scholarly journals Hydrophilic modification of SLA 3D printed droplet generators by photochemical grafting

RSC Advances ◽  
2021 ◽  
Vol 11 (35) ◽  
pp. 21745-21753
Author(s):  
Tristan W. Bacha ◽  
Dylan C. Manuguerra ◽  
Robert A. Marano ◽  
Joseph F. Stanzione
Keyword(s):  
Microfluidic Devices ◽  
Polystyrene Microspheres ◽  
Hydrophilic Modification ◽  
3D Printed ◽  
Photochemical Grafting ◽  
Droplet Generators

A versatile method of manufacturing and directly modifying the surfaces of 3D printed microfluidic devices was developed. The device functionality was demonstrated by producing o/w emulsions that yielded polystyrene microspheres.

Automated calibration of 3D-printed microfluidic devices based on computer vision

2021 ◽  
Vol 15 (2) ◽  
pp. 024102
Author(s):  
Junchao Wang ◽  
Kaicong Liang ◽  
Naiyin Zhang ◽  
Hailong Yao ◽  
Tsung-Yi Ho ◽  
...  
Keyword(s):  
Computer Vision ◽  
Microfluidic Devices ◽  
Automated Calibration ◽  
3D Printed

scholarly journals Rapid Production of PDMS Microdevices for Electrodriven Separations and Microfluidics by 3D-Printed Scaffold Removal

Separations ◽  
2021 ◽  
Vol 8 (5) ◽  
pp. 67
Author(s):  
Alena Šustková ◽  
Klára Konderlová ◽  
Ester Drastíková ◽  
Stefan Sützl ◽  
Lenka Hárendarčíková ◽  
...  
Keyword(s):  
Organic Dyes ◽  
Microfluidic Devices ◽  
Proof Of Concept ◽  
Magnetic Microparticles ◽  
Mechanical Removal ◽  
Glass Slides ◽  
Rapid Production ◽  
3D Printed

In our work, we produced PDMS-based microfluidic devices by mechanical removal of 3D-printed scaffolds inserted in PDMS. Two setups leading to the fabrication of monolithic PDMS-based microdevices and bonded (or stamped) PDMS-based microdevices were designed. In the monolithic devices, the 3D-printed scaffolds were fully inserted in the PDMS and then carefully removed. The bonded devices were produced by forming imprints of the 3D-printed scaffolds in PDMS, followed by bonding the PDMS parts to glass slides. All these microfluidic devices were then successfully employed in three proof-of-concept applications: capture of magnetic microparticles, formation of droplets, and isotachophoresis separation of model organic dyes.

scholarly journals 3D printed microfluidic devices with immunoaffinity monoliths for extraction of preterm birth biomarkers

2018 ◽  
Vol 411 (21) ◽  
pp. 5405-5413 ◽  
Author(s):  
Ellen K. Parker ◽  
Anna V. Nielsen ◽  
Michael J. Beauchamp ◽  
Haifa M. Almughamsi ◽  
Jacob B. Nielsen ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Microfluidic Devices ◽  
3D Printed

3D printed microfluidic devices and applications

2021 ◽  
pp. 659-679
Author(s):  
Sui Ching Phung ◽  
Qingfu Zhu ◽  
Kimberly Plevniak ◽  
Mei He
Keyword(s):  
Microfluidic Devices ◽  
3D Printed

scholarly journals Microfluidic droplet generation based on non-embedded co-flow-focusing using 3D printed nozzle

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Adrien Dewandre ◽  
Javier Rivero-Rodriguez ◽  
Youen Vitry ◽  
Benjamin Sobac ◽  
Benoit Scheid
Keyword(s):  
Stokes Equations ◽  
Axisymmetric Flow ◽  
Droplet Generation ◽  
Droplet Radius ◽  
Planar Geometry ◽  
Flow Focusing ◽  
Glass Capillary ◽  
New Device ◽  
3D Printed ◽  
Droplet Generators

AbstractMost commercial microfluidic droplet generators rely on the planar flow-focusing configuration implemented in polymer or glass chips. The planar geometry, however, suffers from many limitations and drawbacks, such as the need of specific coatings or the use of dedicated surfactants, depending on the fluids in play. On the contrary, and thanks to their axisymmetric geometry, glass capillary-based droplet generators are a priori not fluid-dependent. Nevertheless, they have never reached the market because their assembly requires fastidious and not scalable fabrication techniques. Here we present a new device, called Raydrop, based on the alignment of two capillaries immersed in a pressurized chamber containing the continuous phase. The dispersed phase exits one of the capillaries through a 3D-printed nozzle placed in front of the extraction capillary for collecting the droplets. This non-embedded implementation of an axisymmetric flow-focusing is referred to non-embedded co-flow-focusing configuration. Experimental results demonstrate the universality of the device in terms of the variety of fluids that can be emulsified, as well as the range of droplet radii that can be obtained, without neither the need of surfactant nor coating. Additionally, numerical computations of the Navier-Stokes equations based on the quasi-steadiness assumption allow to provide an explanation to the underlying mechanism behind the drop formation and the mechanism of the dripping to jetting transition. Excellent predictions were also obtained for the droplet radius, as well as for the dripping-jetting transition, when varying the geometrical and fluid parameters, showing the ability of this configuration to enventually enhance the dripping regime. The monodispersity ensured by the dripping regime, the robustness of the fabrication technique, the optimization capabilities from the numerical modelling and the universality of the configuration confer to the Raydrop technology a very high potential in the race towards high-throughput droplet generation processes.

Integration of optical manipulation in 3D printed microfluidic devices (Conference Presentation)

2020 ◽  
Author(s):  
Haoran Wang ◽  
Anton Enders ◽  
Alexander Heisterkamp ◽  
Janina Bahnemann ◽  
Maria Leilani Torres-Mapa
Keyword(s):  
Microfluidic Devices ◽  
Optical Manipulation ◽  
3D Printed

scholarly journals 3D Printed Microfluidics

2020 ◽  
Vol 13 (1) ◽  
pp. 45-65 ◽  
Author(s):  
Anna V. Nielsen ◽  
Michael J. Beauchamp ◽  
Gregory P. Nordin ◽  
Adam T. Woolley
Keyword(s):  
3D Printing ◽  
Early Stage ◽  
Three Dimensional ◽  
Microfluidic Devices ◽  
Fabrication Method ◽  
Size Scale ◽  
Additional Work ◽  
Fluidic Devices ◽  
3D Printed ◽  
Microfabrication Techniques

Traditional microfabrication techniques suffer from several disadvantages, including the inability to create truly three-dimensional (3D) architectures, expensive and time-consuming processes when changing device designs, and difficulty in transitioning from prototyping fabrication to bulk manufacturing. 3D printing is an emerging technique that could overcome these disadvantages. While most 3D printed fluidic devices and features to date have been on the millifluidic size scale, some truly microfluidic devices have been shown. Currently, stereolithography is the most promising approach for routine creation of microfluidic structures, but several approaches under development also have potential. Microfluidic 3D printing is still in an early stage, similar to where polydimethylsiloxane was two decades ago. With additional work to advance printer hardware and software control, expand and improve resin and printing material selections, and realize additional applications for 3D printed devices, we foresee 3D printing becoming the dominant microfluidic fabrication method.

scholarly journals Characterization of Soft Tooling Photopolymers and Processes for Micromixing Devices with Variable Cross-Section

Micromachines ◽  
2020 ◽  
Vol 11 (11) ◽  
pp. 970
Author(s):  
J. Israel Martínez-López ◽  
Héctor Andrés Betancourt Cervantes ◽  
Luis Donaldo Cuevas Iturbe ◽  
Elisa Vázquez ◽  
Edisson A. Naula ◽  
...  
Keyword(s):  
Flow Regime ◽  
Cross Section ◽  
Cross Sections ◽  
Microfluidic Devices ◽  
Variable Cross Section ◽  
Variable Cross ◽  
Multiple Cross ◽  
3D Printed

In this paper, we characterized an assortment of photopolymers and stereolithography processes to produce 3D-printed molds and polydimethylsiloxane (PDMS) castings of micromixing devices. Once materials and processes were screened, the validation of the soft tooling approach in microfluidic devices was carried out through a case study. An asymmetric split-and-recombine device with different cross-sections was manufactured and tested under different regime conditions (10 < Re < 70). Mixing performances between 3% and 96% were obtained depending on the flow regime and the pitch-to-depth ratio. The study shows that 3D-printed soft tooling can provide other benefits such as multiple cross-sections and other potential layouts on a single mold.

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