Gold Nanoclusters Based Nanocomposites for Combinatorial Antibacterial Therapy on Biofilm Forming Pathogens

2022 ◽  
Author(s):  
Genji Srinivasulu Yuvasri ◽  
Anbu Mozhi Thamizhchelvan ◽  
Nirmal Goswami ◽  
Qiaofeng Yao ◽  
Jianping Xie
Keyword(s):  
Photodynamic Therapy ◽  
Antibacterial Therapy ◽  
Gold Nanoclusters ◽  
Bacterial Biofilm ◽  
Antimicrobial Photodynamic Therapy ◽  
Drug Resistant ◽  
Limited Capacity

Nanomaterial-based antimicrobial photodynamic therapy (aPDT) is a promising approach for the eradication of drug-resistant bacterial biofilm. However, the intrinsic cytotoxicity of the commonly used nanomaterials together with their limited capacity...

scholarly journals Photodynamic Therapy in Orthodontics: A Literature Review

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 720
Author(s):  
Marcin Olek ◽  
Agnieszka Machorowska-Pieniążek ◽  
Wojciech Stós ◽  
Janusz Kalukin ◽  
Dorota Bartusik-Aebisher ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Literature Review ◽  
Periodontal Diseases ◽  
Bacterial Biofilm ◽  
White Spot ◽  
Alternative Methods ◽  
Gingival Hyperplasia ◽  
Antimicrobial Photodynamic Therapy ◽  
White Spot Lesions ◽  
Ultrasonic Scaler

Treatment of malocclusions using fixed orthodontic appliances makes it difficult for patients to perform hygiene procedures. Insufficient removal of bacterial biofilm can cause enamel demineralization, manifesting by visible white spot lesions or periodontal diseases, such as gingivitis periodontitis or gingival hyperplasia. The classic methods of preventing the above problems include, in addition to proper hygiene, ultrasonic scaling, periodontal debridement, and oral rinses based on chlorhexidine. New alternative methods of reducing plaque around brackets are being developed. There is a growing interest among researchers in the possibility of using photodynamic therapy in orthodontics. A literature search for articles corresponding to the topic of this review was performed using the PubMed and Scopus databases and the following keywords: ‘photodynamic therapy’, ‘orthodontics’, and ‘photosensitizer(s)’. Based on the literature review, two main directions of research can be distinguished: clinical research on the use of photodynamic therapy in the prevention of white spot lesions and periodontal diseases, and ex vivo research using a modified orthodontic adhesive by adding photosensitizers to them. Methylene blue is the most frequently used photosensitizer in clinical trials. The effectiveness of antimicrobial photodynamic therapy is mainly compared to the ultrasonic scaler as a single therapy or as an adjunct to the ultrasonic scaler. In their conclusions, the researchers most often emphasize the effectiveness of antimicrobial photodynamic therapy in reducing microbial levels in patients treated with fixed appliances and the possibility of using it as an alternative to routine procedures aimed at maintaining a healthy periodontium. The authors suggest further research on the use of photodynamic therapy to prove the validity of this method in orthodontics. It should also not be forgotten that proper hygiene is the basis for maintaining oral cavity health, and its neglect is a contraindication to orthodontic treatment.

Antimicrobial Photodynamic Therapy on Drug-resistant Pseudomonas aeruginosa-induced Infection. An In Vivo Study†

2012 ◽  
Vol 88 (3) ◽  
pp. 590-595 ◽  
Author(s):  
Maria C. E. Hashimoto ◽  
Renato A. Prates ◽  
Ilka T. Kato ◽  
Silvia C. Núñez ◽  
Lília C. Courrol ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Photodynamic Therapy ◽  
In Vivo Study ◽  
Antimicrobial Photodynamic Therapy ◽  
Drug Resistant

scholarly journals Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy

2021 ◽  
Vol 22 (12) ◽  
pp. 6392
Author(s):  
Nikita Suvorov ◽  
Viktor Pogorilyy ◽  
Ekaterina Diachkova ◽  
Yuri Vasil’ev ◽  
Andrey Mironov ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Heterocyclic Compounds ◽  
Resistant Bacteria ◽  
Antimicrobial Photodynamic Therapy ◽  
Drug Resistant ◽  
Oxygen Species ◽  
Major Research ◽  
Drug Resistant Bacteria ◽  
Research Challenge ◽  
Derivatives Of

The rapid growth of drug-resistant bacteria all over the world has given rise to a major research challenge, namely a search for alternative treatments to which bacteria will be unable to develop resistance. Photodynamic therapy is an approach of this kind. It involves the use of photosensitizers in combination with visible light at a certain wavelength to excite the former and generate reactive oxygen species. Various synthetic heterocyclic compounds are used as photosensitizers. Of these, derivatives of natural chlorophylls have a special place due to their properties. This review deals with the use of such compounds in antimicrobial PDT.

Photodynamic therapy with nanoparticles to combat microbial infection and resistance

Nanoscale ◽  
2020 ◽  
Vol 12 (41) ◽  
pp. 21034-21059
Author(s):  
Alina Bekmukhametova ◽  
Herleen Ruprai ◽  
James M. Hook ◽  
Damia Mawad ◽  
Jessica Houang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Antimicrobial Photodynamic Therapy ◽  
Drug Resistant ◽  
Cellular Interactions ◽  
Microbial Infection ◽  
Recent Developments ◽  
Safety Considerations ◽  
Nanoparticulate Systems

Recent developments of nanoparticles and nanoparticulate systems in antimicrobial photodynamic therapy, focusing on drug-resistant microbes, cellular interactions, and safety considerations.

scholarly journals Development of Antimicrobial Laser-Induced Photodynamic Therapy Based on Ethylcellulose/Chitosan Nanocomposite with 5,10,15,20-Tetrakis(m-Hydroxyphenyl)porphyrin

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3551
Author(s):  
Mohamed S. Hasanin ◽  
Mohamed Abdelraof ◽  
Mohamed Fikry ◽  
Yasser M. Shaker ◽  
Ayman M. K. Sweed ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Microbial Growth ◽  
Positive Charge ◽  
Laser Light ◽  
Multidrug Resistant ◽  
Antimicrobial Photodynamic Therapy ◽  
Drug Resistant ◽  
Surface Loading ◽  
Chitosan Composite ◽  
Higher Doses

The development of new antimicrobial strategies that act more efficiently than traditional antibiotics is becoming a necessity to combat multidrug-resistant pathogens. Here we report the efficacy of laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans. Surface loading of the ethylcelllose/chitosan composite with mTHPP was carried out and the resulting nanocomposite was fully characterized. The results indicate that the prepared nanocomposite incorporates mTHPP inside, and that the composite acquired an overall positive charge. The incorporation of mTHPP into the nanocomposite enhanced the photo- and thermal stability. Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5–70 mW), and exposure times (15–45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min. Utilization of higher doses (70 mW) for longer periods achieved more eradication of microbial growth.

Regenerative treatment of peri-implantitis following implant surface decontamination with titanium brush and antimicrobial photodynamic therapy: a case series with reentry

2020 ◽  
Author(s):  
Pier Poli ◽  
Francisley Avila Souza ◽  
Mattia Manfredini ◽  
Carlo Maiorana ◽  
Mario Beretta
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Case ◽  
Case Series ◽  
Antimicrobial Photodynamic Therapy ◽  
Implant Surface ◽  
Surface Decontamination

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