scholarly journals Photoredox-Mediated Hydroalkylation and Hydroarylation of Functionalized Olefins for DNA-Encoded Library Synthesis

2021 ◽  
Author(s):  
Shorouk O. Badir ◽  
Alexander Lipp ◽  
Matthias Krumb ◽  
María Jesús Cabrera-Afonso ◽  
Lisa Marie Kammer ◽  
...  
Keyword(s):  
Pharmaceutical Industry ◽  
Cost Effective ◽  
Library Synthesis

DNA-encoded library (DEL) technology features a time- and cost-effective interrogation format for the discovery of therapeutic candidates in the pharmaceutical industry. To develop DEL platforms, the implementation of water-compatible transformations...

scholarly journals Sales Professionals’ Perspective on Digital Marketing in Indian Pharmaceutical Industry

2019 ◽  
Vol 8 (1) ◽  
pp. 80-84
Author(s):  
Manoj Kumar ◽  
Bhausaheb Londhe
Keyword(s):  
Pharmaceutical Industry ◽  
Digital Technology ◽  
Effective Means ◽  
Cost Effective ◽  
Digital Marketing ◽  
Major Transitions ◽  
Sales Professionals ◽  
Awareness Campaigns ◽  
The World ◽  
Indian Pharmaceutical Industry

Indian pharmaceutical industry is one amongst the leading players of pharmaceutical industry around the world. In present digital times, every aspect of the society has been digitalized. There are major transitions noted in pharmaceutical industry as well. Digital technology, has changed the working methods and emerged, as a cost effective means, with impressive target reach around the world. Yet, this platform, is not being utilized to its complete potential, due to the lack of awareness, acceptability and the deficient training of the working personnel. The marketing and sales professionals had a major impact of the digitalization on their working methods. It has changed the traditional marketing methods of industry, resulting in the urgent need of up-gradation of the skills of sales professionals. Hence, the views, trainings, awareness and acceptability of sales professionals regarding the digital technology is essential and must be kept into consideration for success of the industry. This is an indispensable component for any pharmaceutical company to attain growth and stand at par with the other pharmaceutical giants around the world. In this study, data of 303 sales professionals was collected and analyzed, recording their perspectives on digital marketing. We found that these professionals were aware and had good acceptability for the same. Most commonly used tools were website promotions, social media advertising, awareness campaigns, creation and management of subject related blogs. These professionals used it extensively on a day-to-day basis, for the maximal benefit of the company with providing the comfort of digitalization to their customers and other users.

scholarly journals Doctor and pharmacist — back to the apothecary!

2009 ◽  
Vol 33 (2) ◽  
pp. 268 ◽  
Author(s):  
Siaw-Teng Liaw ◽  
Gregory Peterson
Keyword(s):  
Pharmaceutical Industry ◽  
Health Professionals ◽  
Multidisciplinary Approach ◽  
Cost Effective ◽  
Governance Structure ◽  
Close Monitoring ◽  
Unintended Effects ◽  
Quality Use Of Medicines ◽  
Ongoing Training ◽  
Timely Access

The Australian National Medicines Policy embodies four tenets: availability, quality, safety and efficacy of medicines; timely access to affordable medicines; quality use of medicines (QUM); and a responsible and viable medicines industry. The promotion of QUM requires a multidisciplinary approach, including contributions from government, the pharmaceutical industry, health professionals, consumers and academia. However, there are significant tensions and unintended effects associated with the multidisciplinary approach, especially with the relationships between prescribers and dispensers of medicines. The general practitioner and the pharmacist share a common ancestor ? the apothecary. The separation of dispensing from prescribing, which began in medieval Europe and 19th century England, reframed and confined the patient?doctor relationship to one of diagnosis, prescription and non-drug management. The role of pharmacists was limited to dispensing, though the present trend is for their responsibilities to be widened. Historical antecedents, the contribution of an increasing number of actors to the costs of health care, universal health insurance and an evolving regulatory framework, are among the factors influencing doctor?pharmacist relations. The prescribing and dispensing of medicines must be guided by an ethical clinical governance structure encompassing health professionals, regulators, the pharmaceutical industry and consumers. There must be close monitoring of safety and effectiveness, and promotion of quality use of medicines and improved patient outcomes. Ongoing training and professional development, within and across professional boundaries, is essential to support harmonious and cost-effective interprofessional practice. The approach must be ?apothecarial? with complementary roles and responsibilities for the prescriber and dispenser within the patient?clinician therapeutic relationship, and not adversarial.

scholarly journals Competitive intelligence in the South African pharmaceutical industry

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
A. Fatti ◽  
A.S.A. Du Toit
Keyword(s):  
Decision Making ◽  
Pharmaceutical Industry ◽  
South African ◽  
Cost Effective ◽  
Strategic Decision ◽  
Competitive Intelligence ◽  
Strategic Decision Making ◽  
The South ◽  
Continuous Basis ◽  
The Government

Currently the South African pharmaceutical industry is being affected by legislation, as the government is readjusting the whole healthcare system to make it cost-effective and equitable. The purpose of this article is to establish what the current situation is within the South African pharmaceutical’s industry’s competitive intelligence (CI) capacity. Questionnaires were administered electronically to senior managers in the pharmaceutical industry. The majority of the respondents were of the opinion that a culture of information sharing and an environment of collaboration on competitive issues exist in their companies. Respondents confirm that CI is used on a continuous basis in strategic decision-making and that company strategies are used to manage competitors. It is recommended that senior management of pharmaceutical companies capitalise and consolidate the CI function which is used on a continuous basis in strategic decision-making.

scholarly journals Photochemical C–H Arylation of Heteroarenes for DNA-Encoded Library Synthesis

2022 ◽  
Author(s):  
Matthias Krumb ◽  
Lisa Marie Kammer ◽  
Shorouk O. Badir ◽  
María Jesús Cabrera-Afonso ◽  
Victoria E. Wu ◽  
...  
Keyword(s):  
Pharmaceutical Industry ◽  
Efficient Technique ◽  
Library Synthesis ◽  
Cost Efficient

DNA-encoded library (DEL) technology has emerged as a time- and cost-efficient technique for the identification of therapeutic candidates in the pharmaceutical industry. Although several reaction classes have been successfully validated...

Significance of Green Synthetic Chemistry from a Pharmaceutical Perspective

2020 ◽  
Vol 26 (45) ◽  
pp. 5767-5782
Author(s):  
Haseeb Ahsan ◽  
Salman Ul Islam ◽  
Muhammad Bilal Ahmed ◽  
Young Sup Lee ◽  
Jong Kyung Sonn
Keyword(s):  
Pharmaceutical Industry ◽  
Green Chemistry ◽  
Tertiary Education ◽  
Cost Effective ◽  
Drug Approval ◽  
Sustainable Environment ◽  
Conventional Drug ◽  
Drug Synthesis ◽  
Manufacturing Techniques ◽  
Green Synthetic Chemistry

Background: Conventional practices of synthesis, manufacturing, and processing have led to severe adverse consequences for living beings and the environment. Objectives: Although medications cannot be replaced, the methods of synthesizing, manufacturing, and processing them can be changed and/or replaced. This paper explains the significance of green chemistry practices in the pharmaceutical industry. It emphasizes that we must replace conventional drug synthesis, processing, and manufacturing techniques with greener ones that are cost-effective, sustainable, environment-friendly, and profitable. Discussion: This paper comprises five sections. Section 1 is an introduction to green chemistry and its correlation with the pharmaceutical industry. Section 2 discusses the metrics necessary to measure the greenness of a process. Section 3 is about solvents used in the pharmaceutical industry, hazards, safety status, and environmental effects, including the ozone depletion potential. Section 4 explains catalytic amidation reactions because amides are one of the most commonly occurring functional groups with pharmacological activity. Section 5 discusses successful cases of converting conventional synthesis of active pharmaceutical ingredients and/or their intermediates to greener, sustainable alternatives. Conclusion: A balance is necessary between profits, processes, consumers, and the environment to ensure the survival of all stakeholders and decrease the environmental burden of pharmaceuticals. Incentives such as green chemistry awards should be endorsed and encouraged, in addition to making green chemistry part of tertiary education. In addition, changes to rules and regulations for drug approval in the context of green chemistry principles are necessary in order to preserve our planet for future generations.

Comparative effectiveness research and the rise of orphan indications

2014 ◽  
Vol 8 (2) ◽  
pp. 151-163
Author(s):  
Sarah Jeffers ◽  
Mark Slomiany ◽  
Rema Bitar ◽  
Sarah Kruse ◽  
Mahmud Hassan
Keyword(s):  
Pharmaceutical Industry ◽  
Rare Disease ◽  
Affordable Care Act ◽  
Comparative Effectiveness Research ◽  
Comparative Effectiveness ◽  
Cost Effective ◽  
Orphan Drugs ◽  
Effectiveness Research ◽  
Content Type ◽  
The Affordable Care Act

Purpose – The purpose of this paper is to show the link between the comparative effectiveness research (CER) and the interest in developing drugs for rare disease by the pharmaceutical industry. Total healthcare spending is on the rise without having a corresponding better health outcome. As such, with the growing role of government in healthcare, measuring and demonstrating value is beginning to expand beyond the private sector to metrics applied in the public sector. A modern approach to comparative effective research began its rapid rise in the USA when the American Recovery and Reinvestment Act of 2009 allocated $1.1 billion for CER. This paper analyzes the implication and impact on the pharmaceutical industry. Design/methodology/approach – The paper reviews the basic definitions of CER and its areas of strength and weakness. It used real examples of drugs to show the impact of the Reinvestment Act of 2009 on the rise of orphan drugs. Findings – The study shows that the act encouraged the development of orphan drugs, mainly because of the low budget impact due to a smaller patient base. Provisions of the Affordable Care Act provide incentives for such rare disease indications, as no one can be denied coverage with pre-existing conditions. Research limitations/implications – The study is limited by the number of available rare drugs and the ongoing process of implementation of the Affordable Care Act. Practical implications – The study shows the cost-effective method of treating medical conditions. Social implications – Development of orphan drugs opens up access to care for many patients at a cost-effective price. Originality/value – This paper shows the link between the CER and the interest in developing drugs for rare disease by the pharmaceutical industry. It also brings out the possible implication of the Affordable Care Act on the pharmaceutical industry with respect to its strategies for drug development and drug portfolio.

scholarly journals TRIM21 chimeric protein as a new molecular tool for multispecies IgG detection

2021 ◽  
Author(s):  
Anelize Ramos ◽  
Leonardo Fernandes ◽  
Franciane Batista ◽  
Maria Risoleta Freire Marques ◽  
Jacó Joaquim Mattos ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Pharmaceutical Industry ◽  
Chimeric Protein ◽  
Cost Effective ◽  
Laboratory Animals ◽  
Affinity Ligands ◽  
Molecular Tool ◽  
Bacterial Proteins ◽  
High Affinity ◽  
Wide Range

G-type immunoglobulins (IgGs) are extensively used in the pharmaceutical industry against various diseases, being also crucial in multiple immunoassays. The production of secondary monoclonal antibodies (Abs) for IgG detection is not cost-effective, while polyclonal antibody production still depends on laboratory animals, which raises concerns regarding animal welfare. As alternatives, bacterial proteins (A and G) have been widely exploited; however, several difficulties are encountered regarding their use for IgG detection and purification. The widespread use of IgGs in the pharmaceutical industry and the increasing number and variety of new Abs entering the market impose the need to develop new detection and purification strategies. The TRIM21 protein is a soluble intracellular IgG receptor that binds to the Fc region of many species with high affinity. We created a chimeric protein containing a mutated form of the C-terminal domain of mouse TRIM21 linked to a streptavidin moiety to detect IgGs from a wide range of species. The protein is promptly produced by heterologous expression and consists of an improved molecular tool, expanding the portfolio of Ab-affinity ligands for immunoassays.

scholarly journals IMPROVEMENT OF PHARMACEUTICAL SPECIALISTS DURING THE PERIOD OF REFORMING MEDICINE AND PHARMACY IN UKRAINE

2020 ◽  
Vol 5 (41) ◽  
pp. 26
Author(s):  
I. M. Belay ◽  
V. I. Dary ◽  
V. O. Demchenko ◽  
A. I. Belay ◽  
N. P. Krasko ◽  
...  
Keyword(s):  
Higher Education ◽  
Pharmaceutical Industry ◽  
Medical Care ◽  
Cost Effective ◽  
Main Element ◽  
High Quality ◽  
System A ◽  
High Quality Medical Care ◽  
Quality Medical Care

The article describes the need to determine the main directions and priorities of the development of the pharmaceutical industry in Ukraine, which is conditioned by real political and socioeconomic processes. The main element here is the introduction and development of a formular system - a complex of management methods for the application of rational, organizational and cost-effective methods of supplying and using drugs to ensure, in specific conditions, high quality medical care and optimal use of available resources.Key words: pharmaceutical industry, pharmacist, pharmacist, higher education.

scholarly journals A Bird View of Chemistry Role in the Drugs Discovery from the Pharmaceutical Industry

2021 ◽  
Vol 8 (S1-Feb) ◽  
pp. 77-80
Author(s):  
Dakshayini C ◽  
Jyothsna Karanth
Keyword(s):  
Pharmaceutical Industry ◽  
Large Scale ◽  
Cost Effective ◽  
Chemical Substances ◽  
Synthetic Procedure

The major role of chemistry in the formation of chemical substances from the pharmaceutical industry, the compounds that are extracted from the plants or the synthetic procedure to synthesize, which were of medicinal importance, but medicinal values are often obtained only in very minimal amounts. Therefore, to encourage production on a large-scale, they should be less cost-effective and novel, degradable products.

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