Photodynamic therapy with nanoparticles to combat microbial infection and resistance

Nanoscale ◽  
2020 ◽  
Vol 12 (41) ◽  
pp. 21034-21059
Author(s):  
Alina Bekmukhametova ◽  
Herleen Ruprai ◽  
James M. Hook ◽  
Damia Mawad ◽  
Jessica Houang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Antimicrobial Photodynamic Therapy ◽  
Drug Resistant ◽  
Cellular Interactions ◽  
Microbial Infection ◽  
Recent Developments ◽  
Safety Considerations ◽  
Nanoparticulate Systems

Recent developments of nanoparticles and nanoparticulate systems in antimicrobial photodynamic therapy, focusing on drug-resistant microbes, cellular interactions, and safety considerations.

Antimicrobial Photodynamic Therapy on Drug-resistant Pseudomonas aeruginosa-induced Infection. An In Vivo Study†

2012 ◽  
Vol 88 (3) ◽  
pp. 590-595 ◽  
Author(s):  
Maria C. E. Hashimoto ◽  
Renato A. Prates ◽  
Ilka T. Kato ◽  
Silvia C. Núñez ◽  
Lília C. Courrol ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Photodynamic Therapy ◽  
In Vivo Study ◽  
Antimicrobial Photodynamic Therapy ◽  
Drug Resistant

scholarly journals Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy

2021 ◽  
Vol 22 (12) ◽  
pp. 6392
Author(s):  
Nikita Suvorov ◽  
Viktor Pogorilyy ◽  
Ekaterina Diachkova ◽  
Yuri Vasil’ev ◽  
Andrey Mironov ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Heterocyclic Compounds ◽  
Resistant Bacteria ◽  
Antimicrobial Photodynamic Therapy ◽  
Drug Resistant ◽  
Oxygen Species ◽  
Major Research ◽  
Drug Resistant Bacteria ◽  
Research Challenge ◽  
Derivatives Of

The rapid growth of drug-resistant bacteria all over the world has given rise to a major research challenge, namely a search for alternative treatments to which bacteria will be unable to develop resistance. Photodynamic therapy is an approach of this kind. It involves the use of photosensitizers in combination with visible light at a certain wavelength to excite the former and generate reactive oxygen species. Various synthetic heterocyclic compounds are used as photosensitizers. Of these, derivatives of natural chlorophylls have a special place due to their properties. This review deals with the use of such compounds in antimicrobial PDT.

scholarly journals Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 1995
Author(s):  
Raphaëlle Youf ◽  
Max Müller ◽  
Ali Balasini ◽  
Franck Thétiot ◽  
Mareike Müller ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Innovative Technology ◽  
Antimicrobial Photodynamic Therapy ◽  
Basic Principles ◽  
Current State ◽  
Recent Developments ◽  
Antimicrobial Treatments ◽  
Carrier Systems ◽  
Insight Into ◽  
New Strategies

Antimicrobial photodynamic therapy (aPDT) has become a fundamental tool in modern therapeutics, notably due to the expanding versatility of photosensitizers (PSs) and the numerous possibilities to combine aPDT with other antimicrobial treatments to combat localized infections. After revisiting the basic principles of aPDT, this review first highlights the current state of the art of curative or preventive aPDT applications with relevant clinical trials. In addition, the most recent developments in photochemistry and photophysics as well as advanced carrier systems in the context of aPDT are provided, with a focus on the latest generations of efficient and versatile PSs and the progress towards hybrid-multicomponent systems. In particular, deeper insight into combinatory aPDT approaches is afforded, involving non-radiative or other light-based modalities. Selected aPDT perspectives are outlined, pointing out new strategies to target and treat microorganisms. Finally, the review works out the evolution of the conceptually simple PDT methodology towards a much more sophisticated, integrated, and innovative technology as an important element of potent antimicrobial strategies.

scholarly journals Design of Photosensitizing Agents for Targeted Antimicrobial Photodynamic Therapy

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5239
Author(s):  
Maxime Klausen ◽  
Muhammed Ucuncu ◽  
Mark Bradley
Keyword(s):  
Photodynamic Therapy ◽  
Conventional Treatment ◽  
Building Blocks ◽  
Type I ◽  
Antimicrobial Photodynamic Therapy ◽  
Photodynamic Inactivation ◽  
Oxygen Species ◽  
Type Ii ◽  
Photosensitizing Agents ◽  
Recent Developments

Photodynamic inactivation of microorganisms has gained substantial attention due to its unique mode of action, in which pathogens are unable to generate resistance, and due to the fact that it can be applied in a minimally invasive manner. In photodynamic therapy (PDT), a non-toxic photosensitizer (PS) is activated by a specific wavelength of light and generates highly cytotoxic reactive oxygen species (ROS) such as superoxide (O2−, type-I mechanism) or singlet oxygen (1O2*, type-II mechanism). Although it offers many advantages over conventional treatment methods, ROS-mediated microbial killing is often faced with the issues of accessibility, poor selectivity and off-target damage. Thus, several strategies have been employed to develop target-specific antimicrobial PDT (aPDT). This includes conjugation of known PS building-blocks to either non-specific cationic moieties or target-specific antibiotics and antimicrobial peptides, or combining them with targeting nanomaterials. In this review, we summarise these general strategies and related challenges, and highlight recent developments in targeted aPDT.

Gold Nanoclusters Based Nanocomposites for Combinatorial Antibacterial Therapy on Biofilm Forming Pathogens

2022 ◽  
Author(s):  
Genji Srinivasulu Yuvasri ◽  
Anbu Mozhi Thamizhchelvan ◽  
Nirmal Goswami ◽  
Qiaofeng Yao ◽  
Jianping Xie
Keyword(s):  
Photodynamic Therapy ◽  
Antibacterial Therapy ◽  
Gold Nanoclusters ◽  
Bacterial Biofilm ◽  
Antimicrobial Photodynamic Therapy ◽  
Drug Resistant ◽  
Limited Capacity

Nanomaterial-based antimicrobial photodynamic therapy (aPDT) is a promising approach for the eradication of drug-resistant bacterial biofilm. However, the intrinsic cytotoxicity of the commonly used nanomaterials together with their limited capacity...

scholarly journals Development of Antimicrobial Laser-Induced Photodynamic Therapy Based on Ethylcellulose/Chitosan Nanocomposite with 5,10,15,20-Tetrakis(m-Hydroxyphenyl)porphyrin

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3551
Author(s):  
Mohamed S. Hasanin ◽  
Mohamed Abdelraof ◽  
Mohamed Fikry ◽  
Yasser M. Shaker ◽  
Ayman M. K. Sweed ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Microbial Growth ◽  
Positive Charge ◽  
Laser Light ◽  
Multidrug Resistant ◽  
Antimicrobial Photodynamic Therapy ◽  
Drug Resistant ◽  
Surface Loading ◽  
Chitosan Composite ◽  
Higher Doses

The development of new antimicrobial strategies that act more efficiently than traditional antibiotics is becoming a necessity to combat multidrug-resistant pathogens. Here we report the efficacy of laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans. Surface loading of the ethylcelllose/chitosan composite with mTHPP was carried out and the resulting nanocomposite was fully characterized. The results indicate that the prepared nanocomposite incorporates mTHPP inside, and that the composite acquired an overall positive charge. The incorporation of mTHPP into the nanocomposite enhanced the photo- and thermal stability. Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5–70 mW), and exposure times (15–45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min. Utilization of higher doses (70 mW) for longer periods achieved more eradication of microbial growth.

Regenerative treatment of peri-implantitis following implant surface decontamination with titanium brush and antimicrobial photodynamic therapy: a case series with reentry

2020 ◽  
Author(s):  
Pier Poli ◽  
Francisley Avila Souza ◽  
Mattia Manfredini ◽  
Carlo Maiorana ◽  
Mario Beretta
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Case ◽  
Case Series ◽  
Antimicrobial Photodynamic Therapy ◽  
Implant Surface ◽  
Surface Decontamination

Not required for Clinical case letters according to the authors' guidelines.

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