Near Infrared Photothermal Conversion Materials: Mechanism, Preparation and Photothermal Cancer Therapy Applications

2021 ◽  
Author(s):  
Jie Li ◽  
Wei Zhang ◽  
Wenhui Ji ◽  
Jiqing Wang ◽  
Nanxiang Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Therapeutic Effect ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Photothermal Conversion ◽  
Non Invasive ◽  
Good Therapeutic Effect ◽  
Conversion Materials ◽  
Localized Treatment

Photothermal therapy (PTT) has been widely applied in cancer therapy as a result of its non-invasive, localized treatment and good therapeutic effect. In general, the final therapeutic effect of PTT...

scholarly journals Enzyme-Loaded pH-Sensitive Photothermal Hydrogels for Mild-temperature-mediated Combinational Cancer Therapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Jindong Xia ◽  
Xueqin Qing ◽  
Junjian Shen ◽  
Mengbin Ding ◽  
Yue Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Ph Sensitive ◽  
Photothermal Effect ◽  
Photothermal Conversion ◽  
Normal Tissues ◽  
Turn On ◽  
Shock Proteins ◽  
Mild Temperature

Photothermal therapy (PTT) that utilizes hyperthermia to ablate cancer cells is a promising approach for cancer therapy, while the generated high temperature may lead to damage of surrounding normal tissues and inflammation. We herein report the construction of glucose oxidase (GOx)-loaded hydrogels with a pH-sensitive photothermal conversion property for combinational cancer therapy at mild-temperature. The hydrogels (defined as CAG) were formed via coordination of alginate solution containing pH-sensitive charge-transfer nanoparticles (CTNs) as the second near-infrared (NIR-II) photothermal agents and GOx. In the tumor sites, GOx was gradually released from CAG to consume glucose for tumor starvation and aggravate acidity in tumor microenvironment that could turn on the NIR-II photothermal conversion property of CTNs. Meanwhile, the released GOx could suppress the expression of heat shock proteins to enable mild NIR-II PTT under 1,064 nm laser irradiation. As such, CAG mediated a combinational action of mild NIR-II PTT and starvation therapy, not only greatly inhibiting the growth of subcutaneously implanted tumors in a breast cancer murine model, but also completely preventing lung metastasis. This study thus provides an enzyme loaded hydrogel platform with a pH-sensitive photothermal effect for mild-temperature-mediated combinational cancer therapy.

Novel phthalocyanine-based polymeric micelles with high near-infrared photothermal conversion efficiency under 808 nm laser irradiation for in vivo cancer therapy

2019 ◽  
Vol 7 (14) ◽  
pp. 2247-2251 ◽  
Author(s):  
Lu Li ◽  
Qingzhu Yang ◽  
Lei Shi ◽  
Nannan Zheng ◽  
Zeyu Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Conversion Efficiency ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Polymeric Micelles ◽  
Photothermal Conversion ◽  
Phthalocyanine Molecule

Novel phthalocyanine molecule 4OCSPC with deep NIR absorbance showed excellent photothermal therapy property for cancer cells.

Bioactive engineered photothermal nanomaterials: from theoretical understanding to cutting-edge application strategies in anti-cancer therapy

2021 ◽  
Author(s):  
Fu-Cheng Gao ◽  
Zhiwei Sun ◽  
Li Zhao ◽  
Fan Chen ◽  
Martina Heide Stenzel ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Photothermal Therapy ◽  
Treatment Method ◽  
Cutting Edge ◽  
Theoretical Understanding ◽  
Photothermal Conversion ◽  
Non Invasive ◽  
Anti Cancer ◽  
Therapeutic Mechanism

Photothermal therapy is an emerging treatment method for fighting cancers with characteristics of non-invasive. Its therapeutic mechanism is utilizing photothermal conversion agents (PTAs) to absorb the energy of photon and...

Bi19S27I3 nanorods: a new candidate for photothermal therapy in the first and second biological near-infrared windows

Nanoscale ◽  
2021 ◽  
Author(s):  
Jinsong Xiong ◽  
Qinghuan Bian ◽  
Shuijin Lei ◽  
Yatian Deng ◽  
Kehan Zhao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Research Interest ◽  
The Past ◽  
Nir Light ◽  
Considerable Research ◽  
Key Factor

Near-infrared (NIR) light induced photothermal cancer therapy using nanomaterials as photothermal agents has attracted considerable research interest over the past few years. As the key factor in the photothermal therapy...

Near-infrared Inorganic Nanomaterials-based Nanosystem for Photothermal Therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Yufei Wang ◽  
Hongmin Meng ◽  
Zhaohui Li
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Strong Absorption ◽  
Non Invasive ◽  
Inorganic Nanomaterials

The development of robust materials for treating diseases through non-invasive photothermal therapy (PTT) has attracted increasing attention in recent years. Among many types of nanomaterials, inorganic nanomaterials with strong absorption...

Coconut-shell-derived activated carbon for NIR photo-activated synergistic photothermal-chemodynamic cancer therapy

2021 ◽  
Author(s):  
Gang Wu ◽  
Bao Jiang ◽  
Lin Zhou ◽  
Ao Wang ◽  
Shaohua Wei
Keyword(s):  
Activated Carbon ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Carbon Nanoparticles ◽  
Coconut Shell ◽  
Photothermal Conversion

Activated carbon nanoparticles (ANs) were synthesized from coconut shell. ANs show peroxidase and photothermal conversion activities, allowing synergistic cancer treatment via chemodynamic therapy (CDT) and photothermal therapy (PTT).

scholarly journals Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Songtao Zhang ◽  
Longhai Jin ◽  
Jianhua Liu ◽  
Yang Liu ◽  
Tianqi Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Bovine Serum Albumin ◽  
Synergistic Effect ◽  
Bovine Serum ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Photothermal Effect ◽  
Reaction Efficiency

AbstractIn spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction (i.e., chemodynamic therapy, CDT) has been attracted more attentions in recent years, the limited Fenton reaction efficiency is the important obstacle to further application in clinic. Herein, we synthesized novel FeO/MoS2 nanocomposites modified by bovine serum albumin (FeO/MoS2-BSA) with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS2 nanosheets triggered by the second near-infrared (NIR II) light. In the tumor microenvironments, the MoS2 nanosheets not only can accelerate the conversion of Fe3+ ions to Fe2+ ions by Mo4+ ions on their surface to improve Fenton reaction efficiency, but also endow FeO/MoS2-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy (PTT). Consequently, benefiting from the synergetic-enhanced CDT/PTT, the tumors are eradicated completely in vivo. This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT.

scholarly journals Melanoma Cancer Therapy Using PEGylated Nanoparticles and Semiconductor Laser

2021 ◽  
Author(s):  
Abdorreza Asrar ◽  
Zahra Sobhani ◽  
Mohammad Ali Behnam
Keyword(s):  
Cancer Therapy ◽  
Laser Beam ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Histopathological Study ◽  
Melanoma Tumor ◽  
Tio2 Nps ◽  
Melanoma Cancer ◽  
Murine Melanoma ◽  
Pegylated Nanoparticles

Purpose: Photothermal therapy is a procedure that converts laser beam energy to heat so can disturb tumor cells. Carbon nanotubes (CNTs) have unique properties in absorption optical energy and could change optical power into heat in photothermal therapy procedures. Additionally, titanium dioxide (TiO2) NPs have a unique feature in absorbing and scattering light. Therefore, these mentioned NPs could play a synergistic role in the photothermal therapy method. Methods: CNTs and TiO2 NPs were injected into the melanoma tumor sites of cancerous mice. Then sites were excited using the laser beam (λ= 808nm, P= 2W, and I= 4W/cm2). Injected NPs caused hyperthermia in solid tumors. Tumor size assay, statistical analysis, and histopathological study of the treated cases were performed to assess the role of mentioned NPs in photothermal therapy of murine melanoma cancer. Results: The results showed that CNTs performed better than TiO2 NPs in destroying murine melanoma cancer cells in animals. Conclusion: The present study compared the photothermal activity of excited CNTs and TiO2 NPs in cancer therapy at the near-infrared spectrum of light. Tumors were destroyed selectively because of their weakened heat resistance versus normal tissue. Photothermal therapy of malignant melanoma through CNTs caused remarkable necrosis into the tumor tissues versus TiO2 NPs.

Semiconducting polymer-based nanoparticles for photothermal therapy at the second near-infrared window

2018 ◽  
Vol 54 (96) ◽  
pp. 13599-13602 ◽  
Author(s):  
Zuwu Wei ◽  
Ming Wu ◽  
Shanyou Lan ◽  
Jiong Li ◽  
Xiaolong Zhang ◽  
...  
Keyword(s):  
Light Absorption ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Strong Light ◽  
Semiconducting Polymer ◽  
Optical Window ◽  
Photothermal Conversion ◽  
Infrared Window

We designed novel diketopyrrolopyrrole polymer based nanoparticles (DPP-IID-FA), which exhibited strong light absorption and excellent photothermal conversion in the NIR optical window, and displayed high biocompatibility and photostability.

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