131I-labeled gold nanoframeworks for radiotherapy-combined second near-infrared photothermal therapy of cancer

2021 ◽  
Author(s):  
Danling Cheng ◽  
Jiali Gong ◽  
Peng Wang ◽  
Jingyi Zhu ◽  
Ningyue Yu ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Heat Generation ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Great Promise ◽  
Anticancer Efficacy

Photothermal therapy (PTT) has shown a great promise for cancer treatment via light-triggered heat generation, while the anticancer efficacy of sole PTT is often limited. In this study, we report...

scholarly journals Polypeptide-Based Gold Nanoshells for Photothermal Therapy

2016 ◽  
Vol 22 (1) ◽  
pp. 18-25 ◽  
Author(s):  
Kristine M. Mayle ◽  
Kathryn R. Dern ◽  
Vincent K. Wong ◽  
Shijun Sung ◽  
Ke Ding ◽  
...  
Keyword(s):  
Heat Generation ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Gold Nanoshells ◽  
Core Material ◽  
Infrared Light ◽  
Great Promise ◽  
Laser Exposure ◽  
Enhanced Absorption ◽  
Block Copolypeptide

Targeted killing of cancer cells by engineered nanoparticles holds great promise for noninvasive photothermal therapy applications. We present the design and generation of a novel class of gold nanoshells with cores composed of self-assembled block copolypeptide vesicles with photothermal properties. Specifically, poly(L-lysine)60- block-poly(L-leucine)20 (K60L20) block copolypeptide vesicles coated with a thin layer of gold demonstrate enhanced absorption of light due to surface plasmon resonance (SPR) in the near-infrared range. We show that the polypeptide-based K60L20 gold nanoshells have low toxicity in the absence of laser exposure, significant heat generation upon exposure to near-infrared light, and, as a result, localized cytotoxicity within the region of laser irradiation in vitro. To gain a better understanding of our gold nanoshells in the context of photothermal therapy, we developed a comprehensive mathematical model for heat transfer and experimentally validated this model by predicting the temperature as a function of time and position in our experimental setup. This model can be used to predict which parameters of our gold nanoshells can be manipulated to improve heat generation for tumor destruction. To our knowledge, our results represent the first ever use of block copolypeptide vesicles as the core material of gold nanoshells.

The Role of NIR Fluorescence in MDR Cancer Treatment: From Targeted Imaging to Phototherapy

2020 ◽  
Vol 27 (33) ◽  
pp. 5510-5529
Author(s):  
Zengtao Wang ◽  
Qingqing Meng ◽  
Shaoshun Li
Keyword(s):  
Cancer Treatment ◽  
Near Infrared ◽  
Combined Therapy ◽  
Efflux Pumps ◽  
Cross Resistance ◽  
Great Promise ◽  
Drug Efflux ◽  
Nir Dyes ◽  
Nir Imaging ◽  
Drug Efflux Pumps

Background: Multidrug Resistance (MDR) is defined as a cross-resistance of cancer cells to various chemotherapeutics and has been demonstrated to correlate with drug efflux pumps. Visualization of drug efflux pumps is useful to pre-select patients who may be insensitive to chemotherapy, thus preventing patients from unnecessary treatment. Near-Infrared (NIR) imaging is an attractive approach to monitoring MDR due to its low tissue autofluorescence and deep tissue penetration. Molecular NIR imaging of MDR cancers requires stable probes targeting biomarkers with high specificity and affinity. Objective: This article aims to provide a concise review of novel NIR probes and their applications in MDR cancer treatment. Results: Recently, extensive research has been performed to develop novel NIR probes and several strategies display great promise. These strategies include chemical conjugation between NIR dyes and ligands targeting MDR-associated biomarkers, native NIR dyes with inherent targeting ability, activatable NIR probes as well as NIR dyes loaded nanoparticles. Moreover, NIR probes have been widely employed for photothermal and photodynamic therapy in cancer treatment, which combine with other modalities to overcome MDR. With the rapid advancing of nanotechnology, various nanoparticles are incorporated with NIR dyes to provide multifunctional platforms for controlled drug delivery and combined therapy to combat MDR. The construction of these probes for MDR cancers targeted NIR imaging and phototherapy will be discussed. Multimodal nanoscale platform which integrates MDR monitoring and combined therapy will also be encompassed. Conclusion: We believe these NIR probes project a promising approach for diagnosis and therapy of MDR cancers, thus holding great potential to reach clinical settings in cancer treatment.

Cascade targeting tumor mitochondria with CuS nanoparticles for enhanced photothermal therapy in the second near-infrared window

2021 ◽  
Author(s):  
Haiyan Wu ◽  
Pengpeng Jia ◽  
Yu Zou ◽  
Jiang Jiang
Keyword(s):  
Treatment Outcome ◽  
Heat Generation ◽  
Side Effect ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Local Heat ◽  
Potential Side Effect ◽  
Improve Treatment ◽  
Improve Treatment Outcome ◽  
Local Heat Generation

Photothermal therapy, assisted by local heat generation using photothermal nanoparticles (NPs), is an emerging strategy to treat tumors noninvasively. To improve treatment outcome and to alleviate potential side effect on...

Highly stable near-infrared dye conjugated cerasomes for fluorescence imaging-guided synergistic chemo-photothermal therapy of colorectal cancer

2019 ◽  
Vol 7 (7) ◽  
pp. 2873-2888 ◽  
Author(s):  
Xu Zhang ◽  
Xiaolong Liang ◽  
Xiaotu Ma ◽  
Rui Hou ◽  
Xiaoda Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Release ◽  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
High Stability ◽  
Near Infrared ◽  
Great Promise ◽  
Near Infrared Dye

Dye-conjugated cerasome loaded with DOX exhibited high stability and controllable drug release, holding great promise in colorectal cancer photothermal chemotherapy.

scholarly journals Injectable and Temperature-Sensitive Titanium Carbide-Loaded Hydrogel System for Photothermal Therapy of Breast Cancer

2021 ◽  
Vol 9 ◽  
Author(s):  
Jun Yao ◽  
Chuanda Zhu ◽  
Tianjiao Peng ◽  
Qiang Ma ◽  
Shegan Gao
Keyword(s):  
Titanium Carbide ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Therapeutic Strategy ◽  
Near Infrared ◽  
Pluronic F127 ◽  
Temperature Sensitive ◽  
Hydrogel System

Recently, organic–inorganic hybrid materials have gained much attention as effective photothermal agents for cancer treatment. In this study, Pluronic F127 hydrogel-coated titanium carbide (Ti3C2) nanoparticles were utilized as an injectable photothermal agent. The advantages of these nanoparticles are their green synthesis and excellent photothermal efficiency. In this system, lasers were mainly used to irradiate Ti3C2 nanoparticles to produce a constant high temperature, which damaged cancer cells. The nanoparticles were found to be stable during storage at low temperatures for at least 2 weeks. The Ti3C2 nanoparticles exhibited a shuttle-shaped structure, and the hydrogels presented a loosely meshed structure. In addition, Ti3C2 nanoparticles did not affect the reversible temperature sensitivity of the gel, and the hydrogel did not affect the photothermal properties of Ti3C2 nanoparticles. The in vitro and in vivo results show that this hydrogel system can effectively inhibit tumor growth upon exposure to near-infrared irradiation with excellent biocompatibility and biosafety. The photothermal agent-embedded hydrogel is a promising photothermal therapeutic strategy for cancer treatment by enhancing the retention in vivo and elevating the local temperature in tumors.

Highly efficient near-infrared BODIPY phototherapeutic nanoparticles for cancer treatment

2020 ◽  
Vol 8 (24) ◽  
pp. 5305-5311
Author(s):  
Yuandong Zhang ◽  
Zhiyu Yang ◽  
Xiaohua Zheng ◽  
Li Chen ◽  
Zhigang Xie
Keyword(s):  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Highly Efficient

A highly efficient NIR BODIPY nano-photosensitizer constructed by multi-intersection effects provides beneficial guidance for photodynamic and photothermal therapy.

scholarly journals Near-Infrared Photothermal Therapy Cancer Treatment Assisted with Graphene-Based Materials

2020 ◽  
Vol 2 (2) ◽  
pp. 26
Keyword(s):  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Density Functional ◽  
Near Infrared ◽  
Density Functional Theory Calculation ◽  
Infrared Light ◽  
Light Sources ◽  
Near Infrared Light ◽  
New Material ◽  
Theory Calculation

Photothermal therapy is an emerging method of cancer treatment in which tumors are ablated by heating agents using near-infrared light (700–1000 nm). A semiconductor with a bandgap between 0.3–0.7 eV would, therefore, efficiently emit near-infrared light. The new “magic” material graphene has a bandgap of zero, which is advantageous with regard to designing a new material with a suitable bandgap for the emission of near-infrared light. In our investigations, using the first-principles density functional theory calculation method, we aimed to and successfully designed graphene-based materials with a direct bandgap of 0.68 eV. They have the potential to be optimal and efficient near-infrared light sources due to their narrow yet fitting bandgap. The present results open up a new avenue for the application of graphene-based materials to assist in photothermal therapy.

scholarly journals An On-Demand pH-Sensitive Nanocluster for Cancer Treatment by Combining Photothermal Therapy and Chemotherapy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 839 ◽  
Author(s):  
Taehoon Sim ◽  
Chaemin Lim ◽  
Ngoc Ha Hoang ◽  
Yuseon Shin ◽  
Jae Chang Kim ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Therapeutic Effect ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Ph Sensitive ◽  
Systemic Toxicity ◽  
Infrared Light ◽  
Nc System ◽  
On Demand ◽  
Ph Sensitive Polymer

Combination therapy is considered to be a promising strategy for improving the therapeutic efficiency of cancer treatment. In this study, an on-demand pH-sensitive nanocluster (NC) system was prepared by the encapsulation of gold nanorods (AuNR) and doxorubicin (DOX) by a pH-sensitive polymer, poly(aspartic acid-graft-imidazole)-PEG, to enhance the therapeutic effect of chemotherapy and photothermal therapy. At pH 6.5, the NC systems formed aggregated structures and released higher drug amounts while sustaining a stable nano-assembly, structured with less systemic toxicity at pH 7.4. The NC could also increase antitumor efficacy as a result of improved accumulation and release of DOX from the NC system at pHex and pHen with locally applied near-infrared light. Therefore, an NC system would be a potent strategy for on-demand combination treatment to target tumors with less systemic toxicity and an improved therapeutic effect.

scholarly journals Immunostimulatory photochemotherapeutic nanocapsule for enhanced colon cancer treatment

Nanophotonics ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Jie Liu ◽  
Fatemeh Movahedi ◽  
Bing Sun ◽  
Luyao Sun ◽  
Bing Zhang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Treatment ◽  
Near Infrared ◽  
Great Promise ◽  
Combination Strategy ◽  
Colon Tumors ◽  
Cancer Cell Death ◽  
Therapeutic Drugs ◽  
Great Progress ◽  
Primary Colon

Abstract Immunotherapy has made great progress in recent years while most cancer patients cannot benefit from it. Photochemotherapy combination strategy holds great promise for developing novel immunotherapy for the patients bearing immunosuppressive tumors such as colon cancer. In this research, a novel core/shell-structured polydopamine (PDA)-based nanoplatform is constructed to load two Food and Drug Administration (FDA)-approved cytotoxic drugs, i.e. immunostimulatory doxorubicin (Dox) and immunomodulatory curcumin (Cur) to achieve immunostimulatory photochemotherapy of primary colon tumors upon 808 nm near infrared (NIR) irradiation (1 W/cm2 for 5 min) and subsequent prevention of rechallenged distant colon tumors. The experimental data have shown that PDA-mediated photothermal therapy (PTT) synergized two therapeutic drugs in inducing colon cancer cell death and very efficiently inhibited the primary tumor growth (by ∼92%) at very low doses of therapeutics (0.25, 5, and 30 mg/kg of Dox, Cur, and PDA, respectively). More significantly, the combined photochemotherapy promoted strong adaptive antitumor immune responses and successfully prevented tumorigenesis in the setting of tumor rechallenge model. Our research has thus demonstrated the promising efficacy of this photochemotherapeutic nanoformulation for colon cancer treatment and provided a way to improve immunostimulatory effects of conventional chemotherapeutic drugs.

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