ◽  
Colorectal Adenoma ◽  
Normal Colorectal Mucosa ◽  
Colorectal Mucosa ◽  
Supplemental Calcium

scholarly journals Effects of supplemental vitamin D and calcium on markers of proliferation, differentiation, and apoptosis in the normal colorectal mucosa of colorectal adenoma patients

PLoS ONE ◽  
2018 ◽  
Vol 13 (12) ◽  
pp. e0208762 ◽  
Author(s):  
Yasheen Gao ◽  
Caroline Y. Um ◽  
Veronika Fedirko ◽  
Robin E. Rutherford ◽  
March E. Seabrook ◽  
...  
Keyword(s):  
Vitamin D ◽  
Colorectal Adenoma ◽  
Normal Colorectal Mucosa ◽  
Colorectal Mucosa ◽  
Supplemental Vitamin

scholarly journals Inflammation Modulation by Vitamin D and Calcium in the Morphologically Normal Colorectal Mucosa of Colorectal Adenoma Patients in a Clinical Trial

2020 ◽  
pp. canprevres.0140.2020
Author(s):  
David Corley Gibbs ◽  
Veronika Fedirko ◽  
John A. Baron ◽  
Elizabeth L. Barry ◽  
W. Dana Flanders ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Vitamin D ◽  
Colorectal Adenoma ◽  
Normal Colorectal Mucosa ◽  
Colorectal Mucosa

scholarly journals Altered GalNAc-α-2,6-sialylation Compartments for Mucin-associated Sialyl-Tn Antigen in Colorectal Adenoma and Adenocarcinoma

2001 ◽  
Vol 49 (12) ◽  
pp. 1581-1591 ◽  
Author(s):  
Fuan Wang ◽  
Masamichi Goto ◽  
Young S. Kim ◽  
Michiyo Higashi ◽  
Kohzoh Imai ◽  
...  
Keyword(s):  
Golgi Apparatus ◽  
Colorectal Adenoma ◽  
Colorectal Adenocarcinoma ◽  
Tumor Biology ◽  
Electron Microscopic ◽  
Normal Colorectal Mucosa ◽  
Colorectal Mucosa ◽  
Sialyl Tn Antigen ◽  
Sialyl Tn

Sialyl-Tn (STn), a mucin-associated disaccharide antigen carried by apomucins such as MUC2, plays an important role in tumor biology. However, little is known about the subcellular localization and compartments involved in STn synthesis. In this study we used immunoelectron microscopy to localize STn and MUC2 apomucin in human colorectal tissues. MUC2 apomucin was localized predominantly in the rough endoplasmic reticulum (RER) in normal colorectal mucosa ( n=6), colorectal adenoma ( n=8), and colorectal adenocarcinoma ( n=10). STn, recognized by monoclonal antibody TKH2, was not readily detectable in normal colorectal mucosa but becomes manifest in both trans-Golgi apparatus and mucin droplets in colorectal adenoma. In colorectal adenocarcinoma, STn was localized not only in late but also in early Golgi compartments, and particularly in some RER lumens. Furthermore, electron microscopic in situ hybridization revealed that gold particles representing MUC2 mRNA are primarily localized over the RER. Our findings indicate that in colorectal adenoma STn sialylation takes place in the trans-Golgi apparatus, whereas in colorectal cancer STn sialylation occurs in all the Golgi compartments and in the RER.

scholarly journals Effects of Supplemental Calcium and Vitamin D on Expression of Toll-Like Receptors and Phospho-IKKα/β in the Normal Rectal Mucosa of Colorectal Adenoma Patients

2018 ◽  
Vol 11 (11) ◽  
pp. 707-716 ◽  
Author(s):  
Rebecca Hodge ◽  
Hannah B. Mandle ◽  
Stephen Ray ◽  
Sonia Tandon ◽  
Meaghan Peterson ◽  
...  
Keyword(s):  
Vitamin D ◽  
Colorectal Adenoma ◽  
Rectal Mucosa ◽  
Toll Like Receptors ◽  
Supplemental Calcium
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