A pH-sensitive nanoagent self-assembled from a highly negative-charged phthalocyanine with excellent biosafety for photothermal therapy

2021 ◽  
Author(s):  
Bing-De Zheng ◽  
Zhenliang Huang ◽  
Li-Li Lv ◽  
Wen-Liang Lan ◽  
Jia-Qian Hu ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Ph Sensitive ◽  
Highly Efficient ◽  
Promising Strategy ◽  
Self Assembled

Photothermal therapy (PTT) is a promising strategy for cancer treatment. However, development of highly efficient photothermal agents with excellent biosafety, particularly with low liver retention, is very meaningful for clinical...

Highly efficient near-infrared BODIPY phototherapeutic nanoparticles for cancer treatment

2020 ◽  
Vol 8 (24) ◽  
pp. 5305-5311
Author(s):  
Yuandong Zhang ◽  
Zhiyu Yang ◽  
Xiaohua Zheng ◽  
Li Chen ◽  
Zhigang Xie
Keyword(s):  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Highly Efficient

A highly efficient NIR BODIPY nano-photosensitizer constructed by multi-intersection effects provides beneficial guidance for photodynamic and photothermal therapy.

scholarly journals An On-Demand pH-Sensitive Nanocluster for Cancer Treatment by Combining Photothermal Therapy and Chemotherapy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 839 ◽  
Author(s):  
Taehoon Sim ◽  
Chaemin Lim ◽  
Ngoc Ha Hoang ◽  
Yuseon Shin ◽  
Jae Chang Kim ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Therapeutic Effect ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Ph Sensitive ◽  
Systemic Toxicity ◽  
Infrared Light ◽  
Nc System ◽  
On Demand ◽  
Ph Sensitive Polymer

Combination therapy is considered to be a promising strategy for improving the therapeutic efficiency of cancer treatment. In this study, an on-demand pH-sensitive nanocluster (NC) system was prepared by the encapsulation of gold nanorods (AuNR) and doxorubicin (DOX) by a pH-sensitive polymer, poly(aspartic acid-graft-imidazole)-PEG, to enhance the therapeutic effect of chemotherapy and photothermal therapy. At pH 6.5, the NC systems formed aggregated structures and released higher drug amounts while sustaining a stable nano-assembly, structured with less systemic toxicity at pH 7.4. The NC could also increase antitumor efficacy as a result of improved accumulation and release of DOX from the NC system at pHex and pHen with locally applied near-infrared light. Therefore, an NC system would be a potent strategy for on-demand combination treatment to target tumors with less systemic toxicity and an improved therapeutic effect.

Co-delivery of anionic epitope/CpG vaccine and IDO inhibitor by self-assembled cationic liposome for combination melanoma immunotherapy

2021 ◽  
Author(s):  
Qi Su ◽  
Changrong Wang ◽  
Huijuan Song ◽  
Chuangnian Zhang ◽  
Jinjian Liu ◽  
...  
Keyword(s):  
Immune Responses ◽  
Cancer Treatment ◽  
Cancer Immunotherapy ◽  
Cationic Liposome ◽  
Antigenic Peptides ◽  
Promising Strategy ◽  
Self Assembled

Immunotherapy is revolutionizing cancer treatment. Vaccination of antigenic peptides has been identified as a promising strategy for cancer immunotherapy while insufficient immune responses were stimulated due to low antigenicity. Moreover,...

NIR-active Nanoterminator with Mature Dendritic Cell Acitivities for Immuno-Priming Mild Photothermal Cancer Therapy

2020 ◽  
Author(s):  
zhihong sun ◽  
Guanjun Deng ◽  
Xinghua Peng ◽  
Xiuli Xu ◽  
Lanlan Liu ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Photothermal Therapy ◽  
Whole Body ◽  
Mature Dendritic Cell ◽  
Immune Microenvironment ◽  
Highly Efficient ◽  
Tumor Immune Microenvironment ◽  
Shock Proteins ◽  
Mild Temperature ◽  
Broad Interest

Recently, photothermal-immuno synergistic therapy under mild temperature (~ 45 °C) has got broad interest in cancer treatment. Inhibition the intratumorally HSPs production is the key to accomplish highly efficient and mild photothermal therapy. In this work, we developed biomimetic nanoterminators with mature DCs functions by coating the mature dendritic cell membrane on photothermal nanoagents. As-prepared nanoterminators could automatically locate on T cell in the complex tumor-immune microenvironment and promote the T cells proliferation, activation and cytokine secretion, which could not only inhibit the expression of heat shock proteins to cooperate on highly efficient mild photothermal therapy (~42°C), but also promote tumor apoptosis during the treatment. More importantly, this nanoterminator could serve as vaccine to trigger anti-tumor immune response of the whole body, which would be promising to long-life tumor inhibition and termination.

Design of Novel Photosensitizers and Controlled Singlet Oxygen Generation for Photodynamic Therapy

2021 ◽  
Author(s):  
Esra Tanrıverdi Eçik ◽  
Onur BULUT ◽  
Hasan Hüseyin Kazan ◽  
Elif Şenkuytu ◽  
Bunyemin Cosut
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Side Effect ◽  
Side Effect Profile ◽  
High Ability ◽  
Lower Side ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Promising Strategy

Photodynamic therapy (PDT) is a promising strategy in cancer treatment with its relatively lower side effect profile. Undoubtedly, the key component of PDT is the photosensitizers with a high ability...

In situ injection of dual-delivery PEG based MMP-2 sensitive hydrogels for enhanced tumor penetration and chemo-immune combination therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Jianqin Yan ◽  
Zhuangzhuang Zhang ◽  
xiaohui Zhan ◽  
Keqi Chen ◽  
Yuji Pu ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Cancer Treatment ◽  
Deep Penetration ◽  
Tumor Penetration ◽  
Dna Nanostructure ◽  
Promising Strategy

mproving the deep penetration of nanoparticles and realizing the combination of chemotherapy and immunotherapy have become a promising strategy for cancer treatment. Herein, nuclear-targeted tetrahedral DNA nanostructure (NLS-TDNs, NT) was...

Coconut-shell-derived activated carbon for NIR photo-activated synergistic photothermal-chemodynamic cancer therapy

2021 ◽  
Author(s):  
Gang Wu ◽  
Bao Jiang ◽  
Lin Zhou ◽  
Ao Wang ◽  
Shaohua Wei
Keyword(s):  
Activated Carbon ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Carbon Nanoparticles ◽  
Coconut Shell ◽  
Photothermal Conversion

Activated carbon nanoparticles (ANs) were synthesized from coconut shell. ANs show peroxidase and photothermal conversion activities, allowing synergistic cancer treatment via chemodynamic therapy (CDT) and photothermal therapy (PTT).

scholarly journals Carambola-like Bi2Te3 superstructures with enhanced photoabsorption for highly efficient photothermal therapy in the sencond biowindow

2021 ◽  
Author(s):  
Yinghui Wang ◽  
Ying Zhao ◽  
Yang Liu ◽  
Qishun Wang ◽  
Jianhua Liu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Highly Efficient ◽  
Penetration Ability ◽  
Maximum Permissible Exposure

Photothermal therapy (PTT) stimulated by the lights in the second near-infrared (NIR-II) biowindow shows great superiorities in penetration ability of tissue and maximum permissible exposure (MPE). Exploring new photothermal agents...

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