scholarly journals Controlled viscoelastic particle encapsulation in microfluidic devices

Soft Matter ◽  
2021 ◽  
Author(s):  
Keshvad Shahrivar ◽  
Francesco Del Giudice
Keyword(s):  
Biomedical Engineering ◽  
Material Science ◽  
Microfluidic Devices ◽  
Encapsulation Process ◽  
Particle Encapsulation

The encapsulation of particles in droplets using microfluidic devices finds application across several fields ranging from biomedical engineering to material science. The encapsulation process, however, is often affected by poor...

Force modeling to develop a novel method for fabrication of hollow channels inside a gel structure

2019 ◽  
Vol 234 (2) ◽  
pp. 223-231 ◽  
Author(s):  
Ranjit Barua ◽  
Himanshu Giria ◽  
Sudipto Datta ◽  
Amit Roy Chowdhury ◽  
Pallab Datta
Keyword(s):  
Viscoelastic Material ◽  
Biomedical Engineering ◽  
Viscoelastic Properties ◽  
Three Dimensional ◽  
Microfluidic Devices ◽  
Robotic Arm ◽  
Complex Geometries ◽  
Gel Structure ◽  
Force Modeling ◽  
Novel Method

Fabrication of hollow channels with user-defined dimensions and patterns inside viscoelastic, gel-type materials is required for several applications, especially in biomedical engineering domain. These include objectives of obtaining vascularized tissues and enclosed or subsurface microfluidic devices. However, presently there is no suitable manufacturing technology that can create such channels and networks in a gel structure. The advent of three-dimensional bioprinting has opened new possibilities for fabricating structures with complex geometries. However, application of this technique to fabricate internal hollow channels in viscoelastic material has not been yet explored to a great extent. In this article, we present the theoretical modeling/background of a proposed manufacturing paradigm through which hollow channels can be conveniently fabricated inside a gel structure. We propose that a tip connected to a robotic arm can be moved in X-, Y-, and Z-axis as per the desired design. The tip can be moved by a magnet or mechanical force. If the tip is further trailed with porous tube and moved inside the viscoelastic material, corresponding internal channels can be fabricated. To achieve this, however, force modeling to understand the forces that will be required to move the tip inside viscoelastic material should be known and understood. Therefore, in our first attempt, we developed the computational force modeling of the tip movement inside gels with different viscoelastic properties to create the channels.

scholarly journals Microfluidic formation of crystal-like structures

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Francesco Del Giudice ◽  
Gaetano D'Avino ◽  
Pier Luca Maffettone
Keyword(s):  
High Throughput ◽  
Biomedical Engineering ◽  
Material Science ◽  
Material Synthesis

Crystal-like structures find application in several fields ranging from biomedical engineering to material science. For instance, droplet crystals are critical for high throughput assays and material synthesis, while particle crystals...

Nanotechnologies in tissue engineering

2013 ◽  
Vol 2 (4) ◽  
pp. 411-425 ◽  
Author(s):  
Amir K. Bigdeli ◽  
Stefan Lyer ◽  
Rainer Detsch ◽  
Aldo R. Boccaccini ◽  
Justus P. Beier ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Biomedical Engineering ◽  
Material Science ◽  
Cell Biology ◽  
Vascular Grafts ◽  
New Materials ◽  
Engineering Applications ◽  
Interdisciplinary Field ◽  
Biomimetic Approach

AbstractAs an interdisciplinary field, tissue engineering (TE) aims to regenerate tissues by combining the principles of cell biology, material science, and biomedical engineering. Nanotechnology creates new materials that might enable further tissue-engineering applications. In this context, the introduction of nanotechnology and nanomaterials promises a biomimetic approach by mimicking nature. This review summarizes the current scope of nanotechnology implementation possibilities in the field of tissue engineering of bone, muscle, and vascular grafts with forms on nanofibrous structures.

Two-dimensional biomaterials: material science, biological effect and biomedical engineering applications

2021 ◽  
Author(s):  
Hui Huang ◽  
Wei Feng ◽  
Yu Chen
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Engineering ◽  
Material Science ◽  
Biological Effect ◽  
Two Dimensional ◽  
Engineering Applications ◽  
Physiochemical Property ◽  
Two Dimensional Materials ◽  
Cancer Theranostics

Two-dimensional materials have attracted explosive interests in biomedicine, including biosensing, imaging, drug delivery, cancer theranostics, and tissue engineering, stemming from their unique morphology, physiochemical property, and biological effect.

scholarly journals Nanomaterials Synthesis through Microfluidic Methods: An Updated Overview

Nanomaterials ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 864 ◽  
Author(s):  
Adelina-Gabriela Niculescu ◽  
Cristina Chircov ◽  
Alexandra Cătălina Bîrcă ◽  
Alexandru Mihai Grumezescu
Keyword(s):  
Material Science ◽  
Reaction Times ◽  
Microfluidic Devices ◽  
Synthesis Methods ◽  
Biological Processes ◽  
Scientific Interest ◽  
New Era ◽  
Nanomaterials Synthesis ◽  
Reaction Vessels

Microfluidic devices emerged due to an interdisciplinary “collision” between chemistry, physics, biology, fluid dynamics, microelectronics, and material science. Such devices can act as reaction vessels for many chemical and biological processes, reducing the occupied space, equipment costs, and reaction times while enhancing the quality of the synthesized products. Due to this series of advantages compared to classical synthesis methods, microfluidic technology managed to gather considerable scientific interest towards nanomaterials production. Thus, a new era of possibilities regarding the design and development of numerous applications within the pharmaceutical and medical fields has emerged. In this context, the present review provides a thorough comparison between conventional methods and microfluidic approaches for nanomaterials synthesis, presenting the most recent research advancements within the field.

scholarly journals Fabrication and Applications of Microfluidic Devices: A Review

2021 ◽  
Vol 22 (4) ◽  
pp. 2011
Author(s):  
Adelina-Gabriela Niculescu ◽  
Cristina Chircov ◽  
Alexandra Cătălina Bîrcă ◽  
Alexandru Mihai Grumezescu
Keyword(s):  
Fluid Dynamics ◽  
Cell Culture ◽  
Material Science ◽  
Biomedical Applications ◽  
Microfluidic Devices ◽  
Cell Analysis ◽  
Microfluidic Chips ◽  
Drug Encapsulation ◽  
Microfluidic Technology ◽  
Nanoparticle Preparation

Microfluidics is a relatively newly emerged field based on the combined principles of physics, chemistry, biology, fluid dynamics, microelectronics, and material science. Various materials can be processed into miniaturized chips containing channels and chambers in the microscale range. A diverse repertoire of methods can be chosen to manufacture such platforms of desired size, shape, and geometry. Whether they are used alone or in combination with other devices, microfluidic chips can be employed in nanoparticle preparation, drug encapsulation, delivery, and targeting, cell analysis, diagnosis, and cell culture. This paper presents microfluidic technology in terms of the available platform materials and fabrication techniques, also focusing on the biomedical applications of these remarkable devices.

Application of electron holography to material science studies on magnetic domain states of small particles

1993 ◽  
Vol 51 ◽  
pp. 1028-1029
Author(s):  
T. Hirayama ◽  
Q. Ru ◽  
T. Tanji ◽  
A. Tonomura
Keyword(s):  
Magnetic Field ◽  
Material Science ◽  
Science Studies ◽  
Phase Distribution ◽  
Carbon Film ◽  
Objective Lens ◽  
Electron Holography ◽  
Transform Method ◽  
Transmission Electron ◽  
Thin Carbon

The observation of small magnetic materials is one of the most important applications of electron holography to material science, because interferometry by means of electron holography can directly visualize magnetic flux lines in a very small area. To observe magnetic structures by transmission electron microscopy it is important to control the magnetic field applied to the specimen in order to prevent it from changing its magnetic state. The easiest method is tuming off the objective lens current and focusing with the first intermediate lens. The other method is using a low magnetic-field lens, where the specimen is set above the lens gap.Figure 1 shows an interference micrograph of an isolated particle of barium ferrite on a thin carbon film observed from approximately [111]. A hologram of this particle was recorded by the transmission electron microscope, Hitachi HF-2000, equipped with an electron biprism. The phase distribution of the object electron wave was reconstructed digitally by the Fourier transform method and converted to the interference micrograph Fig 1.

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