scholarly journals Protective effects of total glucosides of paeony and the underlying mechanisms in carbon tetrachloride-induced experimental liver injury

2011 ◽  
Vol 4 ◽  
pp. 604-612 ◽  
Author(s):  
Ying Qin ◽  
Ya-ping Tian
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effects ◽  
Total Glucosides Of Paeony ◽  
Underlying Mechanisms ◽  
Experimental Liver

scholarly journals Antioxidant and Hepatoprotective Effect of Swertiamarin on Carbon Tetrachloride-Induced Hepatotoxicity via the Nrf2/HO-1 Pathway

2017 ◽  
Vol 41 (6) ◽  
pp. 2242-2254 ◽  
Author(s):  
Tao Wu ◽  
Jingjing Li ◽  
Yong Li ◽  
Hongping Song
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Detoxification Enzymes ◽  
Efflux Transporters ◽  
Protective Effects ◽  
Sprague Dawley ◽  
Bioactive Component ◽  
Antioxidase Activity ◽  
Oxide Synthase ◽  
Experimental Liver

Background/Aims: Swertiamarin (STM), the main bioactive component in Swertia mussotii Franch (Gentianaceae), has been shown to exert hepatoprotective effects on experimental liver injury. However, the effects and exact mechanisms of STM on carbon tetrachloride (CCl4) causing hepatotoxicity are still unknown. This study investigated the potential protective effects and mechanisms of STM on CCl4-induced liver injury in rats. Methods: Adult male Sprague-Dawley (SD) rats were exposed to CCl4 with or without STM co-administration for consecutive eight weeks. Results: STM significantly ameliorated CCl4-induced increase in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels and histopathological changes in the liver. Hepatic oxidative stress was repressed by STM, as evidenced by the decrease in malondialdehyde (MDA), with concomitant increase in antioxidase activity (e.g. superoxide dismutase (SOD); glutathione peroxidase (GPx)), glutathione (GSH) level. STM also obviously attenuated inflammatory response in CCl4-lesioned livers as evidenced by the decrease in inflammatory cytokines/ chemokines (e.g. inducible nitric oxide synthase (iNOS), interleukin-1β (IL-1β)). Additionally, STM significantly induced the expression of CYPs, efflux transporters and PDZK1 as compared with the CCl4 group. Moreover, co-administration of STM with CCl4 remarkably up-regulated the expression of Nrf2, HO-1 and NQO1 compared with the CCl4 group. Conclusions: The present study demonstrates that STM exerts a protective effect against CCl4-induced liver injury and inflammation with its antioxidant effects and induction of hepatic detoxification enzymes and efflux transporters expression, at least in part, via the Nrf2/HO-1 pathway in rats.

scholarly journals Lemon Balm and Dandelion Leaf Extracts Synergistically Protect against Carbon Tetrachloride-Induced Acute Liver Injury in Mice

2021 ◽  
Vol 11 (1) ◽  
pp. 390
Author(s):  
Beom-Rak Choi ◽  
Il-Je Cho ◽  
Su-Jin Jung ◽  
Jae-Kwang Kim ◽  
Dae-Geon Lee ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Antioxidant Activities ◽  
Body Weight Gain ◽  
Histopathological Analysis ◽  
Related Factor ◽  
Mrna Levels ◽  
Protective Effects ◽  
Lemon Balm

Lemon balm and dandelion are commonly used medicinal herbs exhibiting numerous pharmacological activities that are beneficial for human health. In this study, we explored the protective effects of a 2:1 (w/w) mixture of lemon balm and dandelion extracts (MLD) on carbon tetrachloride (CCl4)-induced acute liver injury in mice. CCl4 (0.5 mL/kg; i.p.) injection inhibited body weight gain and increased relative liver weight. Pre-administration of MLD (50–200 mg/kg) for 7 days prevented these CCl4-mediated changes. In addition, histopathological analysis revealed that MLD synergistically alleviated CCl4-mediated hepatocyte degeneration and infiltration of inflammatory cells. MLD decreased serum aspartate aminotransferase and alanine transferase activities and reduced the number of liver cells that stained positive for cleaved caspase-3 and cleaved poly(ADP-ribose) polymerase, suggesting that MLD protects against CCl4-induced hepatic damage via the inhibition of apoptosis. Moreover, MLD attenuated CCl4-mediated lipid peroxidation and protein nitrosylation by restoring impaired hepatic nuclear factor erythroid 2-related factor 2 mRNA levels and its dependent antioxidant activities. Furthermore, MLD synergistically decreased mRNA and protein levels of tumor necrosis factor-α, interleukin-1β, and interleukin-6 in the liver. Together, these results suggest that MLD has potential for preventing acute liver injury by inhibiting apoptosis, oxidative stress, and inflammation.

Protective effects of theasinensin A against carbon tetrachloride-induced liver injury in mice

2017 ◽  
Vol 8 (9) ◽  
pp. 3276-3287 ◽  
Author(s):  
Wei-Lun Hung ◽  
Guliang Yang ◽  
Yu-Chuan Wang ◽  
Yi-Shiou Chiou ◽  
Yen-Chen Tung ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effects

TSA markedly reduced the CCl4-induced liver injury in mice.

Protective effects of BML-111, a lipoxin A4receptor agonist, on carbon tetrachloride-induced liver injury in mice

2007 ◽  
Vol 37 (11) ◽  
pp. 948-956 ◽  
Author(s):  
Li Zhang ◽  
Jingyuan Wan ◽  
Hongzhong Li ◽  
Ping Wu ◽  
Shengwei Jin ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effects

Protective effects of salecan against carbon tetrachloride-induced acute liver injury in mice

2011 ◽  
Vol 32 (10) ◽  
pp. 796-803 ◽  
Author(s):  
Peng Chen ◽  
Zhongqiu Wang ◽  
Liyan Zeng ◽  
Shiming Wang ◽  
Wei Dong ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Protective Effects

scholarly journals Combined Water Extracts from Oxidation-Treated Leaves and Branches of Hovenia dulcis Has Anti-Hangover and Liver Protective Effects in Binge Alcohol Intake of Male Mice

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4404
Author(s):  
Jihyun Je ◽  
Miyoung Song ◽  
Ji Hyeong Baek ◽  
Jae Soon Kang ◽  
Hye Jin Chung ◽  
...  
Keyword(s):  
Liver Injury ◽  
Traditional Medicine ◽  
Alcohol Intake ◽  
Protective Effects ◽  
Male Mice ◽  
Protective Properties ◽  
Water Extracts ◽  
Underlying Mechanisms ◽  
Dried Extract ◽  
Hovenia Dulcis

Hovenia dulcis, known as the oriental raisin tree, is used for food supplements and traditional medicine for the liver after alcohol-related symptoms. However, little information exists about the use of its leaves and branches. In this study, we established a method to use the leaves and branches to develop anti-hangover treatment and elucidated the underlying mechanisms. Oxidation-treated leaves (OL) exhibited high antioxidant content comparable to that of the peduncles and showed an anti-hangover effect in male mice. The branch extract (BE) was enriched in the flavonoid catechin, approximately five times more than OL extract. The mixture of OL and BE (OLB) was formulated in a 2:1 ratio with frozen-dried extract weight and was tested for anti-hangover effects and protective properties against binge alcohol-induced liver injury. OLB showed better anti-hangover effect than OL. In addition to this anti-hangover effect, OLB protected the liver from oxidative/nitrosative damage induced by binge alcohol intake.

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