scholarly journals A study of vitamin B12 protection in experimental liver injury to the rat by carbon tetrachloride

1959 ◽  
Vol 72 (3) ◽  
pp. 384-389 ◽  
Author(s):  
D. K. Kasbekar ◽  
W. V. Lavate ◽  
D. V. Rege ◽  
A. Sreenivasan
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Vitamin B12 ◽  
Experimental Liver

Protective effects of vitamin b12 on acute experimental liver injury

1967 ◽  
Vol 2 (3) ◽  
pp. 231-232
Author(s):  
S. Inui ◽  
I. Aoyama ◽  
K. Oida ◽  
T. Kanie ◽  
K. Setta ◽  
...  
Keyword(s):  
Liver Injury ◽  
Vitamin B12 ◽  
Protective Effects ◽  
Experimental Liver

scholarly journals Antioxidant and Hepatoprotective Effect of Swertiamarin on Carbon Tetrachloride-Induced Hepatotoxicity via the Nrf2/HO-1 Pathway

2017 ◽  
Vol 41 (6) ◽  
pp. 2242-2254 ◽  
Author(s):  
Tao Wu ◽  
Jingjing Li ◽  
Yong Li ◽  
Hongping Song
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Detoxification Enzymes ◽  
Efflux Transporters ◽  
Protective Effects ◽  
Sprague Dawley ◽  
Bioactive Component ◽  
Antioxidase Activity ◽  
Oxide Synthase ◽  
Experimental Liver

Background/Aims: Swertiamarin (STM), the main bioactive component in Swertia mussotii Franch (Gentianaceae), has been shown to exert hepatoprotective effects on experimental liver injury. However, the effects and exact mechanisms of STM on carbon tetrachloride (CCl4) causing hepatotoxicity are still unknown. This study investigated the potential protective effects and mechanisms of STM on CCl4-induced liver injury in rats. Methods: Adult male Sprague-Dawley (SD) rats were exposed to CCl4 with or without STM co-administration for consecutive eight weeks. Results: STM significantly ameliorated CCl4-induced increase in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels and histopathological changes in the liver. Hepatic oxidative stress was repressed by STM, as evidenced by the decrease in malondialdehyde (MDA), with concomitant increase in antioxidase activity (e.g. superoxide dismutase (SOD); glutathione peroxidase (GPx)), glutathione (GSH) level. STM also obviously attenuated inflammatory response in CCl4-lesioned livers as evidenced by the decrease in inflammatory cytokines/ chemokines (e.g. inducible nitric oxide synthase (iNOS), interleukin-1β (IL-1β)). Additionally, STM significantly induced the expression of CYPs, efflux transporters and PDZK1 as compared with the CCl4 group. Moreover, co-administration of STM with CCl4 remarkably up-regulated the expression of Nrf2, HO-1 and NQO1 compared with the CCl4 group. Conclusions: The present study demonstrates that STM exerts a protective effect against CCl4-induced liver injury and inflammation with its antioxidant effects and induction of hepatic detoxification enzymes and efflux transporters expression, at least in part, via the Nrf2/HO-1 pathway in rats.

The pro‐fibrotic role of dipeptidyl peptidase 4 in carbon tetrachloride‐induced experimental liver injury

2016 ◽  
Vol 95 (5) ◽  
pp. 443-453 ◽  
Author(s):  
Xin M Wang ◽  
Lauren E Holz ◽  
Sumaiya Chowdhury ◽  
Shaun P Cordoba ◽  
Kathryn A Evans ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase 4 ◽  
Experimental Liver

scholarly journals Protective Action of Vitamin B12 in Experimental Liver Injury

Nature ◽  
1956 ◽  
Vol 178 (4540) ◽  
pp. 989-989
Author(s):  
D. K. KASBEKAR ◽  
D. V. REGE ◽  
A. SREENIVASAN
Keyword(s):  
Liver Injury ◽  
Vitamin B12 ◽  
Protective Action ◽  
Experimental Liver

Ameliorative Effect of Traditional Chinese Medicine Prescriptions on α-Naphthylisothiocyanate and Carbon-tetrachloride Induced Toxicity in Rats

1997 ◽  
Vol 25 (02) ◽  
pp. 185-196 ◽  
Author(s):  
Chin-Chuan Tsai ◽  
Shung-Te Kao ◽  
Chao-Tien Hsu ◽  
Chun-Ching Lin ◽  
Jim-Shoung Lai ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Carbon Tetrachloride ◽  
Traditional Chinese Medicine ◽  
Liver Injury ◽  
Serum Total Bilirubin ◽  
Glutamate Pyruvate Transaminase ◽  
Ameliorative Effect ◽  
Glutamate Pyruvate ◽  
Experimental Liver ◽  
Elevated Lipid

Syh-Mo-Yin (SMY), Guizhi-Fuling-Wan (GFW), Shieh-Qing-Wan (SQW) and Syh-Nih-San (SNS) are prescriptions of Traditional Chinese Medicine (TCM) for liver disease. The effects of these four prescriptions against experimental liver injury induced by α-Naphthylisothiocyanate (ANIT) and carbon tetrachloride ( CCl 4) were studied. Rats treated with ANIT (100 mg/kg) exhibited elevations of serum total bilirubin (TBI), alkaline phosphatase (ALP), glutamate-oxalatetransaminase (sGOT) and glutamate-pyruvate-transaminase (sGPT) as well as cholestasis and parenchymanecrosis. In rats receiving SMY, SQW and SNS treatment after ANIT challenged, the biochemical and morphological parameters of liver injury were significantly reduce. Elevated lipid peroxidation (LPO) level in liver tissue, associated with an increase in serum GOT and GPT level, was observed in CCl 4-treated rats. Treatment with these four prescriptions on CCl 4-induced liver injury rats showed a remarkable hepatoprotective effect. A significant decrease in peroxidative level suggested that these prescriptions have anti free radical properties.

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