scholarly journals Recent advances in nanosized metal organic frameworks for drug delivery and tumor therapy

RSC Advances ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 3241-3263
Author(s):  
Junlei Yang ◽  
Hui Wang ◽  
Jinyao Liu ◽  
Mengkui Ding ◽  
Xianjin Xie ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Therapy ◽  
Metal Organic Frameworks ◽  
Recent Advances ◽  
Metal Organic ◽  
Insight Into

This review provides an overview of the recent advances in nano-MOFs for drug delivery and tumor therapy and some insight into present challenges and prospects.

scholarly journals Environment Responsive Metal–Organic Frameworks as Drug Delivery System for Tumor Therapy

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Chao Yan ◽  
Yue Jin ◽  
Chuanxiang Zhao
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Tumor Therapy ◽  
Metal Organic Frameworks ◽  
Delivery Systems ◽  
Drug Uptake ◽  
High Concentration ◽  
Metal Organic

AbstractNanoparticles as drug delivery systems can alter the drugs' hydrophilicity to affect drug uptake and efflux in tissues. They prevent drugs from non-specifically binding with bio-macromolecules and enhance drug accumulation at the lesion sites, improving therapy effects and reducing unnecessary side effects. Metal–organic frameworks (MOFs), the typical nanoparticles, a class of crystalline porous materials via self-assembled organic linkers and metal ions, exhibit excellent biodegradability, pore shape and sizes, and finely tunable chemical composition. MOFs have a rigid molecular structure, and tunable pore size can improve the encapsulation drug's stability under harsh conditions. Besides, the surface of MOFs can be modified with small-molecule ligands and biomolecule, and binding with the biomarkers which is overexpressed on the surface of cancer cells. MOFs formulations for therapeutic have been developed to effectively respond to the unique tumor microenvironment (TEM), such as high H2O2 levels, hypoxia, and high concentration glutathione (GSH). Thus, MOFs as a drug delivery system should avoid drugs leaking during blood circulation and releasing at the lesion sites via a controlling manner. In this article, we will summary environment responsive MOFs as drug delivery systems for tumor therapy under different stimuli.

Combined experimental and theoretical insight into the drug delivery of nanoporous metal–organic frameworks

RSC Advances ◽  
2015 ◽  
Vol 5 (104) ◽  
pp. 85606-85612 ◽  
Author(s):  
Jiaping Wang ◽  
Juncheng Jin ◽  
Fumei Li ◽  
Baohong Li ◽  
Jianqiang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Level ◽  
Load Capacity ◽  
Metal Organic Frameworks ◽  
Void Space ◽  
Drug Load ◽  
Nanoporous Metal ◽  
Metal Organic ◽  
Theoretical Insight ◽  
Insight Into

The comparison between calculated drug load values and some molecular level properties indicates the existence of a relationship between the void space of material and drug load capacity.

Recent advances in metal-organic frameworks (MOFs) for biomimetic cell membrane tumor therapy

2021 ◽  
Author(s):  
Jian-Qiang Liu ◽  
Weicong Liu ◽  
Abhinav Kumar ◽  
Ying Pan ◽  
Xia Chen ◽  
...  
Keyword(s):  
Immune System ◽  
Cell Membrane ◽  
Tumor Targeting ◽  
Tumor Therapy ◽  
Metal Organic Frameworks ◽  
Recent Advances ◽  
Metal Organic ◽  
Targeting Ability

In order to improve the tumor-targeting ability of metal-organic frameworks (MOFs) for tumor therapy and to avoid the clearance as well as capture by the immune system, there are still...

Nanoscale metal–organic frameworks for drug delivery: a conventional platform with new promise

2018 ◽  
Vol 6 (5) ◽  
pp. 707-717 ◽  
Author(s):  
Lei Wang ◽  
Min Zheng ◽  
Zhigang Xie
Keyword(s):  
Drug Delivery ◽  
Metal Organic Frameworks ◽  
Delivery Systems ◽  
Recent Advances ◽  
Cargo Delivery ◽  
Metal Organic

This review highlights recent advances made using nanoscale metal–organic frameworks (NMOFs) for designing cargo-delivery systems.

scholarly journals Correction: Recent advances in cell membrane coated metal–organic frameworks (MOFs) for tumor therapy

2021 ◽  
Author(s):  
Weicong Liu ◽  
Qianwen Yan ◽  
Chen Xia ◽  
Xiaoxiong Wang ◽  
Abhinav Kumar ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Tumor Therapy ◽  
Metal Organic Frameworks ◽  
Recent Advances ◽  
Coated Metal ◽  
Metal Organic

Correction for ‘Recent advances in cell membrane coated metal–organic frameworks (MOFs) for tumor therapy’ by Weicong Liu et al., J. Mater. Chem. B, 2021, DOI: 10.1039/d1tb00453k.

Quantum Mechanical Interpretation of the Ultra-Low Energy Methyl-Rotation Dynamics in Porous Metal-Organic Frameworks Probed by Low-Frequency Vibrational Spectroscopy and ab initio Simulations

2018 ◽  
Author(s):  
Qi Li ◽  
Adam J. Zaczek ◽  
Timothy M. Korter ◽  
J. Axel Zeitler ◽  
Michael T. Ruggiero
Keyword(s):  
Ab Initio ◽  
Metal Organic Frameworks ◽  
Low Frequency ◽  
Rotor Dynamics ◽  
Quantum Mechanical ◽  
Valuable Insight ◽  
Void Space ◽  
Ab Initio Simulations ◽  
Metal Organic ◽  
Insight Into

<div>Understanding the nature of the interatomic interactions present within the pores of metal-organic frameworks</div><div>is critical in order to design and utilize advanced materials</div><div>with desirable applications. In ZIF-8 and its cobalt analogue</div><div>ZIF-67, the imidazolate methyl-groups, which point directly</div><div>into the void space, have been shown to freely rotate - even</div><div>down to cryogenic temperatures. Using a combination of ex-</div><div>perimental terahertz time-domain spectroscopy, low-frequency</div><div>Raman spectroscopy, and state-of-the-art ab initio simulations,</div><div>the methyl-rotor dynamics in ZIF-8 and ZIF-67 are fully charac-</div><div>terized within the context of a quantum-mechanical hindered-</div><div>rotor model. The results lend insight into the fundamental</div><div>origins of the experimentally observed methyl-rotor dynamics,</div><div>and provide valuable insight into the nature of the weak inter-</div><div>actions present within this important class of materials.</div>

Recent advances on thermal energy storage using metal-organic frameworks (MOFs)

2021 ◽  
Vol 34 ◽  
pp. 102179
Author(s):  
Nokubonga Makhanya ◽  
Bilainu Oboirien ◽  
Jianwei Ren ◽  
Nicholas Musyoka ◽  
Adriano Sciacovelli
Keyword(s):  
Energy Storage ◽  
Thermal Energy ◽  
Thermal Energy Storage ◽  
Metal Organic Frameworks ◽  
Recent Advances ◽  
Metal Organic

Smart metal organic frameworks: Focus on cancer treatment

2021 ◽  
Author(s):  
Monir Falsafi ◽  
Amir Shokooh Saljooghi ◽  
Khalil Abnous ◽  
Seyed Mohammad Taghdisi ◽  
Mohammad Ramezani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Porous Materials ◽  
Metal Clusters ◽  
Metal Organic Frameworks ◽  
Controlled Systems ◽  
Metal Organic

Metal–organic frameworks (MOFs), as a prominent category of hybrid porous materials constructed from metal clusters or ions plus organic linkers, have been broadly employed as controlled systems of drug delivery...

Sign in / Sign up

Export Citation Format

Share Document