Highly efficient near-infrared BODIPY phototherapeutic nanoparticles for cancer treatment

2020 ◽  
Vol 8 (24) ◽  
pp. 5305-5311
Author(s):  
Yuandong Zhang ◽  
Zhiyu Yang ◽  
Xiaohua Zheng ◽  
Li Chen ◽  
Zhigang Xie
Keyword(s):  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Highly Efficient

A highly efficient NIR BODIPY nano-photosensitizer constructed by multi-intersection effects provides beneficial guidance for photodynamic and photothermal therapy.

scholarly journals Carambola-like Bi2Te3 superstructures with enhanced photoabsorption for highly efficient photothermal therapy in the sencond biowindow

2021 ◽  
Author(s):  
Yinghui Wang ◽  
Ying Zhao ◽  
Yang Liu ◽  
Qishun Wang ◽  
Jianhua Liu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Highly Efficient ◽  
Penetration Ability ◽  
Maximum Permissible Exposure

Photothermal therapy (PTT) stimulated by the lights in the second near-infrared (NIR-II) biowindow shows great superiorities in penetration ability of tissue and maximum permissible exposure (MPE). Exploring new photothermal agents...

scholarly journals Injectable and Temperature-Sensitive Titanium Carbide-Loaded Hydrogel System for Photothermal Therapy of Breast Cancer

2021 ◽  
Vol 9 ◽  
Author(s):  
Jun Yao ◽  
Chuanda Zhu ◽  
Tianjiao Peng ◽  
Qiang Ma ◽  
Shegan Gao
Keyword(s):  
Titanium Carbide ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Therapeutic Strategy ◽  
Near Infrared ◽  
Pluronic F127 ◽  
Temperature Sensitive ◽  
Hydrogel System

Recently, organic–inorganic hybrid materials have gained much attention as effective photothermal agents for cancer treatment. In this study, Pluronic F127 hydrogel-coated titanium carbide (Ti3C2) nanoparticles were utilized as an injectable photothermal agent. The advantages of these nanoparticles are their green synthesis and excellent photothermal efficiency. In this system, lasers were mainly used to irradiate Ti3C2 nanoparticles to produce a constant high temperature, which damaged cancer cells. The nanoparticles were found to be stable during storage at low temperatures for at least 2 weeks. The Ti3C2 nanoparticles exhibited a shuttle-shaped structure, and the hydrogels presented a loosely meshed structure. In addition, Ti3C2 nanoparticles did not affect the reversible temperature sensitivity of the gel, and the hydrogel did not affect the photothermal properties of Ti3C2 nanoparticles. The in vitro and in vivo results show that this hydrogel system can effectively inhibit tumor growth upon exposure to near-infrared irradiation with excellent biocompatibility and biosafety. The photothermal agent-embedded hydrogel is a promising photothermal therapeutic strategy for cancer treatment by enhancing the retention in vivo and elevating the local temperature in tumors.

scholarly journals Near-Infrared Photothermal Therapy Cancer Treatment Assisted with Graphene-Based Materials

2020 ◽  
Vol 2 (2) ◽  
pp. 26
Keyword(s):  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Density Functional ◽  
Near Infrared ◽  
Density Functional Theory Calculation ◽  
Infrared Light ◽  
Light Sources ◽  
Near Infrared Light ◽  
New Material ◽  
Theory Calculation

Photothermal therapy is an emerging method of cancer treatment in which tumors are ablated by heating agents using near-infrared light (700–1000 nm). A semiconductor with a bandgap between 0.3–0.7 eV would, therefore, efficiently emit near-infrared light. The new “magic” material graphene has a bandgap of zero, which is advantageous with regard to designing a new material with a suitable bandgap for the emission of near-infrared light. In our investigations, using the first-principles density functional theory calculation method, we aimed to and successfully designed graphene-based materials with a direct bandgap of 0.68 eV. They have the potential to be optimal and efficient near-infrared light sources due to their narrow yet fitting bandgap. The present results open up a new avenue for the application of graphene-based materials to assist in photothermal therapy.

scholarly journals An On-Demand pH-Sensitive Nanocluster for Cancer Treatment by Combining Photothermal Therapy and Chemotherapy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 839 ◽  
Author(s):  
Taehoon Sim ◽  
Chaemin Lim ◽  
Ngoc Ha Hoang ◽  
Yuseon Shin ◽  
Jae Chang Kim ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Therapeutic Effect ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Ph Sensitive ◽  
Systemic Toxicity ◽  
Infrared Light ◽  
Nc System ◽  
On Demand ◽  
Ph Sensitive Polymer

Combination therapy is considered to be a promising strategy for improving the therapeutic efficiency of cancer treatment. In this study, an on-demand pH-sensitive nanocluster (NC) system was prepared by the encapsulation of gold nanorods (AuNR) and doxorubicin (DOX) by a pH-sensitive polymer, poly(aspartic acid-graft-imidazole)-PEG, to enhance the therapeutic effect of chemotherapy and photothermal therapy. At pH 6.5, the NC systems formed aggregated structures and released higher drug amounts while sustaining a stable nano-assembly, structured with less systemic toxicity at pH 7.4. The NC could also increase antitumor efficacy as a result of improved accumulation and release of DOX from the NC system at pHex and pHen with locally applied near-infrared light. Therefore, an NC system would be a potent strategy for on-demand combination treatment to target tumors with less systemic toxicity and an improved therapeutic effect.

A pH-sensitive nanoagent self-assembled from a highly negative-charged phthalocyanine with excellent biosafety for photothermal therapy

2021 ◽  
Author(s):  
Bing-De Zheng ◽  
Zhenliang Huang ◽  
Li-Li Lv ◽  
Wen-Liang Lan ◽  
Jia-Qian Hu ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Ph Sensitive ◽  
Highly Efficient ◽  
Promising Strategy ◽  
Self Assembled

Photothermal therapy (PTT) is a promising strategy for cancer treatment. However, development of highly efficient photothermal agents with excellent biosafety, particularly with low liver retention, is very meaningful for clinical...

131I-labeled gold nanoframeworks for radiotherapy-combined second near-infrared photothermal therapy of cancer

2021 ◽  
Author(s):  
Danling Cheng ◽  
Jiali Gong ◽  
Peng Wang ◽  
Jingyi Zhu ◽  
Ningyue Yu ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Heat Generation ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Great Promise ◽  
Anticancer Efficacy

Photothermal therapy (PTT) has shown a great promise for cancer treatment via light-triggered heat generation, while the anticancer efficacy of sole PTT is often limited. In this study, we report...

Application of lanthanide-doped upconversion nanoparticles for cancer treatment: a review

Nanomedicine ◽  
2021 ◽  
Author(s):  
Yu-Qi Liu ◽  
Li-Ying Qin ◽  
Hong-Jiao Li ◽  
Yi-Xi Wang ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Uv Light ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Chemotherapy Drugs ◽  
New Ideas

With the excellent ability to transform near-infrared light to localized visible or UV light, thereby achieving deep tissue penetration, lanthanide ion-doped upconversion nanoparticles (UCNP) have emerged as one of the most striking nanoscale materials for more effective and safer cancer treatment. Up to now, UCNPs combined with photosensitive components have been widely used in the delivery of chemotherapy drugs, photodynamic therapy and photothermal therapy. Applications in these directions are reviewed in this article. We also highlight microenvironmental tumor monitoring and precise targeted therapies. Then we briefly summarize some new trends and the existing challenges for UCNPs. We hope this review can provide new ideas for future cancer treatment based on UCNPs.

Sign in / Sign up

Export Citation Format

Share Document