scholarly journals TP53 rs1042522 C>G polymorphism and Wilms tumor susceptibility in Chinese children: a four-center case–control study

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Peng Liu ◽  
Zhenjian Zhuo ◽  
Wenya Li ◽  
Jiwen Cheng ◽  
Haixia Zhou ◽  
...  
Keyword(s):  
Significant Relationship ◽  
Wilms Tumor ◽  
Tp53 Gene ◽  
Chinese Children ◽  
Logistic Regression Models ◽  
Tumor Susceptibility ◽  
Tumor Risk ◽  
Larger Sample ◽  
Control Study

Abstract Wilms tumor is the most common renal malignancy that occurs in children. TP53 gene is considered as a tumor-suppressing gene through controlling cell growth. TP53 gene rs1042522 C>G (Arg72Pro) polymorphism is widely investigated in various types of cancers. However, it is not established if TP53 rs1042522 C>G polymorphism is a candidate variant for Wilms tumor risk. The aim of the study was to determine whether TP53 rs1042522 C>G polymorphism is responsible for the risk of Wilms tumor in Chinese children. All subjects (355 cases and 1070 controls) from four centers of China were genotyped for rs1042522 C>G polymorphism. The effect of rs1042522 C>G polymorphism on Wilms tumor prevalence was analyzed using logistic regression models. We failed to detect a significant relationship between rs1042522 C>G polymorphism and Wilms tumor risk. Further stratification analysis also could not detect a significant relationship. We conclude that TP53 rs1042522 C>G polymorphism might not have enough impact on the risk of Wilms tumor. More validation study with larger sample size will be required to better define the role of TP53 rs1042522 C>G polymorphism in Wilms tumor risk.

METTL3 polymorphisms and Wilms tumor susceptibility in Chinese children: A five‐center case–control study

2020 ◽  
Vol 22 (11) ◽  
Author(s):  
Ao Lin ◽  
Mingming Zhou ◽  
Rui‐Xi Hua ◽  
Jiao Zhang ◽  
Haixia Zhou ◽  
...  
Keyword(s):  
Case Control Study ◽  
Wilms Tumor ◽  
Case Control ◽  
Chinese Children ◽  
Tumor Susceptibility ◽  
Control Study

scholarly journals AURKA rs8173 G>C Polymorphism Decreases Wilms Tumor Risk in Chinese Children

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Tongyi Lu ◽  
Li Li ◽  
Jinhong Zhu ◽  
Jiabin Liu ◽  
Ao Lin ◽  
...  
Keyword(s):  
Haplotype Analysis ◽  
Wilms Tumor ◽  
Clinical Stage ◽  
Common Type ◽  
Chinese Children ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Tumor Susceptibility ◽  
Tumor Risk ◽  
Strength Of Association

Wilms tumor is the most common type of renal malignancy in children. Previous studies have demonstrated that single nucleotide polymorphisms (SNPs) in the AURKA gene could predispose to several human malignancies. We recruited 145 cases and 531 cancer-free controls to investigate whether AURKA gene variants modify Wilms tumor susceptibility. Three AURKA SNPs (rs1047972 C>T, rs2273535 T>A, and rs8173 G>C) were genotyped by the Taqman methodology. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of association between AURKA SNPs and Wilms tumor risk. We found that only the rs8173 G>C polymorphism was significantly associated with Wilms tumor risk (GC vs. GG: adjusted OR (AOR) = 0.50, 95% CI = 0.35–0.73, P=0.0002; GC/CC vs. GG: AOR = 0.60, 95% CI = 0.42–0.88, P=0.008). Stratification analysis revealed that rs8173 GC/CC genotypes were associated with Wilms tumor risk among children aged >18 months (AOR = 0.56, 95% CI = 0.34–0.93, P=0.024), male children (AOR = 0.54, 95% CI = 0.33–0.90, P=0.017), and children with clinical stage III + IV diseases (AOR = 0.56, 95% CI = 0.35–0.90, P=0.017). Haplotype analysis indicated that the CAG haplotype was significantly associated with increased Wilms tumor risk. In conclusion, our findings indicated that the AURKA rs8173 G>C polymorphism was associated with decreased Wilms tumor risk in Chinese children.

YTHDC1 gene polymorphisms and Wilms tumor susceptibility in Chinese children: A five-center case-control study

Gene ◽  
2021 ◽  
Vol 783 ◽  
pp. 145571
Author(s):  
Ao Lin ◽  
Rui-Xi Hua ◽  
Mingming Zhou ◽  
Wen Fu ◽  
Jiao Zhang ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Case Control Study ◽  
Wilms Tumor ◽  
Case Control ◽  
Chinese Children ◽  
Tumor Susceptibility ◽  
Control Study

scholarly journals MYC gene associated polymorphisms and Wilms tumor risk in Chinese children: a four-center case-control study

2019 ◽  
Vol 7 (18) ◽  
pp. 475-475 ◽  
Author(s):  
Jiabin Liu ◽  
Rui-Xi Hua ◽  
Wen Fu ◽  
Jinhong Zhu ◽  
Wei Jia ◽  
...  
Keyword(s):  
Case Control Study ◽  
Wilms Tumor ◽  
Case Control ◽  
Chinese Children ◽  
Tumor Risk ◽  
Myc Gene ◽  
Control Study

scholarly journals H19 gene polymorphisms and Wilms tumor risk in Chinese children: a four-center case-control study

2020 ◽  
Author(s):  
Wenya Li ◽  
Rui-Xi Hua ◽  
Mi Wang ◽  
Da Zhang ◽  
Jinhong Zhu ◽  
...  
Keyword(s):  
Case Control Study ◽  
Wilms Tumor ◽  
Genetic Variations ◽  
Nucleotide Polymorphisms ◽  
Predisposing Factor ◽  
Tumor Susceptibility ◽  
Tumor Risk ◽  
Male Patients ◽  
Stratified Analysis ◽  
Control Study

Abstract Background Wilms tumor is the most common pediatric renal cancer. However, genetic bases behind Wilms tumor remain largely unknown. H19 is a critical maternally imprinted gene. Previous studies indicated that nucleotide polymorphisms (SNPs) in the H19 can modify the risk of several human malignancies. Epigenetic errors at the H19 locus lead to biallele silencing in Wilms tumors. Genetic variations in the H19 may be related to Wilms tumor susceptibility. Methods We conducted a four-center study to investigate whether H19 SNPs was a predisposing factor to Wilms tumor. Three polymorphisms in the H19 (rs2839698 G>A, rs3024270 C>G, rs217727 G>A) were genotyped in 355 cases and 1070 cancer-free controls, using Taqman method. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the associations. Results We found that all of these three polymorphisms were significantly associated with Wilms tumor risk alterations. Carriers of 1, 2 and 1-2 risk genotypes were inclined to develop Wilms tumor compared with those without risk genotype (adjusted OR=1.36, 95% CI=1.02-1.80, P=0.037; adjusted OR=1.84, 95% CI=1.27-2.67, P=0.001; adjusted OR=1.50, 95% CI=1.17-1.92, P=0.002, respectively). The stratified analysis further revealed that rs2839698 AA, rs217727 AA, and 1-2 risk genotypes could strongly increase Wilms tumor risk among male patients above 18 months of age.Conclusion Our findings indicate that genetic variations in the H19 may confer Wilms tumor risk.

scholarly journals The association of miR34b/c and TP53 gene polymorphisms with Wilms tumor risk in Chinese children

2020 ◽  
Vol 40 (2) ◽  
Author(s):  
Juxiang Wang ◽  
Susu Lou ◽  
Xiaokai Huang ◽  
Yixiao Mo ◽  
Zhen Wang ◽  
...  
Keyword(s):  
Wilms Tumor ◽  
Clinical Stage ◽  
Tp53 Gene ◽  
Effect Analysis ◽  
Tumor Susceptibility ◽  
Downstream Target ◽  
Functional Polymorphisms ◽  
Tumor Risk ◽  
Downstream Target Gene ◽  
Transcription Factor P53

Abstract Wilms tumor is the most common pediatric malignancy in the kidney. The miR34b/c is a downstream target gene of the transcription factor p53. The important role of TP53 mutations, the methylation of miR34b/c, and the interaction between these two molecules in tumorigenesis have been well documented. Due to the biological connection between p53 and miR34b/c, in the present study, we investigated the association between polymorphisms in these two molecules and Wilms tumor susceptibility through genotyping two important functional polymorphisms (miR34b/c rs4938723 T>C and TP53 rs1042522 C>G) in 183 cases and 603 controls. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) derived from the logistic regression analysis were used to assess the correlation of miR34b/c rs4938723 and TP53 rs1042522 polymorphisms with Wilms tumor risk. Our results indicated that the association of miR34b/c rs4938723 and TP53 rs1042522 polymorphisms with Wilms tumor susceptibility was not statistically significant. Stratified analysis by age, gender, and clinical stage, as well as combined effect analysis were also performed, yet, no significant association was found. In conclusion, our study indicated a lack of association between the two selected polymorphisms and Wilms tumor susceptibility. Our findings need to be verified in studies with larger sample size in the future.

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