Recent advances in metal-organic frameworks (MOFs) for biomimetic cell membrane tumor therapy

Author(s):  
Jian-Qiang Liu ◽  
Weicong Liu ◽  
Abhinav Kumar ◽  
Ying Pan ◽  
Xia Chen ◽  
...  

In order to improve the tumor-targeting ability of metal-organic frameworks (MOFs) for tumor therapy and to avoid the clearance as well as capture by the immune system, there are still...

Author(s):  
Weicong Liu ◽  
Qianwen Yan ◽  
Chen Xia ◽  
Xiaoxiong Wang ◽  
Abhinav Kumar ◽  
...  

Correction for ‘Recent advances in cell membrane coated metal–organic frameworks (MOFs) for tumor therapy’ by Weicong Liu et al., J. Mater. Chem. B, 2021, DOI: 10.1039/d1tb00453k.


RSC Advances ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 3241-3263
Author(s):  
Junlei Yang ◽  
Hui Wang ◽  
Jinyao Liu ◽  
Mengkui Ding ◽  
Xianjin Xie ◽  
...  

This review provides an overview of the recent advances in nano-MOFs for drug delivery and tumor therapy and some insight into present challenges and prospects.


2021 ◽  
Vol 34 ◽  
pp. 102179
Author(s):  
Nokubonga Makhanya ◽  
Bilainu Oboirien ◽  
Jianwei Ren ◽  
Nicholas Musyoka ◽  
Adriano Sciacovelli

2021 ◽  
pp. 118274
Author(s):  
Mohamed E. Mahmoud ◽  
Sarah M. Elsayed ◽  
Safe ELdeen M.E. Mahmoud ◽  
Reham O. Aljedaani ◽  
Mohamed Abdel Salam

2021 ◽  
Author(s):  
Bei Li ◽  
Dongsheng Zhao ◽  
Feng Wang ◽  
Xiaoxian Zhang ◽  
Wenqian Li ◽  
...  

This review covers the latest advancements of molecular logic gates based on LMOF. The classification, design strategies, related sensing mechanisms, future developments, and challenges of LMOFs-based logic gates are discussed.


2021 ◽  
Author(s):  
Tania HIDALGO ◽  
Rosana Simón-Vázquez ◽  
africa González-Fernández ◽  
Patricia Horcajada

Human body is continuously in a never-ending chess game against pathogens. When the immune system, our natural defense tool, is weakened, these organisms are able to escape, collapsing the body...


2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Chao Yan ◽  
Yue Jin ◽  
Chuanxiang Zhao

AbstractNanoparticles as drug delivery systems can alter the drugs' hydrophilicity to affect drug uptake and efflux in tissues. They prevent drugs from non-specifically binding with bio-macromolecules and enhance drug accumulation at the lesion sites, improving therapy effects and reducing unnecessary side effects. Metal–organic frameworks (MOFs), the typical nanoparticles, a class of crystalline porous materials via self-assembled organic linkers and metal ions, exhibit excellent biodegradability, pore shape and sizes, and finely tunable chemical composition. MOFs have a rigid molecular structure, and tunable pore size can improve the encapsulation drug's stability under harsh conditions. Besides, the surface of MOFs can be modified with small-molecule ligands and biomolecule, and binding with the biomarkers which is overexpressed on the surface of cancer cells. MOFs formulations for therapeutic have been developed to effectively respond to the unique tumor microenvironment (TEM), such as high H2O2 levels, hypoxia, and high concentration glutathione (GSH). Thus, MOFs as a drug delivery system should avoid drugs leaking during blood circulation and releasing at the lesion sites via a controlling manner. In this article, we will summary environment responsive MOFs as drug delivery systems for tumor therapy under different stimuli.


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