Bioactive engineered photothermal nanomaterials: from theoretical understanding to cutting-edge application strategies in anti-cancer therapy

2021 ◽  
Author(s):  
Fu-Cheng Gao ◽  
Zhiwei Sun ◽  
Li Zhao ◽  
Fan Chen ◽  
Martina Heide Stenzel ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Photothermal Therapy ◽  
Treatment Method ◽  
Cutting Edge ◽  
Theoretical Understanding ◽  
Photothermal Conversion ◽  
Non Invasive ◽  
Anti Cancer ◽  
Therapeutic Mechanism

Photothermal therapy is an emerging treatment method for fighting cancers with characteristics of non-invasive. Its therapeutic mechanism is utilizing photothermal conversion agents (PTAs) to absorb the energy of photon and...

Near Infrared Photothermal Conversion Materials: Mechanism, Preparation and Photothermal Cancer Therapy Applications

2021 ◽  
Author(s):  
Jie Li ◽  
Wei Zhang ◽  
Wenhui Ji ◽  
Jiqing Wang ◽  
Nanxiang Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Therapeutic Effect ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Photothermal Conversion ◽  
Non Invasive ◽  
Good Therapeutic Effect ◽  
Conversion Materials ◽  
Localized Treatment

Photothermal therapy (PTT) has been widely applied in cancer therapy as a result of its non-invasive, localized treatment and good therapeutic effect. In general, the final therapeutic effect of PTT...

Coconut-shell-derived activated carbon for NIR photo-activated synergistic photothermal-chemodynamic cancer therapy

2021 ◽  
Author(s):  
Gang Wu ◽  
Bao Jiang ◽  
Lin Zhou ◽  
Ao Wang ◽  
Shaohua Wei
Keyword(s):  
Activated Carbon ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Carbon Nanoparticles ◽  
Coconut Shell ◽  
Photothermal Conversion

Activated carbon nanoparticles (ANs) were synthesized from coconut shell. ANs show peroxidase and photothermal conversion activities, allowing synergistic cancer treatment via chemodynamic therapy (CDT) and photothermal therapy (PTT).

Application of Gold-Based Nanomaterials in Tumor Photothermal Therapy and Chemotherapy

2020 ◽  
Vol 16 (6) ◽  
pp. 739-762
Author(s):  
Minyu Zhou ◽  
Yunfei Zhou ◽  
Yixin Cheng ◽  
Yanqi Wu ◽  
Jun Yang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Tumor Tissue ◽  
Treatment Method ◽  
Tumor Treatment ◽  
Targeting Therapy ◽  
Photothermal Conversion ◽  
Gold Nanomaterials ◽  
Development Prospects ◽  
Therapy Treatment

Photothermal therapy (PTT) is a minimally invasive tumor treatment method in which photothermal conversion agents (PTAs) can be enriched in tumor tissue by external light stimulation to convert photon energy into thermal energy to induce the temperature of tumor tissue higher than normal physiological, and can effectively kill tumor cells and tissues while avoiding damage to healthy tissue. As a well-known biocompatible nanomaterial, gold-based nanomaterials have high photothermal conversion efficiency and cross section, which can be used in tumor targeting therapy treatment as a potential photothermal conversion agent. Combining PTT and chemotherapy can be achieved by loading a chemotherapeutic drug modified on the surface of a gold nanomaterials. Therefore, this paper first reviews the preparation and surface functionalization of Au-based nanomaterials, such as Au nanorods, Au nanostars, Au nanoshells, and so on. Second, we have also introduced the application of Au-based nanomaterials in PTT, chemotherapy, and combination therapy. Finally, the limitations and challenges of Au-based photothermal conversion agents are summarized and the development prospects in this field are prospected.

scholarly journals Enzyme-Loaded pH-Sensitive Photothermal Hydrogels for Mild-temperature-mediated Combinational Cancer Therapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Jindong Xia ◽  
Xueqin Qing ◽  
Junjian Shen ◽  
Mengbin Ding ◽  
Yue Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Ph Sensitive ◽  
Photothermal Effect ◽  
Photothermal Conversion ◽  
Normal Tissues ◽  
Turn On ◽  
Shock Proteins ◽  
Mild Temperature

Photothermal therapy (PTT) that utilizes hyperthermia to ablate cancer cells is a promising approach for cancer therapy, while the generated high temperature may lead to damage of surrounding normal tissues and inflammation. We herein report the construction of glucose oxidase (GOx)-loaded hydrogels with a pH-sensitive photothermal conversion property for combinational cancer therapy at mild-temperature. The hydrogels (defined as CAG) were formed via coordination of alginate solution containing pH-sensitive charge-transfer nanoparticles (CTNs) as the second near-infrared (NIR-II) photothermal agents and GOx. In the tumor sites, GOx was gradually released from CAG to consume glucose for tumor starvation and aggravate acidity in tumor microenvironment that could turn on the NIR-II photothermal conversion property of CTNs. Meanwhile, the released GOx could suppress the expression of heat shock proteins to enable mild NIR-II PTT under 1,064 nm laser irradiation. As such, CAG mediated a combinational action of mild NIR-II PTT and starvation therapy, not only greatly inhibiting the growth of subcutaneously implanted tumors in a breast cancer murine model, but also completely preventing lung metastasis. This study thus provides an enzyme loaded hydrogel platform with a pH-sensitive photothermal effect for mild-temperature-mediated combinational cancer therapy.

scholarly journals Melanin-Like Nanomedicine in Photothermal Therapy Applications

2021 ◽  
Vol 22 (1) ◽  
pp. 399
Author(s):  
Yale Yue ◽  
Xiao Zhao
Keyword(s):  
Photothermal Therapy ◽  
Chemical Properties ◽  
Treatment Method ◽  
The Body ◽  
Tumor Treatment ◽  
Photothermal Conversion ◽  
The Past ◽  
Internal Mechanism ◽  
Physical And Chemical ◽  
And Chemical Properties

Photothermal therapy (PTT) mediated by nanomaterial has become an attractive tumor treatment method due to its obvious advantages. Among various nanomaterials, melanin-like nanoparticles with nature biocompatibility and photothermal conversion properties have attracted more and more attention. Melanin is a natural biological macromolecule widely distributed in the body and displays many fascinating physicochemical properties such as excellent biocompatibility and prominent photothermal conversion ability. Due to the similar properties, Melanin-like nanoparticles have been extensively studied and become promising candidates for clinical application. In this review, we give a comprehensive introduction to the recent advancements of melanin-like nanoparticles in the field of photothermal therapy in the past decade. In this review, the synthesis pathway, internal mechanism and basic physical and chemical properties of melanin-like nanomaterials are systematically classified and evaluated. It also summarizes the application of melanin-like nanoparticles in bioimaging and tumor photothermal therapy (PTT)in detail and discussed the challenges they faced in clinical translation rationally. Overall, melanin-like nanoparticles still have significant room for development in the field of biomedicine and are expected to applied in clinical PTT in the future.

Novel phthalocyanine-based polymeric micelles with high near-infrared photothermal conversion efficiency under 808 nm laser irradiation for in vivo cancer therapy

2019 ◽  
Vol 7 (14) ◽  
pp. 2247-2251 ◽  
Author(s):  
Lu Li ◽  
Qingzhu Yang ◽  
Lei Shi ◽  
Nannan Zheng ◽  
Zeyu Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Conversion Efficiency ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Polymeric Micelles ◽  
Photothermal Conversion ◽  
Phthalocyanine Molecule

Novel phthalocyanine molecule 4OCSPC with deep NIR absorbance showed excellent photothermal therapy property for cancer cells.

scholarly journals Polydopamine-Coated Copper-Substituted Mesoporous Silica Nanoparticles for Dual Cancer Therapy

Coatings ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 60
Author(s):  
Prabhakar Busa ◽  
Ravindranadh Koutavarapu ◽  
Yaswanth Kuthati
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Photothermal Therapy ◽  
Water Solubility ◽  
Mesoporous Silica Nanoparticles ◽  
A549 Cells ◽  
Combinational Therapy ◽  
Anti Cancer ◽  
Cell Inhibition ◽  
Nano Formulation

Combinational therapy using chemodynamictherapy (CDT) and photothermal therapy (PTT) is known to enhance the therapeutic outcome for cancer treatment. In this study, a biocompatible nano formulation was developed by coating polydopamine (PDA) over doxorubicin (DOX)-loaded copper-substituted mesoporous silica (CuMSN) nanoparticles. PDA coating not only allowed selective photothermal properties with an extended DOX release but also enhanced the water solubility and biocompatibility of the nanocomposites. The nanocomposites displayed a monodispersed shape and pH-dependent release characteristics, with an outstanding photothermal conversion and excellent tumor cell inhibition. The cellular-uptake experiments of CuMSN@DOX@PDA in A549 cells indicated that nanoparticles (NPs) aided in the enhanced DOX uptake in tumor cells compared to free DOX with synergistic anti-cancer effects. Moreover, the cell-viability studies displayed remarkable tumor inhibition in combinational therapy over monotherapy. Thus, the synthesized CuMSN@DOX@PDA NPs can serve as a promising platform for dual cancer therapy.

scholarly journals IR 820 stabilized multifunctional polycaprolactone glycol chitosan composite nanoparticles for cancer therapy

RSC Advances ◽  
2015 ◽  
Vol 5 (69) ◽  
pp. 56162-56170 ◽  
Author(s):  
Piyush Kumar ◽  
Rohit Srivastava
Keyword(s):  
Cancer Therapy ◽  
Minimally Invasive ◽  
Thermal Ablation ◽  
Photothermal Therapy ◽  
Composite Nanoparticles ◽  
Glycol Chitosan ◽  
Non Invasive ◽  
Chitosan Composite

Photothermal therapy has gained worldwide attention for its less painful, non invasive/minimally invasive, effective thermal ablation based therapy for cancer.

Noninvasive photothermal cancer therapy nanoplatforms via integrating nanomaterials and functional polymers

2017 ◽  
Vol 5 (2) ◽  
pp. 190-210 ◽  
Author(s):  
Qingfu Ban ◽  
Ting Bai ◽  
Xiao Duan ◽  
Jie Kong
Keyword(s):  
Immune System ◽  
Side Effects ◽  
Cancer Therapy ◽  
Photothermal Therapy ◽  
Functional Polymers ◽  
Cutting Edge ◽  
Conventional Surgery ◽  
Edge Field ◽  
System P

In the cutting-edge field of cancer therapy, noninvasive photothermal therapy (PTT) has received great attention because it is considered to overcome the drawbacks of conventional surgery, radiotherapy and chemotherapy of severe body injuries and side effects on the immune system.

scholarly journals A Supramolecular Photosensitizer System Based on Nano-Cu/ZIF-8 Capped with Water-Soluble Pillar[6]arene and Methylene Blue Host–Guest Complexations

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3878
Author(s):  
Chenhao Hu ◽  
Yueyuan Yu ◽  
Shuang Chao ◽  
Huidan Zhu ◽  
Yuxin Pei ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Combination Therapy ◽  
Fenton Reaction ◽  
Water Soluble ◽  
Low Oxygen ◽  
Non Invasive ◽  
Anti Cancer

Photodynamic therapy (PDT) as a safe, non-invasive modality for cancer therapy, in which the low oxygen and high glutathione in the tumor microenvironment reduces therapeutic efficiency. In order to overcome these problems, we prepared a supramolecular photosensitive system of O2-Cu/ZIF-8@ZIF-8@WP6–MB (OCZWM), which was loaded with oxygen to increase the oxygen concentration in the tumor microenvironment, and the Cu2+ in the system reacted with glutathione (GSH) to reduce the GSH concentration to generate Cu+. It is worth noting that the generated Cu+ can produce the Fenton reaction, thus realizing the combination therapy of PDT and chemodynamic therapy (CDT) to achieve the purpose of significantly improving the anti-cancer efficiency.

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