A convenient one-pot synthesis of cystine-containing peptides from protected peptidyl resins using the trimethylsilyl chloride–dimethyl sulfoxide–trifluoroacetic acid system

1996 ◽  
pp. 1911-1912 ◽  
Author(s):  
Hirokazu Tamamura ◽  
Tsunehito Ishihara ◽  
Akira Otaka ◽  
Takaki Koide ◽  
Kengo Miyoshi ◽  
...  
Keyword(s):  
Dimethyl Sulfoxide ◽  
Trifluoroacetic Acid ◽  
Acid System ◽  
One Pot ◽  
One Pot Synthesis

Facile Approach to Geminal Heterodihalogenation. One-Pot Synthesis of α-Bromo-α-Chloro Ketones

Synlett ◽  
2020 ◽  
Vol 31 (14) ◽  
pp. 1430-1434
Author(s):  
Ming Bian ◽  
Jin-feng Zhou ◽  
Dong-min Tang
Keyword(s):  
Drug Discovery ◽  
Dimethyl Sulfoxide ◽  
Functional Groups ◽  
Methyl Ketones ◽  
One Pot ◽  
One Pot Synthesis ◽  
Operational Simplicity

An efficient and practical protocol for the geminal heterodihalogenation of methyl ketones by using readily available dimethyl sulfoxide and a combination of HCl and HBr is reported. Control experiments suggested that the acidity of the solution, as well as the oxidizing ability and nucleophilicity of the dimethyl sulfoxide might work cooperatively in ensuring the success of the tandem substitution. Its operational simplicity, easy accessibility, and mild oxidative conditions suggest that the present strategy might be useful for the assembly of bromochloromethyl functional groups in drug discovery.

scholarly journals One-Pot Synthesis ofN-[3-(4-Methylphenyl)-3-oxo-1-arylpropyl]ace-tamides Employing Trifluoroacetic Acid as an Efficient Catalyst

2013 ◽  
Vol 33 (5) ◽  
pp. 1047 ◽  
Author(s):  
Zhenghong Ren ◽  
Sheng Li ◽  
Xinghua Zhang ◽  
Li Fan ◽  
Guangming Zhou ◽  
...  
Keyword(s):  
Trifluoroacetic Acid ◽  
One Pot ◽  
Efficient Catalyst ◽  
One Pot Synthesis

Dimethyl Sulfoxide Involved One-Pot Synthesis of Quinoxaline Derivatives

2017 ◽  
Vol 82 (7) ◽  
pp. 3491-3499 ◽  
Author(s):  
Caixia Xie ◽  
Zeyuan Zhang ◽  
Danyang Li ◽  
Jian Gong ◽  
Xushuang Han ◽  
...  
Keyword(s):  
Dimethyl Sulfoxide ◽  
One Pot ◽  
One Pot Synthesis ◽  
Quinoxaline Derivatives
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