scholarly journals Synthesis of AIEgen Functionalized Cucurbit[7]uril for Subcellular Bioimaging and Synergistic Photodynamic Therapy and Supramolecular Chemotherapy

2021 ◽  
Author(s):  
Jia Chen ◽  
Shengke Li ◽  
Zeyu Wang ◽  
Yating Pan ◽  
Jianwen Wei ◽  
...  
Keyword(s):  
Optical Properties ◽  
Photodynamic Therapy ◽  
Biomedical Applications ◽  
Aggregation Induced Emission

Aggregation-induced emission (AIE) based fluorophores (AIEgen) have attracted increasing attention for biomedical applications due to their unique optical properties. Here we report an AIE photosensitizer functionalized CB[7], namely AIECB[7], which...

scholarly journals Core-shell Semiconductor Nanocrystals: Effect of Composition, Size, Surface Coatings on their Optical Properties, Toxicity and Pharmacokinetics

2017 ◽  
Vol 23 (3) ◽  
pp. 340-349 ◽  
Author(s):  
Wafa' T. Al-Jamal
Keyword(s):  
Quantum Dots ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Biomedical Applications ◽  
Semiconductor Nanocrystals ◽  
Organic Dye ◽  
Surface Coatings ◽  
Core Shell ◽  
Biomedical Field

Quantum dots are semiconducting nanocrystals that exhibit extraordinary optical properties. QD have shown higher photostability compared to standard organic dye type probes. Therefore, they have been heavily explored in the biomedical field. This review will discuss the different approaches to synthesis, solubilise and functionalise QD. Their main biomedical applications in imaging and photodynamic therapy will be highlighted. Finally, QD biodistribution profile and in vivo toxicity will be discussed.

Advances in luminescent materials with aggregation-induced emission (AIE) properties for biomedical applications

2018 ◽  
Vol 6 (24) ◽  
pp. 4029-4042 ◽  
Author(s):  
Haibo Wang ◽  
Gongyan Liu
Keyword(s):  
Optical Properties ◽  
Species Diversity ◽  
Biomedical Research ◽  
Biomedical Applications ◽  
High Sensitivity ◽  
Luminescent Materials ◽  
Aggregation Induced Emission ◽  
Fluorescent Materials

Fluorescent materials with AIE effect have recently received great attention in biomedical research because of their good optical properties, species diversity and high sensitivity.

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

A mitochondria-targeted dual-functional aggregation-induced emission luminogen for intracellular mitochondrial imaging and photodynamic therapy

2021 ◽  
Vol 9 (4) ◽  
pp. 1232-1236
Author(s):  
Yujie Zhang ◽  
Wendi Huang ◽  
Xueying Tan ◽  
Jinhui Wang ◽  
Yufen Zhao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Aggregation Induced Emission ◽  
Dual Functional

A mitochondria-targeted dual-functional aggregation-induced emission luminogen, TPP-TPEDCH, was rationally designed and developed for intracellular mitochondrial imaging and photodynamic therapy.

Rational design of HA-AuNPs@AIEDs nanoassembly for activatable fluorescence detection of HAase and imaging in tumor cells.

2021 ◽  
Author(s):  
Shenglan Wang ◽  
Chong-Hua Zhang ◽  
Peisheng Zhang ◽  
Shu Chen ◽  
Zhi-ling Song ◽  
...  
Keyword(s):  
Optical Properties ◽  
Tumor Cells ◽  
Fluorescence Detection ◽  
Rational Design ◽  
High Brightness ◽  
Aggregation Induced Emission ◽  
Fluorescence Bioimaging ◽  
In Virtue Of

Aggregation induced emission (AIE) dots have gained broad attention in fluorescence bioimaging and biosensor in virtue of their distinctive optical properties of splendid biocompatibility, high brightness and good photostability. However,...

scholarly journals Organic dots (O-dots) for theranostic applications: preparation and surface engineering

RSC Advances ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 2253-2291
Author(s):  
Amin Shiralizadeh Dezfuli ◽  
Elmira Kohan ◽  
Sepand Tehrani Fateh ◽  
Neda Alimirzaei ◽  
Hamidreza Arzaghi ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Photodynamic Therapy ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Surface Engineering ◽  
Graphene Quantum Dots ◽  
Carbon Quantum Dots ◽  
Cargo Delivery ◽  
Bio Imaging ◽  
Theranostic Applications

Organic dots is a term used to represent materials including graphene quantum dots and carbon quantum dots because they rely on the presence of other atoms (O, H, and N) for their photoluminescence or fluorescence properties. Cargo delivery, bio-imaging, photodynamic therapy and photothermal therapy are major biomedical applications of organic dots.

Sign in / Sign up

Export Citation Format

Share Document