Co-delivery of anionic epitope/CpG vaccine and IDO inhibitor by self-assembled cationic liposome for combination melanoma immunotherapy

2021 ◽  
Author(s):  
Qi Su ◽  
Changrong Wang ◽  
Huijuan Song ◽  
Chuangnian Zhang ◽  
Jinjian Liu ◽  
...  
Keyword(s):  
Immune Responses ◽  
Cancer Treatment ◽  
Cancer Immunotherapy ◽  
Cationic Liposome ◽  
Antigenic Peptides ◽  
Promising Strategy ◽  
Self Assembled

Immunotherapy is revolutionizing cancer treatment. Vaccination of antigenic peptides has been identified as a promising strategy for cancer immunotherapy while insufficient immune responses were stimulated due to low antigenicity. Moreover,...

A pH-sensitive nanoagent self-assembled from a highly negative-charged phthalocyanine with excellent biosafety for photothermal therapy

2021 ◽  
Author(s):  
Bing-De Zheng ◽  
Zhenliang Huang ◽  
Li-Li Lv ◽  
Wen-Liang Lan ◽  
Jia-Qian Hu ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Ph Sensitive ◽  
Highly Efficient ◽  
Promising Strategy ◽  
Self Assembled

Photothermal therapy (PTT) is a promising strategy for cancer treatment. However, development of highly efficient photothermal agents with excellent biosafety, particularly with low liver retention, is very meaningful for clinical...

scholarly journals Chitin, Chitosan, and Glycated Chitosan Regulate Immune Responses: The Novel Adjuvants for Cancer Vaccine

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Xiaosong Li ◽  
Min Min ◽  
Nan Du ◽  
Ying Gu ◽  
Tomas Hode ◽  
...  
Keyword(s):  
Immune Responses ◽  
Cancer Treatment ◽  
Cancer Immunotherapy ◽  
Cancer Vaccine ◽  
Future Development ◽  
Chitosan Nanoparticles ◽  
The Novel ◽  
Chitin And Chitosan

With the development of cancer immunotherapy, cancer vaccine has become a novel modality for cancer treatment, and the important role of adjuvant has been realized recently. Chitin, chitosan, and their derivatives have shown their advantages as adjuvants for cancer vaccine. In this paper, the adjuvant properties of chitin and chitosan were discussed, and some detailed information about glycated chitosan and chitosan nanoparticles was also presented to illustrate the trend for future development.

scholarly journals Oncolytic Virus Immunotherapy: Showcasing Impressive Progress in Special Issue II

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 663
Author(s):  
Zong-Sheng Guo
Keyword(s):  
Cancer Immunotherapy ◽  
Oncolytic Virus ◽  
Advanced Stage ◽  
Special Issue ◽  
Promising Strategy

Cancer immunotherapy has recently become the most promising strategy for hard-to-treat, advanced-stage malignancies [...]

scholarly journals Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Cheng-Tao Jiang ◽  
Kai-Ge Chen ◽  
An Liu ◽  
Hua Huang ◽  
Ya-Nan Fan ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Immune Responses ◽  
Cancer Immunotherapy ◽  
Tumor Cells ◽  
Noncovalent Interactions ◽  
Killer Cell ◽  
Antibody Immobilization ◽  
Effector Cells ◽  
Nanoparticle Surface

AbstractModulating effector immune cells via monoclonal antibodies (mAbs) and facilitating the co-engagement of T cells and tumor cells via chimeric antigen receptor- T cells or bispecific T cell-engaging antibodies are two typical cancer immunotherapy approaches. We speculated that immobilizing two types of mAbs against effector cells and tumor cells on a single nanoparticle could integrate the functions of these two approaches, as the engineered formulation (immunomodulating nano-adaptor, imNA) could potentially associate with both cells and bridge them together like an ‘adaptor’ while maintaining the immunomodulatory properties of the parental mAbs. However, existing mAbs-immobilization strategies mainly rely on a chemical reaction, a process that is rough and difficult to control. Here, we build up a versatile antibody immobilization platform by conjugating anti-IgG (Fc specific) antibody (αFc) onto the nanoparticle surface (αFc-NP), and confirm that αFc-NP could conveniently and efficiently immobilize two types of mAbs through Fc-specific noncovalent interactions to form imNAs. Finally, we validate the superiority of imNAs over the mixture of parental mAbs in T cell-, natural killer cell- and macrophage-mediated antitumor immune responses in multiple murine tumor models.

Design of Novel Photosensitizers and Controlled Singlet Oxygen Generation for Photodynamic Therapy

2021 ◽  
Author(s):  
Esra Tanrıverdi Eçik ◽  
Onur BULUT ◽  
Hasan Hüseyin Kazan ◽  
Elif Şenkuytu ◽  
Bunyemin Cosut
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Side Effect ◽  
Side Effect Profile ◽  
High Ability ◽  
Lower Side ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Promising Strategy

Photodynamic therapy (PDT) is a promising strategy in cancer treatment with its relatively lower side effect profile. Undoubtedly, the key component of PDT is the photosensitizers with a high ability...

In situ injection of dual-delivery PEG based MMP-2 sensitive hydrogels for enhanced tumor penetration and chemo-immune combination therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Jianqin Yan ◽  
Zhuangzhuang Zhang ◽  
xiaohui Zhan ◽  
Keqi Chen ◽  
Yuji Pu ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Cancer Treatment ◽  
Deep Penetration ◽  
Tumor Penetration ◽  
Dna Nanostructure ◽  
Promising Strategy

mproving the deep penetration of nanoparticles and realizing the combination of chemotherapy and immunotherapy have become a promising strategy for cancer treatment. Herein, nuclear-targeted tetrahedral DNA nanostructure (NLS-TDNs, NT) was...

Tumor Microenvironment-Triggered In-Situ Cancer Vaccines with Dual Immunogenic Cell Death Inductions for Elevated Antitumor and Antimetastatic Therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Jun Lin ◽  
Binbin Ding ◽  
Pan Zheng ◽  
Dong Li ◽  
Meifang Wang ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Microenvironment ◽  
Immune Responses ◽  
Cancer Immunotherapy ◽  
Cancer Vaccines ◽  
High Specificity ◽  
The Body ◽  
Immunogenic Cell Death ◽  
Specific Antigens

Cancer vaccine is to make tumor-specific antigens into vaccines, which then are injected back into the body to activate immune responses for cancer immunotherapy. Despite the high specificity and therapeutic...

scholarly journals Bovine serum albumin-loaded nano-selenium/ICG nanoparticles for highly effective chemo-photothermal combination therapy

RSC Advances ◽  
2017 ◽  
Vol 7 (49) ◽  
pp. 30717-30724 ◽  
Author(s):  
Guanjun Deng ◽  
Ting Zhu ◽  
Lihua Zhou ◽  
Jingnan Zhang ◽  
Sanpeng Li ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Combination Therapy ◽  
Serum Albumin ◽  
Cancer Treatment ◽  
Bovine Serum ◽  
Promising Strategy ◽  
Highly Effective

Chemo-photothermal combination therapy has already become a promising strategy for cancer treatment.

scholarly journals Design and Encapsulation of Immunomodulators onto Gold Nanoparticles in Cancer Immunotherapy

2021 ◽  
Vol 22 (15) ◽  
pp. 8037
Author(s):  
Akshita Chauhan ◽  
Tabassum Khan ◽  
Abdelwahab Omri
Keyword(s):  
Immune System ◽  
Immune Responses ◽  
Cancer Immunotherapy ◽  
Cytotoxic T Lymphocytes ◽  
Recent Progress ◽  
Checkpoint Inhibitors ◽  
Drug Clearance ◽  
Cell Permeability ◽  
Plasmonic Effect ◽  
Cancer Immunotherapeutic

The aim of cancer immunotherapy is to reactivate autoimmune responses to combat cancer cells. To stimulate the immune system, immunomodulators, such as adjuvants, cytokines, vaccines, and checkpoint inhibitors, are extensively designed and studied. Immunomodulators have several drawbacks, such as drug instability, limited half-life, rapid drug clearance, and uncontrolled immune responses when used directly in cancer immunotherapy. Several strategies have been used to overcome these limitations. A simple and effective approach is the loading of immunomodulators onto gold-based nanoparticles (GNPs). As gold is highly biocompatible, GNPs can be administered intravenously, which aids in increasing cancer cell permeability and retention time. Various gold nanoplatforms, including nanospheres, nanoshells, nanorods, nanocages, and nanostars have been effectively used in cancer immunotherapy. Gold nanostars (GNS) are one of the most promising GNP platforms because of their unusual star-shaped geometry, which significantly increases light absorption and provides high photon-to-heat conversion efficiency due to the plasmonic effect. As a result, GNPs are a useful vehicle for delivering antigens and adjuvants that support the immune system in killing tumor cells by facilitating or activating cytotoxic T lymphocytes. This review represents recent progress in encapsulating immunomodulators into GNPs for utility in a cancer immunotherapeutic regimen.

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