METTL3 polymorphisms and Wilms tumor susceptibility in Chinese children: A five‐center case–control study

2020 ◽  
Vol 22 (11) ◽  
Author(s):  
Ao Lin ◽  
Mingming Zhou ◽  
Rui‐Xi Hua ◽  
Jiao Zhang ◽  
Haixia Zhou ◽  
...  
Keyword(s):  
Case Control Study ◽  
Wilms Tumor ◽  
Case Control ◽  
Chinese Children ◽  
Tumor Susceptibility ◽  
Control Study

YTHDC1 gene polymorphisms and Wilms tumor susceptibility in Chinese children: A five-center case-control study

Gene ◽  
2021 ◽  
Vol 783 ◽  
pp. 145571
Author(s):  
Ao Lin ◽  
Rui-Xi Hua ◽  
Mingming Zhou ◽  
Wen Fu ◽  
Jiao Zhang ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Case Control Study ◽  
Wilms Tumor ◽  
Case Control ◽  
Chinese Children ◽  
Tumor Susceptibility ◽  
Control Study

scholarly journals MYC gene associated polymorphisms and Wilms tumor risk in Chinese children: a four-center case-control study

2019 ◽  
Vol 7 (18) ◽  
pp. 475-475 ◽  
Author(s):  
Jiabin Liu ◽  
Rui-Xi Hua ◽  
Wen Fu ◽  
Jinhong Zhu ◽  
Wei Jia ◽  
...  
Keyword(s):  
Case Control Study ◽  
Wilms Tumor ◽  
Case Control ◽  
Chinese Children ◽  
Tumor Risk ◽  
Myc Gene ◽  
Control Study

scholarly journals TP53 rs1042522 C>G polymorphism and Wilms tumor susceptibility in Chinese children: a four-center case–control study

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Peng Liu ◽  
Zhenjian Zhuo ◽  
Wenya Li ◽  
Jiwen Cheng ◽  
Haixia Zhou ◽  
...  
Keyword(s):  
Significant Relationship ◽  
Wilms Tumor ◽  
Tp53 Gene ◽  
Chinese Children ◽  
Logistic Regression Models ◽  
Tumor Susceptibility ◽  
Tumor Risk ◽  
Larger Sample ◽  
Control Study

Abstract Wilms tumor is the most common renal malignancy that occurs in children. TP53 gene is considered as a tumor-suppressing gene through controlling cell growth. TP53 gene rs1042522 C>G (Arg72Pro) polymorphism is widely investigated in various types of cancers. However, it is not established if TP53 rs1042522 C>G polymorphism is a candidate variant for Wilms tumor risk. The aim of the study was to determine whether TP53 rs1042522 C>G polymorphism is responsible for the risk of Wilms tumor in Chinese children. All subjects (355 cases and 1070 controls) from four centers of China were genotyped for rs1042522 C>G polymorphism. The effect of rs1042522 C>G polymorphism on Wilms tumor prevalence was analyzed using logistic regression models. We failed to detect a significant relationship between rs1042522 C>G polymorphism and Wilms tumor risk. Further stratification analysis also could not detect a significant relationship. We conclude that TP53 rs1042522 C>G polymorphism might not have enough impact on the risk of Wilms tumor. More validation study with larger sample size will be required to better define the role of TP53 rs1042522 C>G polymorphism in Wilms tumor risk.

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