Highly sensitive all-polymer photodetectors with ultraviolet-visible to near-infrared photo-detection and its application as optical switch

Author(s):  
Zijin Zhao ◽  
Baiqiao Liu ◽  
Chunyu Xu ◽  
Ming Liu ◽  
Kaixuan Yang ◽  
...  

All-polymer photodetectors with photomultiplication are fabricated with PMBBDT and N2200 as photoactive layers, exhibiting external quantum efficiency of 20700% under 4 V. Signal-to-noise ratio, linear dynamic range and specific detectivity...

Author(s):  
Mahboubeh Berizi ◽  
Jalal Babaie ◽  
Pezhman Fard-Esfahani ◽  
Marjan Enshaeieh ◽  
Rahmah Noordin ◽  
...  

Background: Toxoplasmosis is a worldwide-distributed infection that can cause serious diseases, mainly in congenitally infected and immunodeficient individuals. PCR assays play an indispensable role in the detection of Toxoplasma gondii in different biological samples. Methods: This study was conducted in the Parasitology Department at Pasteur Institute of Iran (Tehran) during 2016-2018. We designed a highly sensitive quantitative real-time PCR (RT-qPCR) targeted REP-529, a noncoding repetitive DNA. We cloned the amplicon in a plasmid (pTZREP-529) and used it to generate the standard curve. The Toxoplasma RT-qPCR characteristics, i.e., detection limit, specificity, linear dynamic range, linearity, intra-, and inter-assay precisions, were determined. The detection limit of the assay was one plasmid copy number (PCN) per reaction (about 0.004 T. gondii genome), and the linear dynamic range was equal to 6 logs (1× 101 to 1× 107 PCN per reaction). Results: The assay showed no signal when genomic DNA of Plasmodium falciparum, Leishmania major, and Trichomonas vaginallis were used. The standard curve was drawn using dilutions of pTZREP-529 plasmid spiked with genomic DNA from a mouse brain, and test characteristics were shown unaffected. Applying the Toxoplasma RT-qPCR, we showed brain cysts were significantly decreased in mice vaccinated with GRA2 antigen of Toxoplasma formulated in Monophosphoryl Lipid A (MPL) adjuvant. Conclusion: We have developed a quantitative, specific, and highly sensitive PCR for detecting T. gondii in biological samples.


Small ◽  
2017 ◽  
Vol 13 (24) ◽  
pp. 1603260 ◽  
Author(s):  
Riming Nie ◽  
Xianyu Deng ◽  
Lei Feng ◽  
Guiguang Hu ◽  
Yangyang Wang ◽  
...  

1994 ◽  
Vol 48 (9) ◽  
pp. 1102-1110 ◽  
Author(s):  
John W. Judge ◽  
Victoria L. McGuffin

The photovoltaic method for the detection of liquid-phase photoionization in the absence of an applied electric field is compared to the traditional photoconductive method. Each system is characterized by means of signal and signal-to-noise ratio measurements with respect to laser pulse energy, applied voltage, electrode separation distance, solute concentration, and solvent composition. Although both techniques exhibit similar detection limits (1 × 10−7 M) for solutes in polar solvents such as methanol and water, the photovoltaic technique has a more extensive linear dynamic range (103). Moreover, this technique allows detection of solutes in ionic solutions with comparable detectability and linearity.


2020 ◽  
Vol 2020 (7) ◽  
pp. 143-1-143-6 ◽  
Author(s):  
Yasuyuki Fujihara ◽  
Maasa Murata ◽  
Shota Nakayama ◽  
Rihito Kuroda ◽  
Shigetoshi Sugawa

This paper presents a prototype linear response single exposure CMOS image sensor with two-stage lateral overflow integration trench capacitors (LOFITreCs) exhibiting over 120dB dynamic range with 11.4Me- full well capacity (FWC) and maximum signal-to-noise ratio (SNR) of 70dB. The measured SNR at all switching points were over 35dB thanks to the proposed two-stage LOFITreCs.


1989 ◽  
Vol 43 (3) ◽  
pp. 422-425 ◽  
Author(s):  
Richard T. Madison ◽  
Mary K. Carroll ◽  
Gary M. Hieftje

A sample cell for observing the Shpol'skii effect at 77 K is described and analytically assessed. The cell employs fiber-optic light guides to transport excitation and emission radiation. The system is compact, inexpensive, and simple to construct from commercially available laboratory components, and it alleviates several problems inherent in conventional refrigerated-cell designs. Detection limits for anthracene, coronene, and pyrene obtained with the sample cell are 8.8 × 10−8 M, 8.4 × 10−7 M, and 3.5 × 10−7 M, respectively. The linear dynamic range for each compound is 2 to 3 orders of magnitude.


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