The Effects of Fatty Acid Concentration on Esterification in Liver and Adipose Tissue

1973 ◽  
Vol 1 (1) ◽  
pp. 299-302 ◽  
Author(s):  
THOMAS DELAHUNTY ◽  
WM. CLAYTON LOVE
1968 ◽  
Vol 106 (3) ◽  
pp. 677-682 ◽  
Author(s):  
Sheila Otway ◽  
D S Robinson

1. The concentration of triglyceride fatty acid in the plasma of the pregnant rat rises to a maximum 2–4 days before parturition. Thereafter there is a rapid decline in the concentration to near normal values at parturition. 2. A similar increase occurs in animals fed on a diet low in fat. There is no increase in food consumption at the time when the triglyceride fatty acid concentration in the plasma is at its peak. 3. Rates of entry of triglyceride fatty acid into the blood during pregnancy have been estimated from the rate of accumulation of triglyceride in the plasma of animals injected with a non-ionic detergent, Triton. A progressive increase occurs in the entry rate as the body weight increases throughout pregnancy. Expressed per constant body weight, the entry rate does not change significantly. 4. Adipose-tissue clearing-factor lipase activity is low at the time when the plasma triglyceride fatty acid concentration is raised. Activity of the enzyme in heart, lung and diaphragm is unchanged. 5. It is suggested that the ‘lipaemia of pregnancy’ may be due to diminished uptake of triglyceride fatty acids by adipose tissue, and, further, that the disappearance of the lipaemia may be due to increased uptake of triglyceride fatty acids by the mammary gland.


1984 ◽  
Vol 114 (10) ◽  
pp. 1834-1842 ◽  
Author(s):  
Kent L. Erickson ◽  
Deborah S. Schlanger ◽  
Dorothy A. Adams ◽  
David R. Fregeau ◽  
Judith S. Stern

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Pratip Rana ◽  
Dexter N. Dean ◽  
Edward D. Steen ◽  
Ashwin Vaidya ◽  
Vijayaraghavan Rangachari ◽  
...  

2020 ◽  
Author(s):  
Takio Inatomi

AbstractConstipation, a common health problem, causes discomfort and affects quality of life. This study aimed to evaluate the potential effect of probiotics on loperamide (LP)-induced constipation in Sprague-Dawley (SD) rats, a well-established animal model of spastic constipation. In total, 100 male SD rats (age, 8 weeks; Japan SLC, Inc., Hamamatsu, Japan) were used in the experiments following a 12-day acclimatisation period. They were randomly divided into two treatment groups (groups 1 and 2) of 50 rats each. Spastic constipation was induced via oral administration of LP (3 mg/kg) for 6 days 1 hour before the administration of each test compound. Similarly, a probiotics solution (4 ml/kg body weight) was orally administered to the rats once a day for 6 days in group 2. In group 1, phosphate buffer solution was orally administered once a day for 6 days 1 hour after each LP administration. The changes in body weight, faecal parameters, short-chain fatty acid concentration in faeces, and faecal immunoglobulin (Ig)-A concentration were recorded. In the present study, the oral administration of probiotics improved faecal parameters, short-chain fatty acid concentration in faeces, and faecal IgA concentration. Our results indicate that probiotics increase the levels of intestinal short-chain fatty acids, especially butyric acid, thereby improving constipation and intestinal immunity.


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