scholarly journals Photochemical C–H Arylation of Heteroarenes for DNA-Encoded Library Synthesis

2022 ◽  
Author(s):  
Matthias Krumb ◽  
Lisa Marie Kammer ◽  
Shorouk O. Badir ◽  
María Jesús Cabrera-Afonso ◽  
Victoria E. Wu ◽  
...  

DNA-encoded library (DEL) technology has emerged as a time- and cost-efficient technique for the identification of therapeutic candidates in the pharmaceutical industry. Although several reaction classes have been successfully validated...

1995 ◽  
Vol 26 (2) ◽  
pp. 335-341 ◽  
Author(s):  
Thomas H. Marwick ◽  
Terry Anderson ◽  
M.John Williams ◽  
Brian Haluska ◽  
Jacques A. Melin ◽  
...  

2014 ◽  
Vol 11 ◽  
pp. 154-166 ◽  
Author(s):  
Hao Di ◽  
Vishal Anand ◽  
Dan Liao ◽  
Du Xu ◽  
Lemin Li ◽  
...  

2021 ◽  
Author(s):  
Shorouk O. Badir ◽  
Alexander Lipp ◽  
Matthias Krumb ◽  
María Jesús Cabrera-Afonso ◽  
Lisa Marie Kammer ◽  
...  

DNA-encoded library (DEL) technology features a time- and cost-effective interrogation format for the discovery of therapeutic candidates in the pharmaceutical industry. To develop DEL platforms, the implementation of water-compatible transformations...


2021 ◽  
pp. 227797522110034
Author(s):  
Saswati Tripathi ◽  
Bijoy Talukder ◽  
Krishnamachari Rangarajan

The competitive nature of the pharmaceutical industry necessitates that its multifaceted supply-chain be cost-efficient and profitable. This paper aims to ascertain the critical supply-chain financial indicators influencing pharmaceutical-supply-chain (PSC) performance, revealing its unique features and assessing these indicators’ effect on profitability. This paper measures the PSC performance of 55 public-limited Indian pharmaceutical firms, including multinational enterprises, integrating supply-chain financial variables and SCOR KPIs through a ten-year timeline. The critical supply-chain-performance indicators (SCPIs) are identified from the measured set through factor analysis. A panel data random effect model is developed, linking these critical SCPIs and profitability to understand their significant influence on profitability. This paper has evidenced the existence of three critical SCPIs, revealing working capital efficiency, material flow efficiency and investment efficiency. It has also proved the significant influence of these SCPIs on firms’ profitability and has brought out the importance of material flow efficiency in terms of inventory and distribution efficiency as a leading contributing factor for profitability. This paper contributes to finding key PSC performance features and their vital role in pharmaceutical firms’ profitability. Supply-chain managers can enhance PSC’s specific performance areas to be cost-efficient and can increase the firm’s profitability.


Increasing sustainability is the objective in all manufacturing and service sectors. For the increasing sustainability via circular economy, the research at hand reviews reverse logistics within the pharmaceutical industry of Pakistan. It proposes a recommendation to improve the current process of recycling medicines. The methodology is a qualitative method comprising unstructured interviews with an esteemed organization and observations to understand the dynamics of recycling and reverse logistics in drugs. The study helps develop and illustrates a framework divided into three stages (Distributor/Hospitals in 1st Tier, Whole sellers in 2nd Tier, Retailers and Customer in 3rd Tier) to target the customers and bring them into reverse logistics. The paper recommends policy implications to help improve the situation and initiate a sustainable practice for the environment and cost-efficient, including steps wise phases to gauge consumers for recycling medicines.


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