Advances in luminescent materials with aggregation-induced emission (AIE) properties for biomedical applications

2018 ◽  
Vol 6 (24) ◽  
pp. 4029-4042 ◽  
Author(s):  
Haibo Wang ◽  
Gongyan Liu
Keyword(s):  
Optical Properties ◽  
Species Diversity ◽  
Biomedical Research ◽  
Biomedical Applications ◽  
High Sensitivity ◽  
Luminescent Materials ◽  
Aggregation Induced Emission ◽  
Fluorescent Materials

Fluorescent materials with AIE effect have recently received great attention in biomedical research because of their good optical properties, species diversity and high sensitivity.

scholarly journals Luminescent Hydroxyapatite Doped with Rare Earth Elements for Biomedical Applications

Nanomaterials ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 239 ◽  
Author(s):  
Ionela Andreea Neacsu ◽  
Alexandra Elena Stoica ◽  
Bogdan Stefan Vasile ◽  
Ecaterina Andronescu
Keyword(s):  
Rare Earth ◽  
Rare Earth Elements ◽  
Biomedical Applications ◽  
High Efficiency ◽  
Luminescent Materials ◽  
Apatite Structure ◽  
Inorganic Component ◽  
Medical Field ◽  
Fluorescent Materials ◽  
Interesting Area

One new, promising approach in the medical field is represented by hydroxyapatite doped with luminescent materials for biomedical luminescence imaging. The use of hydroxyapatite-based luminescent materials is an interesting area of research because of the attractive characteristics of such materials, which include biodegradability, bioactivity, biocompatibility, osteoconductivity, non-toxicity, and their non-inflammatory nature, as well their accessibility for surface adaptation. It is well known that hydroxyapatite, the predominant inorganic component of bones, serves a substantial role in tissue engineering, drug and gene delivery, and many other biomedical areas. Hydroxyapatite, to the detriment of other host matrices, has attracted substantial attention for its ability to bind to luminescent materials with high efficiency. Its capacity to integrate a large assortment of substitutions for Ca2+, PO43−, and/or OH− ions is attributed to the versatility of its apatite structure. This paper summarizes the most recently developed fluorescent materials based on hydroxyapatite, which use rare earth elements (REEs) as dopants, such as terbium (Tb3+), erbium (Er3+), europium (Eu3+), lanthanum (La3+), or dysprosium (Dy3+), that have been developed in the biomedical field.

scholarly journals Synthesis of AIEgen Functionalized Cucurbit[7]uril for Subcellular Bioimaging and Synergistic Photodynamic Therapy and Supramolecular Chemotherapy

2021 ◽  
Author(s):  
Jia Chen ◽  
Shengke Li ◽  
Zeyu Wang ◽  
Yating Pan ◽  
Jianwen Wei ◽  
...  
Keyword(s):  
Optical Properties ◽  
Photodynamic Therapy ◽  
Biomedical Applications ◽  
Aggregation Induced Emission

Aggregation-induced emission (AIE) based fluorophores (AIEgen) have attracted increasing attention for biomedical applications due to their unique optical properties. Here we report an AIE photosensitizer functionalized CB[7], namely AIECB[7], which...

scholarly journals PHOTONIC CRYSTAL WAVEGUIDE BIOSENSOR

2013 ◽  
Vol 06 (02) ◽  
pp. 1350008 ◽  
Author(s):  
A. A. ZANISHEVSKAYA ◽  
A. V. MALININ ◽  
V. V. TUCHIN ◽  
YU. S. SKIBINA ◽  
I. YU. SILOKHIN
Keyword(s):  
Optical Properties ◽  
Photonic Crystal ◽  
Biomedical Applications ◽  
High Sensitivity ◽  
Optical Systems ◽  
Artificial Sweetener ◽  
Hollow Core ◽  
Photonic Crystal Waveguide ◽  
Industrial Settings

The hollow core photonic crystal waveguide biosensor is designed and described. The biosensor was tested in experiments for artificial sweetener identification in drinks. The photonic crystal waveguide biosensor has a high sensitivity to the optical properties of liquids filling up the hollow core. The compactness, good integration ability to different optical systems and compatibility for use in industrial settings make such biosensor very promising for various biomedical applications.

scholarly journals A Novel Coumarin-Based Fluorescent Probe With Aggregation Induced Emission for Detecting Cn− and Its Applications in Bioimaging

2021 ◽  
Author(s):  
Sha Deng ◽  
Qiao Lei ◽  
Junzhe Cai ◽  
Yuliang Jiang ◽  
Jian Shen
Keyword(s):  
Optical Properties ◽  
Excited State ◽  
High Selectivity ◽  
High Sensitivity ◽  
Intramolecular Proton Transfer ◽  
Living Cells ◽  
Aggregation Induced Emission ◽  
Channel Response ◽  
Dual Channel ◽  
Low Toxicity

Abstract Although cyanogen ion (CN-) plays important role in industry which also bring acute environmental pollution. More serious, trace CN- enters the human body can cause serious consequences and even death. Therefore, it is of great significance to detect trace CN- with high sensitivity. Herein, a novel aggregation-induced emission (AIE) probe C-BH was synthesized based on coumarin matrix. Probe C-BH showed high selectivity and sensitivity toward CN- by dual channel response due to the excited state intramolecular proton transfer (ESIPT). The low detection limit was calculated to be 0.05 µM. Moreover, probe C-BH was successfully used for imaging CN- in living cells and zebrafish due to its low toxicity and excellent optical properties.

Applications of Scanning Microscopy in Biomedical Research

1968 ◽  
Vol 26 ◽  
pp. 354-355
Author(s):  
T. L. Hayes
Keyword(s):  
Information Content ◽  
Biomedical Research ◽  
Biomedical Applications ◽  
Three Dimensional ◽  
Dental Enamel ◽  
Resolving Power ◽  
Whole Mount ◽  
Two Parameters ◽  
Content Information ◽  
Sectioned Tissue

Biomedical applications of the scanning electron microscope (SEM) have increased in number quite rapidly over the last several years. Studies have been made of cells, whole mount tissue, sectioned tissue, particles, human chromosomes, microorganisms, dental enamel and skeletal material. Many of the advantages of using this instrument for such investigations come from its ability to produce images that are high in information content. Information about the chemical make-up of the specimen, its electrical properties and its three dimensional architecture all may be represented in such images. Since the biological system is distinctive in its chemistry and often spatially scaled to the resolving power of the SEM, these images are particularly useful in biomedical research.In any form of microscopy there are two parameters that together determine the usefulness of the image. One parameter is the size of the volume being studied or resolving power of the instrument and the other is the amount of information about this volume that is displayed in the image. Both parameters are important in describing the performance of a microscope. The light microscope image, for example, is rich in information content (chemical, spatial, living specimen, etc.) but is very limited in resolving power.

Graphene and Graphene-Based Materials in Biomedical Applications

2019 ◽  
Vol 26 (38) ◽  
pp. 6834-6850 ◽  
Author(s):  
Mohammad Omaish Ansari ◽  
Kalamegam Gauthaman ◽  
Abdurahman Essa ◽  
Sidi A. Bencherif ◽  
Adnan Memic
Keyword(s):  
Tissue Engineering ◽  
Thermal Properties ◽  
Gene Delivery ◽  
Regenerative Medicine ◽  
Biomedical Research ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Two Dimensional ◽  
Drug And Gene Delivery ◽  
Biomedical Fields

: Nanobiotechnology has huge potential in the field of regenerative medicine. One of the main drivers has been the development of novel nanomaterials. One developing class of materials is graphene and its derivatives recognized for their novel properties present on the nanoscale. In particular, graphene and graphene-based nanomaterials have been shown to have excellent electrical, mechanical, optical and thermal properties. Due to these unique properties coupled with the ability to tune their biocompatibility, these nanomaterials have been propelled for various applications. Most recently, these two-dimensional nanomaterials have been widely recognized for their utility in biomedical research. In this review, a brief overview of the strategies to synthesize graphene and its derivatives are discussed. Next, the biocompatibility profile of these nanomaterials as a precursor to their biomedical application is reviewed. Finally, recent applications of graphene-based nanomaterials in various biomedical fields including tissue engineering, drug and gene delivery, biosensing and bioimaging as well as other biorelated studies are highlighted.

Rational design of HA-AuNPs@AIEDs nanoassembly for activatable fluorescence detection of HAase and imaging in tumor cells.

2021 ◽  
Author(s):  
Shenglan Wang ◽  
Chong-Hua Zhang ◽  
Peisheng Zhang ◽  
Shu Chen ◽  
Zhi-ling Song ◽  
...  
Keyword(s):  
Optical Properties ◽  
Tumor Cells ◽  
Fluorescence Detection ◽  
Rational Design ◽  
High Brightness ◽  
Aggregation Induced Emission ◽  
Fluorescence Bioimaging ◽  
In Virtue Of

Aggregation induced emission (AIE) dots have gained broad attention in fluorescence bioimaging and biosensor in virtue of their distinctive optical properties of splendid biocompatibility, high brightness and good photostability. However,...

scholarly journals Interfacing aptamers, nanoparticles and graphene in a hierarchical structure for highly selective detection of biomolecules in OECT devices

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Carlotta Peruzzi ◽  
Silvia Battistoni ◽  
Daniela Montesarchio ◽  
Matteo Cocuzza ◽  
Simone Luigi Marasso ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Au Nanoparticles ◽  
Limit Of Detection ◽  
High Sensitivity ◽  
Minimal Invasiveness ◽  
Hierarchic Structure ◽  
Final Response ◽  
Detection Of Biomolecules ◽  
Good Signal ◽  
Detection Of Biomarkers

AbstractIn several biomedical applications, the detection of biomarkers demands high sensitivity, selectivity and easy-to-use devices. Organic electrochemical transistors (OECTs) represent a promising class of devices combining a minimal invasiveness and good signal transduction. However, OECTs lack of intrinsic selectivity that should be implemented by specific approaches to make them well suitable for biomedical applications. Here, we report on a biosensor in which selectivity and a high sensitivity are achieved by interfacing, in an OECT architecture, a novel gate electrode based on aptamers, Au nanoparticles and graphene hierarchically organized to optimize the final response. The fabricated biosensor performs state of the art limit of detection monitoring biomolecules, such as thrombin-with a limit of detection in the picomolar range (≤ 5 pM) and a very good selectivity even in presence of supraphysiological concentrations of Bovine Serum Albumin (BSA-1mM). These accomplishments are the final result of the gate hierarchic structure that reduces sterich indrance that could contrast the recognition events and minimizes false positive, because of the low affinity of graphene towards the physiological environment. Since our approach can be easily applied to a large variety of different biomarkers, we envisage a relevant potential for a large series of different biomedical applications.

scholarly journals Biological nanoscale fluorescent probes: From structure and performance to bioimaging

2020 ◽  
Vol 39 (1) ◽  
pp. 209-221
Author(s):  
Jiafeng Wan ◽  
Xiaoyuan Zhang ◽  
Kai Zhang ◽  
Zhiqiang Su
Keyword(s):  
Fluorescent Probes ◽  
Organic Dyes ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
High Sensitivity ◽  
Biological Imaging ◽  
Fluorescent Materials ◽  
And Performance

Abstract In recent years, nanomaterials have attracted lots of attention from researchers due to their unique properties. Nanometer fluorescent materials, such as organic dyes, semiconductor quantum dots (QDs), metal nano-clusters (MNCs), carbon dots (CDs), etc., are widely used in biological imaging due to their high sensitivity, short response time, and excellent accuracy. Nanometer fluorescent probes can not only perform in vitro imaging of organisms but also achieve in vivo imaging. This provides medical staff with great convenience in cancer treatment. Combined with contemporary medical methods, faster and more effective treatment of cancer is achievable. This article explains the response mechanism of three-nanometer fluorescent probes: the principle of induced electron transfer (PET), the principle of fluorescence resonance energy transfer (FRET), and the principle of intramolecular charge transfer (ICT), showing the semiconductor QDs, precious MNCs, and CDs. The excellent performance of the three kinds of nano fluorescent materials in biological imaging is highlighted, and the application of these three kinds of nano fluorescent probes in targeted biological imaging is also introduced. Nanometer fluorescent materials will show their significance in the field of biomedicine.

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