scholarly journals Cancer Cell Membrane‐Coated Nanoparticles for Personalized Therapy in Patient‐Derived Xenograft Models

2019 ◽  
Vol 29 (51) ◽  
pp. 1905671 ◽  
Author(s):  
Lang Rao ◽  
Guang‐Tao Yu ◽  
Qian‐Fang Meng ◽  
Lin‐Lin Bu ◽  
Rui Tian ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Personalized Therapy ◽  
Coated Nanoparticles ◽  
Patient Derived Xenograft ◽  
Xenograft Models

Cancer-Cell-Membrane-Coated Nanoparticles with a Yolk–Shell Structure Augment Cancer Chemotherapy

Nano Letters ◽  
2019 ◽  
Vol 20 (2) ◽  
pp. 936-946 ◽  
Author(s):  
Di Nie ◽  
Zhuo Dai ◽  
Jialin Li ◽  
Yiwei Yang ◽  
Ziyue Xi ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Cancer Chemotherapy ◽  
Shell Structure ◽  
Coated Nanoparticles

scholarly journals Evaluation of TAK-264, an Antibody-Drug Conjugate in Pancreatic Cancer Cell Lines and Patient-Derived Xenograft Models

2018 ◽  
Vol 5 (1) ◽  
pp. 42-49 ◽  
Author(s):  
Anna R. Schreiber ◽  
Anna Nguyen ◽  
Stacey M. Bagby ◽  
John J. Arcaroli ◽  
Betelehem W. Yacob ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Lines ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Patient Derived Xenograft ◽  
Xenograft Models ◽  
Antibody Drug

Cell membrane-coated nanoparticles as peroxidase mimetics for cancer cell targeted detection and therapy

Talanta ◽  
2021 ◽  
pp. 123071
Author(s):  
Meiling Lian ◽  
Shuaibin Shao ◽  
Meihan Liu ◽  
Yuqing Shi ◽  
Haijun Zhang ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Coated Nanoparticles ◽  
Targeted Detection

scholarly journals Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery

Nano Letters ◽  
2014 ◽  
Vol 14 (4) ◽  
pp. 2181-2188 ◽  
Author(s):  
Ronnie H. Fang ◽  
Che-Ming J. Hu ◽  
Brian T. Luk ◽  
Weiwei Gao ◽  
Jonathan A. Copp ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Membrane ◽  
Cancer Cell ◽  
Coated Nanoparticles

scholarly journals B-Cell Lymphoma Patient-Derived Xenograft Models Enable Drug Discovery and Are a Platform for Personalized Therapy

2017 ◽  
Vol 23 (15) ◽  
pp. 4212-4223 ◽  
Author(s):  
Leo Zhang ◽  
Krystle Nomie ◽  
Hui Zhang ◽  
Taylor Bell ◽  
Lan Pham ◽  
...  
Keyword(s):  
Drug Discovery ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Personalized Therapy ◽  
Lymphoma Patient ◽  
Patient Derived Xenograft ◽  
Xenograft Models

scholarly journals Dissolving microneedles delivering cancer cell membrane coated nanoparticles for cancer immunotherapy

RSC Advances ◽  
2021 ◽  
Vol 11 (17) ◽  
pp. 10393-10399
Author(s):  
Wonchan Park ◽  
Keum Yong Seong ◽  
Hye Hyeon Han ◽  
Seung Yun Yang ◽  
Sei Kwang Hahn
Keyword(s):  
Immune System ◽  
Cell Membrane ◽  
Cancer Immunotherapy ◽  
Cancer Cell ◽  
Transdermal Delivery ◽  
Toll Like Receptor ◽  
Tumor Vaccines ◽  
Tlr Agonists ◽  
Coated Nanoparticles ◽  
Dissolving Microneedles

Recently, a variety of tumor vaccines and immune system stimulators such as toll-like receptor (TLR) agonists have been widely investigated for cancer immunotherapy via transdermal delivery.

scholarly journals Cancer Cell Membrane-Coated Nanoparticles for Cancer Management

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1836 ◽  
Author(s):  
Jenna C. Harris ◽  
Mackenzie A. Scully ◽  
Emily S. Day
Keyword(s):  
Cell Membrane ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Treatment Success ◽  
Cancer Therapies ◽  
Clinical Implementation ◽  
Cancer Management ◽  
Coated Nanoparticles ◽  
Self Recognition ◽  
Natural Cell

Cancer is a global health problem in need of transformative treatment solutions for improved patient outcomes. Many conventional treatments prove ineffective and produce undesirable side effects because they are incapable of targeting only cancer cells within tumors and metastases post administration. There is a desperate need for targeted therapies that can maximize treatment success and minimize toxicity. Nanoparticles (NPs) with tunable physicochemical properties have potential to meet the need for high precision cancer therapies. At the forefront of nanomedicine is biomimetic nanotechnology, which hides NPs from the immune system and provides superior targeting capabilities by cloaking NPs in cell-derived membranes. Cancer cell membranes expressing “markers of self” and “self-recognition molecules” can be removed from cancer cells and wrapped around a variety of NPs, providing homotypic targeting and circumventing the challenge of synthetically replicating natural cell surfaces. Compared to unwrapped NPs, cancer cell membrane-wrapped NPs (CCNPs) provide reduced accumulation in healthy tissues and higher accumulation in tumors and metastases. The unique biointerfacing capabilities of CCNPs enable their use as targeted nanovehicles for enhanced drug delivery, localized phototherapy, intensified imaging, or more potent immunotherapy. This review summarizes the state-of-the-art in CCNP technology and provides insight to the path forward for clinical implementation.

scholarly journals Biomimetic Upconversion Nanoparticles and Gold Nanoparticles for Novel Simultaneous Dual-Modal Imaging-Guided Photothermal Therapy of Cancer

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3136 ◽  
Author(s):  
Ruliang Wang ◽  
Han Yang ◽  
Rongxin Fu ◽  
Ya Su ◽  
Xue Lin ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Imaging System ◽  
Imaging Systems ◽  
Coated Nanoparticles ◽  
Cancer Theranostics

Multimodal imaging-guided near-infrared (NIR) photothermal therapy (PTT) is an interesting and promising cancer theranostic method. However, most of the multimodal imaging systems provide structural and functional information used for imaging guidance separately by directly combining independent imaging systems with different detectors, and many problems arise when trying to fuse different modal images that are serially taken by inviting extra markers or image fusion algorithms. Further, most imaging and therapeutic agents passively target tumors through the enhanced permeability and retention (EPR) effect, which leads to low utilization efficiency. To address these problems and systematically improve the performance of the imaging-guided PTT methodology, we report a novel simultaneous dual-modal imaging system combined with cancer cell membrane-coated nanoparticles as a platform for PTT-based cancer theranostics. A novel detector with the ability to detect both high-energy X-ray and low-energy visible light at the same time, as well as a dual-modal imaging system based on the detector, was developed for simultaneous dual-modal imaging. Cancer cell membrane-coated upconversion nanoparticles (CC-UCNPs) and gold nanoparticles (CC-AuNPs) with the capacity for immune evasion and active tumor targeting were engineered for highly specific imaging and high-efficiency PTT therapy. In vitro and in vivo evaluation of macrophage escape and active homologous tumor targeting were performed. Cancer cell membrane-coated nanoparticles (CC-NPs) displayed excellent immune evasion ability, longer blood circulation time, and higher tumor targeting specificity compared to normal PEGylated nanoparticles, which led to highly specific upconversion luminescence (UCL) imaging and PTT-based anti-tumor efficacy. The anti-cancer efficacy of the dual-modal imaging-guided PTT was also evaluated both in vitro and in vivo. Dual-modal imaging yielded precise anatomical and functional information for the PTT process, and complete tumor ablation was achieved with CC-AuNPs. Our biomimetic UCNP/AuNP and novel simultaneous dual-modal imaging combination could be a promising platform and methodology for cancer theranostics.

Sign in / Sign up

Export Citation Format

Share Document