Highly stable near-infrared dye conjugated cerasomes for fluorescence imaging-guided synergistic chemo-photothermal therapy of colorectal cancer

2019 ◽  
Vol 7 (7) ◽  
pp. 2873-2888 ◽  
Author(s):  
Xu Zhang ◽  
Xiaolong Liang ◽  
Xiaotu Ma ◽  
Rui Hou ◽  
Xiaoda Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Release ◽  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
High Stability ◽  
Near Infrared ◽  
Great Promise ◽  
Near Infrared Dye

Dye-conjugated cerasome loaded with DOX exhibited high stability and controllable drug release, holding great promise in colorectal cancer photothermal chemotherapy.

EGFR-targeted micelles containing near-infrared dye for enhanced photothermal therapy in colorectal cancer

2017 ◽  
Vol 258 ◽  
pp. 196-207 ◽  
Author(s):  
Ying-Hsia Shih ◽  
Tsai-Yueh Luo ◽  
Ping-Fang Chiang ◽  
Cheng-Jung Yao ◽  
Wuu-Jyh Lin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Near Infrared Dye

Stable Twisted Conformation Aza-BODIPY NIR-II Fluorescent Nanoparticles with Ultra-large Stokes Shift for Imaging-Guided Phototherapy

2022 ◽  
Author(s):  
Youliang Tian ◽  
Huiting Zhou ◽  
Quan Cheng ◽  
Huiping Dang ◽  
Hongyun Qian ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Stokes Shift ◽  
Great Promise ◽  
Deep Penetration ◽  
Fluorescent Nanoparticles ◽  
Spatiotemporal Resolution ◽  
Large Stokes Shift

Fluorescence imaging in the second near-infrared window (NIR-II, 1000–1700 nm) holds great promise for in vivo imaging and imaging-guided phototherapy with deep penetration and high spatiotemporal resolution. It is very...

Two-photon-excited near-infrared emissive carbon dots as multifunctional agents for fluorescence imaging and photothermal therapy

Nano Research ◽  
2017 ◽  
Vol 10 (9) ◽  
pp. 3113-3123 ◽  
Author(s):  
Minhuan Lan ◽  
Shaojing Zhao ◽  
Zhenyu Zhang ◽  
Li Yan ◽  
Liang Guo ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Carbon Dots ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Two Photon ◽  
Multifunctional Agents

scholarly journals Polypeptide-Based Gold Nanoshells for Photothermal Therapy

2016 ◽  
Vol 22 (1) ◽  
pp. 18-25 ◽  
Author(s):  
Kristine M. Mayle ◽  
Kathryn R. Dern ◽  
Vincent K. Wong ◽  
Shijun Sung ◽  
Ke Ding ◽  
...  
Keyword(s):  
Heat Generation ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Gold Nanoshells ◽  
Core Material ◽  
Infrared Light ◽  
Great Promise ◽  
Laser Exposure ◽  
Enhanced Absorption ◽  
Block Copolypeptide

Targeted killing of cancer cells by engineered nanoparticles holds great promise for noninvasive photothermal therapy applications. We present the design and generation of a novel class of gold nanoshells with cores composed of self-assembled block copolypeptide vesicles with photothermal properties. Specifically, poly(L-lysine)60- block-poly(L-leucine)20 (K60L20) block copolypeptide vesicles coated with a thin layer of gold demonstrate enhanced absorption of light due to surface plasmon resonance (SPR) in the near-infrared range. We show that the polypeptide-based K60L20 gold nanoshells have low toxicity in the absence of laser exposure, significant heat generation upon exposure to near-infrared light, and, as a result, localized cytotoxicity within the region of laser irradiation in vitro. To gain a better understanding of our gold nanoshells in the context of photothermal therapy, we developed a comprehensive mathematical model for heat transfer and experimentally validated this model by predicting the temperature as a function of time and position in our experimental setup. This model can be used to predict which parameters of our gold nanoshells can be manipulated to improve heat generation for tumor destruction. To our knowledge, our results represent the first ever use of block copolypeptide vesicles as the core material of gold nanoshells.

Theranostic Nanomedicine Carrying L‐Menthol and Near‐Infrared Dye for Multimodal Imaging‐Guided Photothermal Therapy of Cancer

2019 ◽  
Vol 8 (16) ◽  
pp. 1900409 ◽  
Author(s):  
Chunyang Zhang ◽  
Jie Liu ◽  
Huanling Guo ◽  
Wei Wang ◽  
Ming Xu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Multimodal Imaging ◽  
Near Infrared ◽  
Near Infrared Dye

Clinical use of organic near-infrared fluorescent contrast agents in image-guided oncologic procedures and its potential in veterinary oncology

2018 ◽  
Vol 183 (11) ◽  
pp. 354-354 ◽  
Author(s):  
Sophie Favril ◽  
Eline Abma ◽  
Francesco Blasi ◽  
Emmelie Stock ◽  
Nausikaa Devriendt ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Fluorescent Probes ◽  
Near Infrared ◽  
Sentinel Lymph Node Mapping ◽  
Cost Effective ◽  
Surgical Oncology ◽  
Great Promise ◽  
Lymph Node Mapping ◽  
Nir Light ◽  
Nir Fluorescence

One of the major challenges in surgical oncology is the intraoperative discrimination of tumoural versus healthy tissue. Until today, surgeons rely on visual inspection and palpation to define the tumoural margins during surgery and, unfortunately, for various cancer types, the local recurrence rate thus remains unacceptably high. Near-infrared (NIR) fluorescence imaging is an optical imaging technique that can provide real-time preoperative and intraoperative information after administration of a fluorescent probe that emits NIR light once exposed to a NIR light source. This technique is safe, cost-effective and technically easy. Several NIR fluorescent probes are currently studied for their ability to highlight neoplastic cells. In addition, NIR fluorescence imaging holds great promise for sentinel lymph node mapping. The aim of this manuscript is to provide a literature review of the current organic NIR fluorescent probes tested in the light of human oncology and to introduce fluorescence imaging as a valuable asset in veterinary oncology.

Oral Nanostructured Lipid Carriers Loaded with Near-Infrared Dye for Image-Guided Photothermal Therapy

2016 ◽  
Vol 8 (38) ◽  
pp. 25087-25095 ◽  
Author(s):  
Gang Chen ◽  
Kaikai Wang ◽  
Yiwen Zhou ◽  
Ling Ding ◽  
Aftab Ullah ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Nanostructured Lipid Carriers ◽  
Image Guided ◽  
Near Infrared Dye
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