scholarly journals Polarity-active NIR probes with strong two-photon absorption and ultrahigh binding affinity of insulin amyloid fibrils

2021 ◽  
Author(s):  
Li Li ◽  
Zheng Lv ◽  
Zhongwei Man ◽  
Zhenzhen Xu ◽  
YuLing Wei ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Binding Affinity ◽  
Fluorescent Probes ◽  
Amyloid Fibrils ◽  
Photon Absorption ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Medical Diagnostic

Amyloid fibrils are associated with many neurodegenerative diseases. In-situ and in-vivo visualization of amyloid fibrils is important for medical diagnostic and requires fluorescent probes with both excitation and emission wavelengths in...

scholarly journals Two-Photon Time-Gated In Vivo Imaging of Dihydrolipoic-Acid-Decorated Gold Nanoclusters

Materials ◽  
2021 ◽  
Vol 14 (24) ◽  
pp. 7744
Author(s):  
Ye Tian ◽  
Ming Wei ◽  
Lijun Wang ◽  
Yuankai Hong ◽  
Dan Luo ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Gold Nanoclusters ◽  
Photon Absorption ◽  
Gold Nanocluster ◽  
Time Resolved ◽  
Dihydrolipoic Acid ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Time Resolved Imaging

Due to the unique advantages of two-photon technology and time-resolved imaging technology in the biomedical field, attention has been paid to them. Gold clusters possess excellent physicochemical properties and low biotoxicity, which make them greatly advantageous in biological imaging, especially for in vivo animal imaging. A gold nanocluster was coupled with dihydrolipoic acid to obtain a functionalized nanoprobe; the material displayed significant features, including a large two-photon absorption cross-section (up to 1.59 × 105 GM) and prolonged fluorescence lifetime (>300 ns). The two-photon and time-resolution techniques were used to perform cell imaging and in vivo imaging.

Designing two-photon fluorescent probes based on the target-induced enhancement of the absorption cross-section

2014 ◽  
Vol 50 (76) ◽  
pp. 11139-11142 ◽  
Author(s):  
Lingyu Zeng ◽  
Shiyu Chen ◽  
Tian Xia ◽  
Cheng Zhong ◽  
Zhihong Liu
Keyword(s):  
Quantum Yield ◽  
Cross Section ◽  
Fluorescent Probes ◽  
Absorption Cross Section ◽  
Photon Absorption ◽  
Probe Design ◽  
Absorption Cross ◽  
Two Photon Absorption ◽  
Two Photon ◽  
New Strategy

We have reported a new strategy for two-photon probe design for the simultaneous target-induced enhancement of the two-photon absorption cross-section and quantum yield.

scholarly journals Rational design of small indolic squaraine dyes with large two-photon absorption cross section

2015 ◽  
Vol 6 (1) ◽  
pp. 761-769 ◽  
Author(s):  
Chun-Lin Sun ◽  
Qing Liao ◽  
Ting Li ◽  
Jun Li ◽  
Jian-Qiao Jiang ◽  
...  
Keyword(s):  
Cross Section ◽  
Rational Design ◽  
Photon Absorption ◽  
Absorption Cross ◽  
Two Photon Absorption ◽  
Squaraine Dyes ◽  
Two Photon ◽  
Bio Imaging

Assisted by theoretical analysis, we designed a small indolic squaraine with δ > 8000 GM at 780 nm, which is ideal for both in vitro and in vivo bio-imaging applications.

Photostable far-red emitting pluronic silicate nanoparticles: perfect blood pool fluorophores for biphotonic in vivo imaging of the leaky tumour vasculature

RSC Advances ◽  
2016 ◽  
Vol 6 (96) ◽  
pp. 94200-94205 ◽  
Author(s):  
Zheng Zheng ◽  
Flavien Caraguel ◽  
Yuan-Yuan Liao ◽  
Chantal Andraud ◽  
Boudewijn van der Sanden ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Blood Pool ◽  
Pluronic F127 ◽  
Photon Absorption ◽  
Absorption Properties ◽  
Two Photon Absorption ◽  
Two Photon Microscopy ◽  
Two Photon ◽  
Tumour Vasculature

A new non-diffusible fluorescent probe for two photon microscopy, comprising a hydrophobic push-pull dye in the apolar core of Pluronic F127–silica nanoparticles, shows intense red emission (Φf 39% at 650 nm) and two-photon absorption properties in the NIR.

scholarly journals Two-photon absorption of polyfluorene aggregates stabilized by insulin amyloid fibrils

RSC Advances ◽  
2015 ◽  
Vol 5 (61) ◽  
pp. 49363-49368 ◽  
Author(s):  
P. Hanczyc ◽  
A. Justyniarski ◽  
D. A. Gedefaw ◽  
M. R. Andersson ◽  
M. Samoc ◽  
...  
Keyword(s):  
Optical Properties ◽  
Amyloid Fibrils ◽  
Photon Absorption ◽  
Two Photon Absorption ◽  
Two Photon

We report on the photophysical and optical properties of a polyfluorene derivative (PFO) and its binding to the amyloid-forming protein insulin.

scholarly journals Red emissive AIE nanodots with high two-photon absorption efficiency at 1040 nm for deep-tissue in vivo imaging

2015 ◽  
Vol 6 (10) ◽  
pp. 3783 ◽  
Author(s):  
Yalun Wang ◽  
Rongrong Hu ◽  
Wang Xi ◽  
Fuhong Cai ◽  
Shaowei Wang ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Absorption Efficiency ◽  
Photon Absorption ◽  
Deep Tissue ◽  
Two Photon Absorption ◽  
Two Photon

Exploring the LDS 821 dye as a potential NIR probe for the two photon imaging of amyloid fibrils

2020 ◽  
Vol 8 (21) ◽  
pp. 6082-6092
Author(s):  
Sony Udayan ◽  
D. R. Sherin ◽  
Samiyappan Vijaykumar ◽  
T. K. Manojkumar ◽  
V. P. N. Nampoori ◽  
...  
Keyword(s):  
Optical Properties ◽  
Nonlinear Optical ◽  
Near Infrared ◽  
Amyloid Fibrils ◽  
Nonlinear Optical Properties ◽  
Photon Absorption ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Large Enhancement ◽  
Near Infrared Dye

Nonlinear optical properties of near infrared dye LDS 821 incorporating lysozyme amyloid fibrils were studied at two wavelengths. The two photon absorption of the dye shows a large enhancement with lysozyme fibrils.

scholarly journals Sensing Performance and Efficiency of Two Energy Transfer-Based Two-Photon Fluorescent Probes for pH

Sensors ◽  
2018 ◽  
Vol 18 (12) ◽  
pp. 4407
Author(s):  
Yujin Zhang ◽  
Wei Hu
Keyword(s):  
Energy Transfer ◽  
Fluorescent Probes ◽  
Energy Transfer Process ◽  
Energy Transfer Efficiency ◽  
Photon Absorption ◽  
Biological Processes ◽  
Two Photon Absorption ◽  
Design And Synthesis ◽  
Two Photon ◽  
Ph Values

The design and synthesis of fluorescent probes for monitoring pH values inside living cells have attracted great attention, due to the important role pH plays in many biological processes. In this study, the optical properties of two different two-photon fluorescent probes for pH are studied. The ratiometric sensing of the probes are theoretically illustrated. Meanwhile, the recognitional mechanisms of the probes are investigated, which shows the energy transfer process when react with H+. Specially, the calculated results demonstrate that Probe1 possesses a higher energy transfer efficiency and a larger two-photon absorption cross-section than Probe2, indicating it to be a preferable pH fluorescent probe. Therefore, the influence of connection between the donor and the acceptor on the sensing performances of the probe is demonstrated. Our results help to understand the experimental observations and provide a theoretical basis to synthesize efficient two-photon fluorescent probes for monitoring pH changes.

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