GlyConnect-Ugi: Site-selective, multi-component glycoprotein conjugations through GlycoDelete expressed glycans.

2021 ◽  
Author(s):  
Karel Thooft ◽  
Wander Van Breedam ◽  
Francis Santens ◽  
Elise Wyseure ◽  
Sandrine Vanmarcke ◽  
...  
Keyword(s):  
Protein Conjugation ◽  
A Site ◽  
Site Selective ◽  
Gc Protein

Recently, the GlyConnect (GC) protein conjugation strategy was developed to provide a site-selective glycan-based conjugation strategy as an extension to the in-house developed GlycoDelete (GD) technology. GD gives access to...

scholarly journals Site-selective protein conjugation at histidine

2019 ◽  
Vol 10 (2) ◽  
pp. 427-439 ◽  
Author(s):  
Karolina Peciak ◽  
Emmanuelle Laurine ◽  
Rita Tommasi ◽  
Ji-won Choi ◽  
Steve Brocchini
Keyword(s):  
Molecular Engineering ◽  
Protein Conjugation ◽  
Site Specific ◽  
A Site ◽  
Site Selective

Site-selective conjugation generally requires both (i) molecular engineering of the protein of interest to introduce a conjugation site at a defined location and (ii) a site-specific conjugation technology.

Chemical and Electrochemical Heteroepitaxial Growth of Chalcogenide Semiconductors from Solutions

1996 ◽  
Vol 451 ◽  
Author(s):  
D. Lincot ◽  
M. J. Furlong ◽  
M. Froment ◽  
R. Cortes ◽  
M. C. Bernard
Keyword(s):  
Heteroepitaxial Growth ◽  
X Ray Diffraction ◽  
Basic Principles ◽  
Lattice Match ◽  
X Ray ◽  
Chalcogenide Semiconductors ◽  
Influence Of Temperature On ◽  
Deposition Processes ◽  
A Site ◽  
Site Selective

ABSTRACTChalcogenide semiconductors have been deposited epitaxially from aqueous solutions either chemically or electrochemically at growth rates of up to 0.7 μmhr−1. After recalling the basic principles of these deposition processes, results are presented concerning chemically deposited CdS on InP, GaP and CuInSe2 substrates, electrodeposited CdTe on InP, and CdSAnP heterostructures. Characterisation of these structures by RHEED, TEM, HRTEM, and glazing angle X ray diffraction allows to analyse the effects of substrate orientation, polarity, lattice match plus the influence of temperature on epitaxial growth. These results are discussed in terms of self organisation and a site selective growth mechanisms due to the free enegy of formation of each compound.

A Site‐Selective C−N Bond Formation of 2,4‐Dichloro‐5 H ‐pyrano[2,3‐ d ]pyrimidines and Amide

2021 ◽  
Vol 6 (43) ◽  
pp. 12032-12035
Author(s):  
Jinjing Qin ◽  
Zhenhua Li ◽  
Yingyan Cao ◽  
Yuanyuan Xie ◽  
Weike Su
Keyword(s):  
Bond Formation ◽  
A Site ◽  
Site Selective

Abstract 1304: AbYlinkTM: A site-selective labeling method for preclinical imaging of therapeutic antibodies

2021 ◽  
Author(s):  
Viktoriia Postupalenko ◽  
Léo Marx ◽  
David Viertl ◽  
Natalia Gasilova ◽  
Mathilde Plantin ◽  
...  
Keyword(s):  
Therapeutic Antibodies ◽  
Selective Labeling ◽  
Preclinical Imaging ◽  
A Site ◽  
Site Selective ◽  
Labeling Method

Catalyst-Controlled Site-Selective N-H and C3-Arylation of Carba-zole via Carbene Transfer Reactions

2021 ◽  
Author(s):  
Sourav Sekhar Bera ◽  
Srishti Ballabh Bahukhandi ◽  
Claire Empel ◽  
Rene M Koenigs
Keyword(s):  
Transfer Reactions ◽  
Palladium Acetate ◽  
Direct Arylation ◽  
Carbene Transfer ◽  
A Site ◽  
Site Selective

A site-selective direct arylation reaction of carbazole and other N-heterocycles with diazo-naphthalen-2(1H)-ones has been developed. While Au(I)-NHC catalysts lead to selective C3-arylation, palladium acetate allows for selective N-H arylation, displaying...

Nickel-Catalyzed Regioselective Carbomagnesation of Methylenecyclopropanes through a Site-Selective Carbon-Carbon Bond Cleavage

2009 ◽  
Vol 49 (1) ◽  
pp. 144-147 ◽  
Author(s):  
Jun Terao ◽  
Masahiro Tomita ◽  
Surya Prakash Singh ◽  
Nobuaki Kambe
Keyword(s):  
Bond Cleavage ◽  
Carbon Bond ◽  
Carbon Carbon Bond ◽  
A Site ◽  
Site Selective

scholarly journals Site-Selective C-C Modification of Proteins at Neutral pH Using Organocatalyst-Mediated Cross Aldol Ligations

2018 ◽  
Author(s):  
Martin A. Fascione ◽  
Richard J. Spears ◽  
Robin L. Brabham ◽  
Darshita Budhadev ◽  
Tessa Keenan ◽  
...  
Keyword(s):  
Small Molecules ◽  
Stable Carbon ◽  
Biological Mechanisms ◽  
Large Excess ◽  
Reaction Conditions ◽  
Chemical Methods ◽  
Neutral Ph ◽  
Chemical Modification Of Proteins ◽  
A Site ◽  
Site Selective

The bioconjugation of proteins with small molecules has proved an invaluable strategy for probing and perturbing dynamic biological mechanisms. The general use of chemical methods for the functionalisation of proteins remains limited however by the frequent requirement for complicated reaction partners to be present in large excess, and harsh reaction conditions which are incompatible with many protein scaffolds. Herein we describe a site-selective organocatalyst-mediated protein aldol ligation (OPAL) that affords stable carbon-carbon linked bioconjugates at neutral pH under biocompatible conditions. OPAL enables rapid chemical modification of proteins within an hour using simple aldehyde probes in minimal excess, and is utilised here in the selective affinity tagging of proteins in cell lysate. Furthermore we demonstrate that the b-hydroxy aldehyde product of the OPAL can be functionalised a second time at neutral pH in a subsequent organocatalyst-mediated oxime ligation. This tandem strategy is showcased in the ‘chemical mimicry’ of a previously inaccessible natural dual post-translationally modified protein integral to the pathogenesis of the neglected tropical disease Leishmaniasis. <br>

Building Addressable Libraries: Olefin Functionalization Reactions and the Development of a Site-Selective, Cleavable Linker

2021 ◽  
Vol MA2021-01 (42) ◽  
pp. 1727-1727
Author(s):  
Nai-Hua Yeh ◽  
Albert Huang ◽  
Kevin D Moeller
Keyword(s):  
A Site ◽  
Site Selective

scholarly journals Chiral Chalcogen Bond Donors Based on the 4,4′-Bipyridine Scaffold

Molecules ◽  
2019 ◽  
Vol 24 (24) ◽  
pp. 4484 ◽  
Author(s):  
Robin Weiss ◽  
Emmanuel Aubert ◽  
Paola Peluso ◽  
Sergio Cossu ◽  
Patrick Pale ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
High Performance ◽  
Chiral Stationary Phase ◽  
Asymmetric Induction ◽  
Selenium Compound ◽  
Design And Synthesis ◽  
Catalytically Active ◽  
A Site ◽  
Site Selective ◽  
Proof Of Principle

Organocatalysis through chalcogen bonding (ChB) is in its infancy, as its proof-of-principle was only reported in 2016. Herein, we report the design and synthesis of new chiral ChB donors, as well as the catalytic activity evaluation of the 5,5′-dibromo-2,2′-dichloro-3-((perfluorophenyl)selanyl)-4,4′-bipyridine as organocatalyst. The latter is based on the use of two electron-withdrawing groups, a pentafluorophenyl ring and a tetrahalo-4,4′-bipyridine skeleton, as substituents at the selenium center. Atropisomery of the tetrahalo-4,4′-bipyridine motif provides a chiral environment to these new ChB donors. Their synthesis was achieved through either selective lithium exchange and trapping or a site-selective copper-mediated reaction. Pure enantiomers of the 3-selanyl-4,4′-bipyridine were obtained by high performance liquid chromatography enantioseparation on specific chiral stationary phase, and their absolute configuration was assigned by comparison of the measured and calculated electronic circular dichroism spectra. The capability of the selenium compound to participate in σ-hole-based interactions in solution was studied by 19F NMR. Even if no asymmetric induction has been observed so far, the new selenium motif proved to be catalytically active in the reduction of 2-phenylquinoline by Hantzsch ester.

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