scholarly journals NIR-II Cell Endocytosis-Activated Fluorescent Probes For In Vivo High-Contrast Bioimaging Diagnostics

2021 ◽  
Author(s):  
Fan Zhang ◽  
Yue He ◽  
Shangfeng Wang ◽  
Peng Yu ◽  
Kui Yan ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Clinical Diagnostics ◽  
Fluorescence Probes ◽  
High Contrast ◽  
Background Interference

Fluorescence probes have great potential to empower bioimaging, precision clinical diagnostics and surgery. However, current probes have been limited for in vivo high-contrast diagnostics, due to substantial background interference from...

A General Strategy for Development of Activatable NIR‐II Fluorescent Probes for In Vivo High‐Contrast Bioimaging

2020 ◽  
Vol 133 (2) ◽  
pp. 813-818
Author(s):  
Tian‐Bing Ren ◽  
Zhi‐Yao Wang ◽  
Zhen Xiang ◽  
Peng Lu ◽  
Huan‐Hua Lai ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
General Strategy ◽  
High Contrast

A General Strategy for Development of Activatable NIR‐II Fluorescent Probes for In Vivo High‐Contrast Bioimaging

2020 ◽  
Vol 60 (2) ◽  
pp. 800-805 ◽  
Author(s):  
Tian‐Bing Ren ◽  
Zhi‐Yao Wang ◽  
Zhen Xiang ◽  
Peng Lu ◽  
Huan‐Hua Lai ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
General Strategy ◽  
High Contrast

scholarly journals Non-invasive diagnostics in fossils - Magnetic Resonance Imaging of pathological belemnites

2005 ◽  
Vol 2 (2) ◽  
pp. 133-140 ◽  
Author(s):  
D. Mietchen ◽  
H. Keupp ◽  
B. Manz ◽  
F. Volke
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Soft Tissue ◽  
Clinical Diagnostics ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Physiological Processes ◽  
Magnetic Resonance Imaging Mri ◽  
Invasive Diagnostics

Abstract. For more than a decade, Magnetic Resonance Imaging (MRI) has been routinely employed in clinical diagnostics because it allows non-invasive studies of anatomical structures and physiological processes in vivo and to differentiate between healthy and pathological states, particularly of soft tissue. Here, we demonstrate that MRI can likewise be applied to fossilized biological samples and help in elucidating paleopathological and paleoecological questions: Five anomalous guards of Jurassic and Cretaceous belemnites are presented along with putative paleopathological diagnoses directly derived from 3D MR images with microscopic resolution. Syn vivo deformities of both the mineralized internal rostrum and the surrounding former soft tissue can be traced back in part to traumatic events of predator-prey-interactions, and partly to parasitism. Besides, evidence is presented that the frequently observed anomalous apical collar might be indicative of an inflammatory disease. These findings highlight the potential of Magnetic Resonance techniques for further paleontological applications.

scholarly journals Correction: A short PEG linker alters the in vivo pharmacokinetics of trastuzumab to yield high-contrast immuno-PET images

2021 ◽  
Author(s):  
Woonghee Lee ◽  
Kondapa Naidu Bobba ◽  
Jung Young Kim ◽  
Hyun Park ◽  
Abhinav Bhise ◽  
...  
Keyword(s):  
High Contrast ◽  
In Vivo Pharmacokinetics

Correction for ‘A short PEG linker alters the in vivo pharmacokinetics of trastuzumab to yield high-contrast immuno-PET images’ by Woonghee Lee et al., J. Mater. Chem. B, 2021, 9, 2993–2997, DOI: 10.1039/D0TB02911D.

scholarly journals INSPECTOR: free software for magnetic resonance spectroscopy data inspection, processing, simulation and analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Martin Gajdošík ◽  
Karl Landheer ◽  
Kelley M. Swanberg ◽  
Christoph Juchem
Keyword(s):  
Magnetic Resonance ◽  
Quality Management ◽  
Magnetic Resonance Spectroscopy ◽  
Data Processing ◽  
Biomedical Research ◽  
Clinical Diagnostics ◽  
Resonance Spectroscopy ◽  
User Friendliness ◽  
Wide Range

AbstractIn vivo magnetic resonance spectroscopy (MRS) is a powerful tool for biomedical research and clinical diagnostics, allowing for non-invasive measurement and analysis of small molecules from living tissues. However, currently available MRS processing and analytical software tools are limited in their potential for in-depth quality management, access to details of the processing stream, and user friendliness. Moreover, available MRS software focuses on selected aspects of MRS such as simulation, signal processing or analysis, necessitating the use of multiple packages and interfacing among them for biomedical applications. The freeware INSPECTOR comprises enhanced MRS data processing, simulation and analytical capabilities in a one-stop-shop solution for a wide range of biomedical research and diagnostic applications. Extensive data handling, quality management and visualization options are built in, enabling the assessment of every step of the processing chain with maximum transparency. The parameters of the processing can be flexibly chosen and tailored for the specific research problem, and extended confidence information is provided with the analysis. The INSPECTOR software stands out in its user-friendly workflow and potential for automation. In addition to convenience, the functionalities of INSPECTOR ensure rigorous and consistent data processing throughout multi-experiment and multi-center studies.

scholarly journals Polarity-active NIR probes with strong two-photon absorption and ultrahigh binding affinity of insulin amyloid fibrils

2021 ◽  
Author(s):  
Li Li ◽  
Zheng Lv ◽  
Zhongwei Man ◽  
Zhenzhen Xu ◽  
YuLing Wei ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Binding Affinity ◽  
Fluorescent Probes ◽  
Amyloid Fibrils ◽  
Photon Absorption ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Medical Diagnostic

Amyloid fibrils are associated with many neurodegenerative diseases. In-situ and in-vivo visualization of amyloid fibrils is important for medical diagnostic and requires fluorescent probes with both excitation and emission wavelengths in...

scholarly journals Insulin amyloid polymorphs: implications for iatrogenic cytotoxicity

RSC Advances ◽  
2020 ◽  
Vol 10 (62) ◽  
pp. 37721-37727 ◽  
Author(s):  
Keisuke Yuzu ◽  
Mikael Lindgren ◽  
Sofie Nyström ◽  
Jun Zhang ◽  
Wakako Mori ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Structural Polymorphism

Structural polymorphism of insulin amyloids in vivo can be recognized using novel amyloid specific fluorescent probes, pFTAA and BTD21.

scholarly journals Biological nanoscale fluorescent probes: From structure and performance to bioimaging

2020 ◽  
Vol 39 (1) ◽  
pp. 209-221
Author(s):  
Jiafeng Wan ◽  
Xiaoyuan Zhang ◽  
Kai Zhang ◽  
Zhiqiang Su
Keyword(s):  
Fluorescent Probes ◽  
Organic Dyes ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
High Sensitivity ◽  
Biological Imaging ◽  
Fluorescent Materials ◽  
And Performance

Abstract In recent years, nanomaterials have attracted lots of attention from researchers due to their unique properties. Nanometer fluorescent materials, such as organic dyes, semiconductor quantum dots (QDs), metal nano-clusters (MNCs), carbon dots (CDs), etc., are widely used in biological imaging due to their high sensitivity, short response time, and excellent accuracy. Nanometer fluorescent probes can not only perform in vitro imaging of organisms but also achieve in vivo imaging. This provides medical staff with great convenience in cancer treatment. Combined with contemporary medical methods, faster and more effective treatment of cancer is achievable. This article explains the response mechanism of three-nanometer fluorescent probes: the principle of induced electron transfer (PET), the principle of fluorescence resonance energy transfer (FRET), and the principle of intramolecular charge transfer (ICT), showing the semiconductor QDs, precious MNCs, and CDs. The excellent performance of the three kinds of nano fluorescent materials in biological imaging is highlighted, and the application of these three kinds of nano fluorescent probes in targeted biological imaging is also introduced. Nanometer fluorescent materials will show their significance in the field of biomedicine.

scholarly journals Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Shangfeng Wang ◽  
Yong Fan ◽  
Dandan Li ◽  
Caixia Sun ◽  
Zuhai Lei ◽  
...  
Keyword(s):  
Ph Sensing ◽  
High Contrast ◽  
Contrast Imaging ◽  
High Contrast Imaging

scholarly journals High-contrast in vivo visualization of microvessels using novel FeCo/GC magnetic nanocrystals

2009 ◽  
Vol 62 (6) ◽  
pp. 1497-1509 ◽  
Author(s):  
Jin Hyung Lee ◽  
Sarah P. Sherlock ◽  
Masahiro Terashima ◽  
Hisanori Kosuge ◽  
Yoriyasu Suzuki ◽  
...  
Keyword(s):  
High Contrast ◽  
Magnetic Nanocrystals
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