scholarly journals Development of multiple activities of UDP-glucuronyltransferase in human liver

1987 ◽  
Vol 243 (3) ◽  
pp. 859-861 ◽  
Author(s):  
J E A Leakey ◽  
R Hume ◽  
B Burchell
Keyword(s):  
Rhesus Monkey ◽  
Substrate Specificity ◽  
Human Liver ◽  
Adult Human

UDP-glucuronyltransferase activities towards eight substrates were assayed in samples of foetal, term and adult human liver. Activities towards bilirubin, androsterone, testosterone, 1-naphthol, 4-nitrophenol and 2-aminophenol were present in foetal and term liver samples at less than 14% of adult values, whereas activity towards 5-hydroxytryptamine was present in foetal and term liver at 109 and 121% of adult values respectively. Thus a ‘foetal’ form of UDP-glucuronyltransferase may exist in human liver that is more restricted in substrate specificity than are those of the rat or rhesus monkey.

EpCam-specific Gold Nanoparticles for Detection, Live-imaging and Rapid Enrichment of Adult Human Liver Progenitor Cells

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
N Fekete-Drimusz ◽  
J de la Roche ◽  
F Vondran ◽  
CL Sajti ◽  
MP Manns ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Progenitor Cells ◽  
Human Liver ◽  
Live Imaging ◽  
Adult Human

scholarly journals Adult human liver contains intermediate-type proteasomes with different enzymatic properties

2014 ◽  
Vol 13 (4) ◽  
pp. 429-438 ◽  
Author(s):  
Sabrina Gohlke ◽  
Alexander Kloβ ◽  
Michael Tsokos ◽  
Kathrin Textoris-Taube ◽  
Christin Keller ◽  
...  
Keyword(s):  
Human Liver ◽  
Enzymatic Properties ◽  
Intermediate Type ◽  
Adult Human

Highly efficient establishment of immortalized cells from adult human liver

1995 ◽  
Vol 17 (2) ◽  
pp. 83-89 ◽  
Author(s):  
A. M. A. Pfeifer ◽  
K. Mace ◽  
Y. Tromvoukis ◽  
M. M. Lipsky
Keyword(s):  
Human Liver ◽  
Adult Human ◽  
Highly Efficient ◽  
Immortalized Cells

scholarly journals Substrate Specificity and Ligand Interactions of CYP26A1, the Human Liver Retinoic Acid Hydroxylase

2011 ◽  
Vol 80 (2) ◽  
pp. 228-239 ◽  
Author(s):  
Jayne E. Thatcher ◽  
Brian Buttrick ◽  
Scott A. Shaffer ◽  
Jakob A. Shimshoni ◽  
David R. Goodlett ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Substrate Specificity ◽  
Human Liver ◽  
Ligand Interactions

scholarly journals Conjugated and unconjugated bilirubins in bile of humans and rhesus monkeys. Structure of adult human and rhesus-monkey bilirubins compared with dog bilirubins

1977 ◽  
Vol 167 (3) ◽  
pp. 535-548 ◽  
Author(s):  
S G Blumenthal ◽  
D B Taggart ◽  
R Ikeda ◽  
B H Ruebner ◽  
D E Bergstrom
Keyword(s):  
Chemical Composition ◽  
Gall Bladder ◽  
Rhesus Monkey ◽  
Rhesus Monkeys ◽  
Glucuronic Acid ◽  
Unknown Compound ◽  
Adult Human ◽  
Adult Humans ◽  
Technical Modifications ◽  
Working Day

1. Bilirubin-IXalpha, -IXalpha diglucuronide, -IXalpha monoglucuronide, -IXalpha monoglucoside -IXalpha monoxyloside, a bilirubin-IXalpha diconjugate containing glucose and another unknown compound, and bilirubin-IXbeta are present in gall-bladder bile of adult human, rhesus monkey and dog. Dog bile normally also contains other bilirubin-IXalpha diconjugates, i.e. compounds containing two conjugating sugars such as glucuronic acid and glucose, glucuronic acid and xylose and glucose xylose. 2. Azopigments alphaF, alphaO, alpha2, alpha3, betax and delta derived from human and rhesus-monkey bilirubins are identical in their chemical composition with those obtained from the dog. 3. Azopigments alphaF and betax found in diazotized biles of adult humans, rhesus monkeys and dogs are products of unconjugated bilirubin-IXbeta. 4. Technical modifications of previously published procedures [Heirwegh, Fevery, Michiels, Van Hees & Compernolle, (1975) Biochem. J. 145, 185-199] were introduced which make it possible to separate the bilirubins, diazotize the separated bilirubins, extract the azopigments and chromatograph them in one working day (6-8h).

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