Anti-inflammatory Properties of Cerium Oxide Nanoparticles

Small ◽  
2009 ◽  
Vol 5 (24) ◽  
pp. 2848-2856 ◽  
Author(s):  
Suzanne M. Hirst ◽  
Ajay S. Karakoti ◽  
Ron D. Tyler ◽  
Nammalwar Sriranganathan ◽  
Sudipta Seal ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Anti Inflammatory

scholarly journals Different approaches to synthesise cerium oxide nanoparticles and their corresponding physical characteristics, ROS scavenging and anti-inflammatory capabilities

2021 ◽  
Author(s):  
Yuao Wu ◽  
Hang Thu Ta
Keyword(s):  
Cerium Oxide ◽  
Physical Characteristics ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Biological Applications ◽  
Ros Scavenging ◽  
Trivalent Cerium ◽  
Anti Inflammatory ◽  
Tetravalent Cerium

The biological applications of cerium oxide nanoparticles (nanoceria) have received extensive attention in recent decades. The coexistence of trivalent cerium and tetravalent cerium on the surface of nanoceria allows the...

Cerium oxide nanoparticles reduce steatosis, portal hypertension and display anti-inflammatory properties in rats with liver fibrosis

2016 ◽  
Vol 64 (3) ◽  
pp. 691-698 ◽  
Author(s):  
Denise Oró ◽  
Tetyana Yudina ◽  
Guillermo Fernández-Varo ◽  
Eudald Casals ◽  
Vedrana Reichenbach ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Liver Fibrosis ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Anti Inflammatory

scholarly journals The Anti-oxidant and Anti-inflammatory Properties of Cerium Oxide Nanoparticles Synthesized Using Origanum majorana L. Leaf Extract

2019 ◽  
Vol 4 (3) ◽  
pp. 108-112
Author(s):  
Ali Es-haghi ◽  
Saynaz Aseyd Nezhad
Keyword(s):  
Free Radicals ◽  
Cerium Oxide ◽  
Leaf Extract ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Gene Expressions ◽  
Frap Assay ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Origanum Majorana

Introduction: Free radicals have singlet electron in their outer layer rendering them high reactivity against biomolecules (i.e., DNA, carbohydrates, proteins, and lipids). Oxidative stress is created when the production of free radicals exceeds their removal by antioxidant systems and is involved in the pathogenesis of several diseases such as diabetes, arthritis, inflammatory conditions, and various cancers. Regarding the therapeutic potential of nanoparticles (NPs) in human diseases, the purpose of this study was to synthesize cerium oxide NPs using Origanum majorana leaf extract. Methods: Cerium oxide nanoparticles (CeO2 -NPs) were synthesized using aqueous leaf extract of O. majorana. The sizes of NPs were characterized by a particle size analyzer. The antioxidant properties of the CeO2 -NPs were determined by Ferric-reducing antioxidant power (FRAP) assay. The anti-inflammatory effects of the NPs were also determined by measuring gene expressions of IL-1β and IL-10 using real-time polymerase chain reaction (PCR). Results: The CeO2 -NPs were successfully synthesized using O. majorana leaf extract. The results of FRAP assay showed that the anti-oxidant activities of CeO2 -NPs at concentrations of 50, 100, and 400 μg/mL were 75%, 77.1%, and 94.5%, respectively. Moreover, interleukin 10 (IL-10) gene expressions increased by 4.6 folds while the expression of IL-1β gene decreased by 0.75-fold in HUVECs. Conclusion: The CeO2 -NPs synthesized using the aqueous extract of O. majorana demonstrated antioxidant and anti-inflammatory properties. Therefore, these NPs can be used as potential therapeutic agents in medicine.

scholarly journals Anti-inflammatory and antioxidant effects of cerium oxide nanoparticles in human endothelial cells

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P4174-P4174 ◽  
Author(s):  
S. Del Turco ◽  
G. Ciofani ◽  
V. Cappello ◽  
T. Navarra ◽  
C. Caselli ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Human Endothelial Cells ◽  
Anti Inflammatory ◽  
Antioxidant Effects

Polyacrylic Acid Modified Cerium Oxide Nanoparticles: Synthesis and Characterization as a Peroxidase Mimic for Non-Enzymatic H2O2 Sensor

2020 ◽  
Vol 16 (5) ◽  
pp. 816-828
Author(s):  
Gurdeep Rattu ◽  
Nishtha Khansili ◽  
Prayaga M. Krishna
Keyword(s):  
Hydrogen Peroxide ◽  
Cerium Oxide ◽  
Polyacrylic Acid ◽  
Spectroscopic Analysis ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Peroxidase Mimic ◽  
Ft Ir ◽  
H2o2 Sensing ◽  
Fluorescence Spectrometer

Background: Cerium oxide nanoparticles (nanoceria) are efficient free-radical scavengers due to their dual valence state and thus exhibit optical and catalytic properties. Therefore, the main purpose of this work was to understand the peroxidase mimic activity of polymer-stabilized nanoceria for enzyme-less H2O2 sensing by fluorescence spectrometer. Objective: This research revealed the development of fluorescence hydrogen peroxide nanosensor based on the peroxidase-like activity of polyacrylic acid stabilized nanoceria (PAA-CeO2 Nps). Methods: PAA-CeO2 Nps were synthesized by simple cross-linking reaction at a low temperature and characterized by XRD, SEM, Zeta potential, TGA, FT-IR and UV-VIS spectroscopic analysis. H2O2 sensing was performed by a fluorescence spectrometer. Results:: The synthesized polymer nanocomposite was characterized by XRD, SEM, TGA, FT-IR and UV-VIS spectroscopic analysis. The XRD diffraction patterns confirmed the polycrystalline nature and SEM micrograph showed nanoparticles having hexagonal symmetry and crystallite size of 32 nm. The broad peak of Ce–O bond appeared at 508 cm-1. UV-VIS measurements revealed a welldefined absorbance peak around 315 nm and an optical band-gap of 3.17 eV. As synthesized PAACeO2 Nps effectively catalysed the decomposition of hydrogen peroxide (H2O2) into hydroxyl radicals. Then terephthalic acid was oxidized by hydroxyl radical to form a highly fluorescent product. Under optimized conditions, the linear range for determination of hydrogen peroxide was 0.01 - 0.2 mM with a limit of detection (LOD) of 1.2 μM. Conclusion: The proposed method is ideally suited for the sensing of H2O2 at a low cost and this detection system enabled the sensing of analytes (sugars), which can enzymatically generate hydrogen peroxide.

Radiosensitizing Effect of Cerium Oxide Nanoparticles on Human Leukemia Cells

2018 ◽  
Vol 6 (2) ◽  
pp. 111-115 ◽  
Author(s):  
Azadeh Montazeri ◽  
Zohreh Zal ◽  
Arash Ghasemi ◽  
Hooman Yazdannejat ◽  
Hossein Asgarian-Omran ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Leukemia Cells ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Human Leukemia ◽  
Radiosensitizing Effect ◽  
Human Leukemia Cells

Cerium oxide nanoparticles acts as a novel therapeutic agent for ulcerative colitis through anti-oxidative mechanism

Life Sciences ◽  
2021 ◽  
pp. 119500
Author(s):  
Fereshteh Asgharzadeh ◽  
Alireza Hashemzadeh ◽  
Farzad Rahmani ◽  
Atieh Yaghoubi ◽  
Seyedeh Elnaz Nazari ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Cerium Oxide ◽  
Therapeutic Agent ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Novel Therapeutic
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