Convenient one-pot synthesis of cystine-containing peptides using the trimethylsilyl chloride–dimethyl sulfoxide/trifluoroacetic acid system and its application to the synthesis of bifunctional anti-HIV compounds 1

1998 ◽  
pp. 495-500 ◽  
Author(s):  
Hirokazu Tamamura ◽  
Tsunehito Ishihara ◽  
Hiromi Oyake ◽  
Makoto Imai ◽  
Akira Otaka ◽  
...  
Keyword(s):  
Dimethyl Sulfoxide ◽  
Trifluoroacetic Acid ◽  
Acid System ◽  
One Pot ◽  
One Pot Synthesis ◽  
Anti Hiv

Facile Approach to Geminal Heterodihalogenation. One-Pot Synthesis of α-Bromo-α-Chloro Ketones

Synlett ◽  
2020 ◽  
Vol 31 (14) ◽  
pp. 1430-1434
Author(s):  
Ming Bian ◽  
Jin-feng Zhou ◽  
Dong-min Tang
Keyword(s):  
Drug Discovery ◽  
Dimethyl Sulfoxide ◽  
Functional Groups ◽  
Methyl Ketones ◽  
One Pot ◽  
One Pot Synthesis ◽  
Operational Simplicity

An efficient and practical protocol for the geminal heterodihalogenation of methyl ketones by using readily available dimethyl sulfoxide and a combination of HCl and HBr is reported. Control experiments suggested that the acidity of the solution, as well as the oxidizing ability and nucleophilicity of the dimethyl sulfoxide might work cooperatively in ensuring the success of the tandem substitution. Its operational simplicity, easy accessibility, and mild oxidative conditions suggest that the present strategy might be useful for the assembly of bromochloromethyl functional groups in drug discovery.

One-Pot Synthesis of Aryl Phosphoramidate Derivatives of AZT/d4T as Anti-HIV Prodrugs

Synlett ◽  
2005 ◽  
pp. 2537-2539 ◽  
Author(s):  
Hua Fu ◽  
Peng Jiang ◽  
Xin Guo ◽  
Yuyang Jiang ◽  
Yufen Zhao
Keyword(s):  
One Pot ◽  
One Pot Synthesis ◽  
Derivatives Of ◽  
Anti Hiv

Efficient One-Pot Synthesis of anti-HIV and Antitumor Compounds: Harman and Substituted Harmans.

ChemInform ◽  
2003 ◽  
Vol 34 (38) ◽  
Author(s):  
Radhika S. Kusurkar ◽  
Shailesh K. Goswami ◽  
Sandhya M. Vyas
Keyword(s):  
One Pot ◽  
One Pot Synthesis ◽  
Antitumor Compounds ◽  
Anti Hiv

Efficient One-Pot Synthesis of anti-HIV and Antitumor β-Carbolines.

ChemInform ◽  
2004 ◽  
Vol 35 (39) ◽  
Author(s):  
Radhika S. Kusurkar ◽  
Shailesh K. Goswami
Keyword(s):  
One Pot ◽  
One Pot Synthesis ◽  
Anti Hiv

Reactivity-Based One-Pot Synthesis of Oligomannoses: Defining Antigens Recognized by 2G12, a Broadly Neutralizing Anti-HIV-1 Antibody

2004 ◽  
Vol 43 (8) ◽  
pp. 1000-1003 ◽  
Author(s):  
Hing-Ken Lee ◽  
Christopher N. Scanlan ◽  
Cheng-Yuan Huang ◽  
Aileen Y. Chang ◽  
Daniel A. Calarese ◽  
...  
Keyword(s):  
One Pot ◽  
One Pot Synthesis ◽  
Anti Hiv ◽  
Hiv 1

Reactivity-Based One-Pot Synthesis of Oligomannoses: Defining Antigens Recognized by 2G12, a Broadly Neutralizing Anti-HIV-1 Antibody

2004 ◽  
Vol 116 (8) ◽  
pp. 1018-1021 ◽  
Author(s):  
Hing-Ken Lee ◽  
Christopher N. Scanlan ◽  
Cheng-Yuan Huang ◽  
Aileen Y. Chang ◽  
Daniel A. Calarese ◽  
...  
Keyword(s):  
One Pot ◽  
One Pot Synthesis ◽  
Anti Hiv ◽  
Hiv 1
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