Protective effects of vitamin b12 on acute experimental liver injury

1967 ◽  
Vol 2 (3) ◽  
pp. 231-232
Author(s):  
S. Inui ◽  
I. Aoyama ◽  
K. Oida ◽  
T. Kanie ◽  
K. Setta ◽  
...  
Keyword(s):  
Liver Injury ◽  
Vitamin B12 ◽  
Protective Effects ◽  
Experimental Liver

scholarly journals A study of vitamin B12 protection in experimental liver injury to the rat by carbon tetrachloride

1959 ◽  
Vol 72 (3) ◽  
pp. 384-389 ◽  
Author(s):  
D. K. Kasbekar ◽  
W. V. Lavate ◽  
D. V. Rege ◽  
A. Sreenivasan
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Vitamin B12 ◽  
Experimental Liver

scholarly journals Antioxidant and Hepatoprotective Effect of Swertiamarin on Carbon Tetrachloride-Induced Hepatotoxicity via the Nrf2/HO-1 Pathway

2017 ◽  
Vol 41 (6) ◽  
pp. 2242-2254 ◽  
Author(s):  
Tao Wu ◽  
Jingjing Li ◽  
Yong Li ◽  
Hongping Song
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Detoxification Enzymes ◽  
Efflux Transporters ◽  
Protective Effects ◽  
Sprague Dawley ◽  
Bioactive Component ◽  
Antioxidase Activity ◽  
Oxide Synthase ◽  
Experimental Liver

Background/Aims: Swertiamarin (STM), the main bioactive component in Swertia mussotii Franch (Gentianaceae), has been shown to exert hepatoprotective effects on experimental liver injury. However, the effects and exact mechanisms of STM on carbon tetrachloride (CCl4) causing hepatotoxicity are still unknown. This study investigated the potential protective effects and mechanisms of STM on CCl4-induced liver injury in rats. Methods: Adult male Sprague-Dawley (SD) rats were exposed to CCl4 with or without STM co-administration for consecutive eight weeks. Results: STM significantly ameliorated CCl4-induced increase in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels and histopathological changes in the liver. Hepatic oxidative stress was repressed by STM, as evidenced by the decrease in malondialdehyde (MDA), with concomitant increase in antioxidase activity (e.g. superoxide dismutase (SOD); glutathione peroxidase (GPx)), glutathione (GSH) level. STM also obviously attenuated inflammatory response in CCl4-lesioned livers as evidenced by the decrease in inflammatory cytokines/ chemokines (e.g. inducible nitric oxide synthase (iNOS), interleukin-1β (IL-1β)). Additionally, STM significantly induced the expression of CYPs, efflux transporters and PDZK1 as compared with the CCl4 group. Moreover, co-administration of STM with CCl4 remarkably up-regulated the expression of Nrf2, HO-1 and NQO1 compared with the CCl4 group. Conclusions: The present study demonstrates that STM exerts a protective effect against CCl4-induced liver injury and inflammation with its antioxidant effects and induction of hepatic detoxification enzymes and efflux transporters expression, at least in part, via the Nrf2/HO-1 pathway in rats.

scholarly journals Protective Action of Vitamin B12 in Experimental Liver Injury

Nature ◽  
1956 ◽  
Vol 178 (4540) ◽  
pp. 989-989
Author(s):  
D. K. KASBEKAR ◽  
D. V. REGE ◽  
A. SREENIVASAN
Keyword(s):  
Liver Injury ◽  
Vitamin B12 ◽  
Protective Action ◽  
Experimental Liver

scholarly journals Protective effects of Y-8845 against experimental liver injury

1983 ◽  
Vol 33 ◽  
pp. 115
Author(s):  
Noriyoshi Izumi ◽  
Toshihiro Kobayakawa ◽  
Hiroshi Yasuda
Keyword(s):  
Liver Injury ◽  
Protective Effects ◽  
Experimental Liver

scholarly journals Protective effects of Y-8845 against experimental liver injury

1984 ◽  
Vol 36 ◽  
pp. 364
Author(s):  
Shinichi Hatta ◽  
Atsushi Miyamoto ◽  
Yuko Suzuki ◽  
Haruo Takemura ◽  
Hideyo Ohshika ◽  
...  
Keyword(s):  
Liver Injury ◽  
Protective Effects ◽  
Experimental Liver

Effect of Dextran Sulfate on Experimental Liver Injury

Kanzo ◽  
1974 ◽  
Vol 15 (8) ◽  
pp. 463-471
Author(s):  
Setsuro FUJII ◽  
Hiromichi OKUDA
Keyword(s):  
Liver Injury ◽  
Dextran Sulfate ◽  
Experimental Liver

Protective effects of fucoidan against ethanol-induced liver injury through maintaining mitochondria function and mitophagy balance in rats.

2021 ◽  
Author(s):  
Huichao Zhao ◽  
Shuang Liu ◽  
Hui Zhao ◽  
Meilan Xue ◽  
Huaqi Zhang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Injury ◽  
Alcoholic Liver Disease ◽  
Therapeutic Strategy ◽  
Hepatic Lesion ◽  
Protective Effects ◽  
Regulatory Effects

For alcoholic liver disease (ALD), mitophagy was reported as a promising therapeutic strategy to alleviate the hepatic lesion elicited by ethanol. This study was to investigate the regulatory effects of...

scholarly journals Lemon Balm and Dandelion Leaf Extracts Synergistically Protect against Carbon Tetrachloride-Induced Acute Liver Injury in Mice

2021 ◽  
Vol 11 (1) ◽  
pp. 390
Author(s):  
Beom-Rak Choi ◽  
Il-Je Cho ◽  
Su-Jin Jung ◽  
Jae-Kwang Kim ◽  
Dae-Geon Lee ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Antioxidant Activities ◽  
Body Weight Gain ◽  
Histopathological Analysis ◽  
Related Factor ◽  
Mrna Levels ◽  
Protective Effects ◽  
Lemon Balm

Lemon balm and dandelion are commonly used medicinal herbs exhibiting numerous pharmacological activities that are beneficial for human health. In this study, we explored the protective effects of a 2:1 (w/w) mixture of lemon balm and dandelion extracts (MLD) on carbon tetrachloride (CCl4)-induced acute liver injury in mice. CCl4 (0.5 mL/kg; i.p.) injection inhibited body weight gain and increased relative liver weight. Pre-administration of MLD (50–200 mg/kg) for 7 days prevented these CCl4-mediated changes. In addition, histopathological analysis revealed that MLD synergistically alleviated CCl4-mediated hepatocyte degeneration and infiltration of inflammatory cells. MLD decreased serum aspartate aminotransferase and alanine transferase activities and reduced the number of liver cells that stained positive for cleaved caspase-3 and cleaved poly(ADP-ribose) polymerase, suggesting that MLD protects against CCl4-induced hepatic damage via the inhibition of apoptosis. Moreover, MLD attenuated CCl4-mediated lipid peroxidation and protein nitrosylation by restoring impaired hepatic nuclear factor erythroid 2-related factor 2 mRNA levels and its dependent antioxidant activities. Furthermore, MLD synergistically decreased mRNA and protein levels of tumor necrosis factor-α, interleukin-1β, and interleukin-6 in the liver. Together, these results suggest that MLD has potential for preventing acute liver injury by inhibiting apoptosis, oxidative stress, and inflammation.

scholarly journals F-Antigen: Nature Liver Specificity, and Release in Experimental Liver Injury

1976 ◽  
Vol 71 (1) ◽  
pp. 118-122 ◽  
Author(s):  
Yasuyuki Arakawa ◽  
David M. Bull ◽  
Chester F. Schott ◽  
Charles S. Davidson
Keyword(s):  
Liver Injury ◽  
Experimental Liver
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