Differential expression of HLA-DR, HLA-DP, HLA-DQ and associated invariant chain (Ii) in normal colorectal mucosa, adenoma and carcinoma

1988 ◽  
Vol 412 (4) ◽  
pp. 315-322 ◽  
Author(s):  
Theodora Degener ◽  
Frank Momburg ◽  
Peter M�ller
Keyword(s):  
Differential Expression ◽  
Invariant Chain ◽  
Normal Colorectal Mucosa ◽  
Colorectal Mucosa ◽  
Hla Dr ◽  
Hla Dq

Differential expression of HLA-DR and HLA-DQ antigens on normal cells of the myelomonocytic lineage

2008 ◽  
Vol 26 (5) ◽  
pp. 310-317 ◽  
Author(s):  
M. C. Alonso ◽  
C. Navarrete ◽  
R. Solana ◽  
A. Torres ◽  
J. Pena ◽  
...  
Keyword(s):  
Differential Expression ◽  
Normal Cells ◽  
Hla Dr ◽  
Hla Dq

scholarly journals HLA-DP, HLA-DQ, and HLA-DR Have Different Requirements for Invariant Chain and HLA-DM

2010 ◽  
Vol 285 (52) ◽  
pp. 40800-40808 ◽  
Author(s):  
Marcel van Lith ◽  
Rosanna M. McEwen-Smith ◽  
Adam M. Benham
Keyword(s):  
Invariant Chain ◽  
Hla Dr ◽  
Hla Dq

First report on the antibody verification of HLA-DR, HLA-DQ and HLA-DP epitopes recorded in the HLA Epitope Registry

2014 ◽  
Vol 75 (11) ◽  
pp. 1097-1103 ◽  
Author(s):  
Rene J. Duquesnoy ◽  
Marilyn Marrari ◽  
Anat R. Tambur ◽  
Arend Mulder ◽  
Luiz Cláudio Demes da Mata Sousa ◽  
...  
Keyword(s):  
First Report ◽  
Hla Dr ◽  
Hla Dq

scholarly journals Cytokines in chronic inflammatory arthritis. IV. Granulocyte/macrophage colony-stimulating factor-mediated induction of class II MHC antigen on human monocytes: a possible role in rheumatoid arthritis.

1989 ◽  
Vol 170 (3) ◽  
pp. 865-875 ◽  
Author(s):  
J M Alvaro-Gracia ◽  
N J Zvaifler ◽  
G S Firestein
Keyword(s):  
Rheumatoid Arthritis ◽  
Class Ii ◽  
Tnf Alpha ◽  
Blood Monocytes ◽  
Ifn Gamma ◽  
Normal Peripheral Blood ◽  
Gm Csf ◽  
Hla Dr ◽  
Class Ii Mhc ◽  
Hla Dq

Granulocyte/macrophage CSF (GM-CSF) has recently been identified in rheumatoid arthritis (RA) synovial effusions. To study a potential role for GM-CSF and other cytokines on the induction of HLA-DR expression on monocytes and synovial macrophages, we analyzed the relative ability of recombinant human cytokines to induce the surface expression of class II MHC antigens on normal peripheral blood monocytes by FACS analysis. GM-CSF (800 U/ml) (mean fluorescence channel 2.54 +/- 0.33 times the control, p less than 0.001) and IFN-gamma (100 U/ml) (5.14 +/- 0.60, p less than 0.001) were the most potent inducers of HLA-DR. TNF-alpha and IL-4 also increased HLA-DR expression, although to a lesser degree [1.31 +/- 0.06 (p less than 0.02) and 1.20 +/- 0.03 (p less than 0.01), respectively]. IL-1 (40 U/ml), IL-2 (10 ng/ml), IL-3 (50 U/ml), IL-6 (100 U/ml), and CSF-1 (1,000 U/ml) did not affect surface HLA-DR density. GM-CSF also increased HLA-DR mRNA expression and surface HLA-DQ expression, but decreased CD14 (a monocyte/macrophage antigen) expression. The effect of GM-CSF on HLA-DR was not mediated by the generation of IFN-gamma in vitro because it was not blocked by anti-IFN-gamma mAb. GM-CSF was additive with IL-4 and low amounts (less than 3 U/ml) of IFN-gamma and synergistic with TNF-alpha. Because we have recently reported that supernatants of cultured RA synovial cells produce a non-IFN-gamma factor that induces HLA-DR on monocytes, we then attempted to neutralize this factor with specific anti-GM-CSF mAb. Four separate synovial tissue supernatants were studied, and the antibody neutralized the HLA-DR-inducing factor in each (p less than 0.01).

INTRACELLULAR AND CELL SURFACE MAPPING OF HLA DR IN THE PRESENCE AND ABSENCE OF THE INVARIANT CHAIN

1997 ◽  
Vol 25 (2) ◽  
pp. 259S-259S ◽  
Author(s):  
Kathy Triantafilou ◽  
Keith M. Wilson ◽  
Nelson Fernandez
Keyword(s):  
Cell Surface ◽  
Invariant Chain ◽  
Surface Mapping ◽  
Hla Dr ◽  
Presence And Absence
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