scholarly journals Dissolving microneedles delivering cancer cell membrane coated nanoparticles for cancer immunotherapy

RSC Advances ◽  
2021 ◽  
Vol 11 (17) ◽  
pp. 10393-10399
Author(s):  
Wonchan Park ◽  
Keum Yong Seong ◽  
Hye Hyeon Han ◽  
Seung Yun Yang ◽  
Sei Kwang Hahn
Keyword(s):  
Immune System ◽  
Cell Membrane ◽  
Cancer Immunotherapy ◽  
Cancer Cell ◽  
Transdermal Delivery ◽  
Toll Like Receptor ◽  
Tumor Vaccines ◽  
Tlr Agonists ◽  
Coated Nanoparticles ◽  
Dissolving Microneedles

Recently, a variety of tumor vaccines and immune system stimulators such as toll-like receptor (TLR) agonists have been widely investigated for cancer immunotherapy via transdermal delivery.

The Next Generation of Pattern Recognition Receptor Agonists: Improving Response Rates in Cancer Immunotherapy

2020 ◽  
Vol 27 (34) ◽  
pp. 5654-5674 ◽  
Author(s):  
Daniel H. O’ Donovan ◽  
Yumeng Mao ◽  
Deanna A. Mele
Keyword(s):  
Pattern Recognition ◽  
Immune System ◽  
Cancer Immunotherapy ◽  
Anticancer Agents ◽  
Adaptive Immune System ◽  
Antitumor Effects ◽  
Tlr Agonists ◽  
Recent Success ◽  
Promising Target ◽  
Tumor Types

The recent success of checkpoint blocking antibodies has sparked a revolution in cancer immunotherapy. Checkpoint inhibition activates the adaptive immune system leading to durable responses across a range of tumor types, although this response is limited to patient populations with pre-existing tumor-infiltrating T cells. Strategies to stimulate the immune system to prime an antitumor response are of intense interest and several groups are now working to develop agents to activate the Pattern Recognition Receptors (PRRs), proteins which detect pathogenic and damageassociated molecules and respond by activating the innate immune response. Although early efforts focused on the Toll-like Receptor (TLR) family of membrane-bound PRRs, TLR activation has been associated with both pro- and antitumor effects. Nonetheless, TLR agonists have been deployed as potential anticancer agents in a range of clinical trials. More recently, the cytosolic PRR Stimulator of IFN Genes (STING) has attracted attention as another promising target for anticancer drug development, with early clinical data beginning to emerge. Besides STING, several other cytosolic PRR targets have likewise captured the interest of the drug discovery community, including the RIG-Ilike Receptors (RLRs) and NOD-like Receptors (NLRs). In this review, we describe the outlook for activators of PRRs as anticancer therapeutic agents and contrast the earlier generation of TLR agonists with the emerging focus on cytosolic PRR activators, both as single agents and in combination with other cancer immunotherapies.

Personalized Nanovaccine Coated with Calcinetin-Expressed Cancer Cell Membrane Antigen for Cancer Immunotherapy

Nano Letters ◽  
2021 ◽  
Author(s):  
Xiang Xiong ◽  
Jingya Zhao ◽  
Jingmei Pan ◽  
Chunping Liu ◽  
Xing Guo ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Immunotherapy ◽  
Cancer Cell ◽  
Cell Membrane Antigen

Cancer-Cell-Membrane-Coated Nanoparticles with a Yolk–Shell Structure Augment Cancer Chemotherapy

Nano Letters ◽  
2019 ◽  
Vol 20 (2) ◽  
pp. 936-946 ◽  
Author(s):  
Di Nie ◽  
Zhuo Dai ◽  
Jialin Li ◽  
Yiwei Yang ◽  
Ziyue Xi ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Cancer Chemotherapy ◽  
Shell Structure ◽  
Coated Nanoparticles

Cell membrane and intracellular expression of toll-like receptor 9 (TLR9) in colorectal cancer and breast cancer cell-lines

2017 ◽  
Vol 18 (4) ◽  
pp. 375-380 ◽  
Author(s):  
Shadab Shahriari ◽  
Somayeh Rezaeifard ◽  
Hamid Reza Moghimi ◽  
Mohammad Reza Khorramizadeh ◽  
Zahra Faghih
Keyword(s):  
Breast Cancer ◽  
Colorectal Cancer ◽  
Cell Membrane ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Toll Like Receptor ◽  
Intracellular Expression

Multistaged Nanovaccines Based on Porous Silicon@Acetalated Dextran@Cancer Cell Membrane for Cancer Immunotherapy

2016 ◽  
Vol 29 (7) ◽  
pp. 1603239 ◽  
Author(s):  
Flavia Fontana ◽  
Mohammad-Ali Shahbazi ◽  
Dongfei Liu ◽  
Hongbo Zhang ◽  
Ermei Mäkilä ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Cell Membrane ◽  
Cancer Immunotherapy ◽  
Cancer Cell

Cell membrane-coated nanoparticles as peroxidase mimetics for cancer cell targeted detection and therapy

Talanta ◽  
2021 ◽  
pp. 123071
Author(s):  
Meiling Lian ◽  
Shuaibin Shao ◽  
Meihan Liu ◽  
Yuqing Shi ◽  
Haijun Zhang ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Coated Nanoparticles ◽  
Targeted Detection

scholarly journals Cancer Cell Membrane‐Coated Nanoparticles for Personalized Therapy in Patient‐Derived Xenograft Models

2019 ◽  
Vol 29 (51) ◽  
pp. 1905671 ◽  
Author(s):  
Lang Rao ◽  
Guang‐Tao Yu ◽  
Qian‐Fang Meng ◽  
Lin‐Lin Bu ◽  
Rui Tian ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Personalized Therapy ◽  
Coated Nanoparticles ◽  
Patient Derived Xenograft ◽  
Xenograft Models

scholarly journals Engineering Therapeutic Strategies in Cancer Immunotherapy via Exogenous Delivery of Toll-like Receptor Agonists

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1374
Author(s):  
Sehwan Jeong ◽  
Yunyoung Choi ◽  
Kyobum Kim
Keyword(s):  
T Cells ◽  
Immune Responses ◽  
Cancer Immunotherapy ◽  
Cell Activation ◽  
The Body ◽  
Toll Like Receptor ◽  
Tlr Agonists ◽  
Cytokines And Chemokines ◽  
Adaptive Immune Cells ◽  
Delivery Strategies

As a currently spotlighted method for cancer treatment, cancer immunotherapy has made a lot of progress in recent years. Among tremendous cancer immunotherapy boosters available nowadays, Toll-like receptor (TLR) agonists were specifically selected, because of their effective activation of innate and adaptive immune cells, such as dendritic cells (DCs), T cells, and macrophages. TLR agonists can activate signaling pathways of DCs to express CD80 and CD86 molecules, and secrete various cytokines and chemokines. The maturation of DCs stimulates naïve T cells to differentiate into functional cells, and induces B cell activation. Although TLR agonists have anti-tumor ability by activating the immune system of the host, their drawbacks, which include poor efficiency and remarkably short retention time in the body, must be overcome. In this review, we classify and summarize the recently reported delivery strategies using (1) exogenous TLR agonists to maintain the biological and physiological signaling activities of cargo agonists, (2) usage of multiple TLR agonists for synergistic immune responses, and (3) co-delivery using the combination with other immunomodulators or stimulants. In contrast to naked TLR agonists, these exogenous TLR delivery strategies successfully facilitated immune responses and subsequently mediated anti-tumor efficacy.

scholarly journals Lipid composition of the cancer cell membrane

2020 ◽  
Vol 52 (5) ◽  
pp. 321-342 ◽  
Author(s):  
Wojciech Szlasa ◽  
Iga Zendran ◽  
Aleksandra Zalesińska ◽  
Mounir Tarek ◽  
Julita Kulbacka
Keyword(s):  
Immune System ◽  
Cell Membrane ◽  
Cancer Cell ◽  
Cell Membranes ◽  
Energetic Material ◽  
Theoretical Data ◽  
Cholesterol Content ◽  
System Response ◽  
Membrane Composition ◽  
Immune System Response

Abstract Cancer cell possesses numerous adaptations to resist the immune system response and chemotherapy. One of the most significant properties of the neoplastic cells is the altered lipid metabolism, and consequently, the abnormal cell membrane composition. Like in the case of phosphatidylcholine, these changes result in the modulation of certain enzymes and accumulation of energetic material, which could be used for a higher proliferation rate. The changes are so prominent, that some lipids, such as phosphatidylserines, could even be considered as the cancer biomarkers. Additionally, some changes of biophysical properties of cell membranes lead to the higher resistance to chemotherapy, and finally to the disturbances in signalling pathways. Namely, the increased levels of certain lipids, like for instance phosphatidylserine, lead to the attenuation of the immune system response. Also, changes in lipid saturation prevent the cells from demanding conditions of the microenvironment. Particularly interesting is the significance of cell membrane cholesterol content in the modulation of metastasis. This review paper discusses the roles of each lipid type in cancer physiology. The review combined theoretical data with clinical studies to show novel therapeutic options concerning the modulation of cell membranes in oncology.

scholarly journals Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery

Nano Letters ◽  
2014 ◽  
Vol 14 (4) ◽  
pp. 2181-2188 ◽  
Author(s):  
Ronnie H. Fang ◽  
Che-Ming J. Hu ◽  
Brian T. Luk ◽  
Weiwei Gao ◽  
Jonathan A. Copp ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Membrane ◽  
Cancer Cell ◽  
Coated Nanoparticles
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