Near-infrared Inorganic Nanomaterials-based Nanosystem for Photothermal Therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Yufei Wang ◽  
Hongmin Meng ◽  
Zhaohui Li
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Strong Absorption ◽  
Non Invasive ◽  
Inorganic Nanomaterials

The development of robust materials for treating diseases through non-invasive photothermal therapy (PTT) has attracted increasing attention in recent years. Among many types of nanomaterials, inorganic nanomaterials with strong absorption...

scholarly journals Bioinspired carrier-free peptide conjugated BF2-oxasmaragdyrin dye-based nano self-assemblies: a photostable NIR cancer theragnostic agent

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Kandala Laxman ◽  
B. Pradeep K. Reddy ◽  
Sumit K. Mishra ◽  
Andrea Robinson ◽  
Abhijit De ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Visible Region ◽  
Whole Body ◽  
Water Mixture ◽  
Free Peptide ◽  
Nirf Imaging ◽  
Nir Fluorescence ◽  
Inorganic Nanomaterials

AbstractPhotothermal therapy (PTT) has attracted great interest in cancer treatment, and the quest for potential organic photothermal agents is underway owing to the nonbiodegradable nature and chronic toxicity of existing inorganic nanomaterials. Organic material-based nanoformulations with good photothermal and fluorescence properties in the near-infrared (NIR-I) window are scarce. However, porphyrins are one category of biocompatible systems that are advantageous for photothermal therapy but are currently based in the visible region, causing limited depth of tissue penetration and leading to compromised photothermal and near-infrared fluorescence (NIRF) imaging applications. To overcome these limitations, we report the synthesis of L,L-diphenylalanine conjugated BF2-oxasmaragdyrin (FF-BSC) and the fabrication of monodispersed spherical self-assemblies (FF-BSC NPs) using a USP class 3 solvent-water mixture. The resulting product exhibited excellent photostability (NIR exposure), multicycle photothermal efficacy, and NIR fluorescence. In vitro studies revealed good biocompatibility, efficient cellular internalization, and photothermal efficacy. Preclinical studies of these nano-self-assemblies demonstrated nontoxicity, efficient whole-body NIRF imaging, fractional passive tumor homing, and excellent photothermal tumor ablation potential. The absorbance and fluorescence of FF-BSC NPs in NIR-I make them suitable for theragnostic applications over existing porphyrins/inorganic nanomaterials for future clinical applications.

scholarly journals Near-infrared light-responsive inorganic nanomaterials for photothermal therapy

2016 ◽  
Vol 11 (3) ◽  
pp. 349-364 ◽  
Author(s):  
Zhihong Bao ◽  
Xuerong Liu ◽  
Yangdi Liu ◽  
Hongzhuo Liu ◽  
Kun Zhao
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Inorganic Nanomaterials

Ultra-homogeneous NIR-II fluorescent self-assembled nanoprobe with AIE properties for photothermal therapy of prostate cancer

Nanoscale ◽  
2021 ◽  
Author(s):  
Shengsheng Cui ◽  
Shanshan Fan ◽  
Haisong Tan ◽  
Yi Lu ◽  
Yiqian Zha ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Uniform Size ◽  
Imaging Technology ◽  
Non Invasive ◽  
Fluorescent Nanoprobe ◽  
Self Assembled

Near-infrared two-zone (NIR-II) fluorescence imaging has attracted attention as a non-invasive imaging technology that provides centimeter-level depth and micron-level resolution. However, producing a NIR-II fluorescent nanoprobe with uniform size, high...

A Green Method to Synthesize Size-Controllable Gold Nanostars for Photothermal Therapy and Photoacoustic Imaging

2021 ◽  
Vol 7 (1) ◽  
pp. 5
Author(s):  
Thi Tuong Vy Phan
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
High Efficiency ◽  
Photoacoustic Imaging ◽  
Strong Absorption ◽  
In Vitro Tests ◽  
Novel Therapy ◽  
Gold Nanostars ◽  
The Impact

Photothermal therapy (PTT) is a novel therapy for cancer treatment which is based on the conversion of photon energy into heat (>43 °C), and photoacoustic imaging (PAI) is a new bioimaging method for diagnosing and monitoring cancer. To enhance the impact depth of PTT and the signal of PAI, near-infrared (NIR)-absorbing photothermal agents are usually used. The development of novel NIR-absorbing photothermal agents with excellent properties, such as a high stability under long-term irradiation, strong absorption in the NIR range, and excellent biocompatibility, is needed in modern biomedicine. Previous research has proved that gold nanostars (AuNSs) have promising potential applications in photo-based therapies owing to their strong absorption in the NIR range and strong photothermal effects. However, the reported methods to synthesize AuNSs are complicated and toxic, which can limit its practical application. In this work, we proposed a new environmental strategy to synthesize AuNSs by using chitosan and vitamin C. Chitosan plays multiple roles, acting as stabilizing, shape-directing, and size-controllable agents in this method for the first time. The obtained AuNSs show strong NIR absorption and biocompatibility toward non-cancerous and cancerous cell lines. The in vitro tests proved the high efficiency of the obtained AuNSs in both PTT and PAI.

Near Infrared Photothermal Conversion Materials: Mechanism, Preparation and Photothermal Cancer Therapy Applications

2021 ◽  
Author(s):  
Jie Li ◽  
Wei Zhang ◽  
Wenhui Ji ◽  
Jiqing Wang ◽  
Nanxiang Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Therapeutic Effect ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Photothermal Conversion ◽  
Non Invasive ◽  
Good Therapeutic Effect ◽  
Conversion Materials ◽  
Localized Treatment

Photothermal therapy (PTT) has been widely applied in cancer therapy as a result of its non-invasive, localized treatment and good therapeutic effect. In general, the final therapeutic effect of PTT...

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