Catalyst-free and multicomponent synthesis of 3-aminoalkylated indoles via Mannich-type reaction: multitargeted anticancer, tyrosinase and α-glucosidase inhibitory activities

2021 ◽  
Author(s):  
Dung Thi-Kim Hoang ◽  
Kim-Chi T. Huynh ◽  
Huy Kim-Khanh Ngo ◽  
Phuc Hoang Nguyen ◽  
Khanh Hoai Dang ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Multicomponent Synthesis ◽  
Type Reaction ◽  
Catalyst Free ◽  
Highly Efficient ◽  
Inhibitory Activities

Highly efficient and sustainable approach for the multi-component synthesis of 3-aminoalkylated indoles was investigated via Mannich-type reaction under catalyst-free, methanol and ethylene glycol (EG) as promoting media. Synthesizing various substrates...

Catalyst-free, Solvent-promoted and Scalable Multicomponent Synthesis of 3-Aminoalkylated Indoles via a Mannich-type Reaction

2014 ◽  
Vol 69 (6) ◽  
pp. 721-727 ◽  
Author(s):  
Jian-Fei Cao ◽  
Yan-Li Chen ◽  
Zhi Guan ◽  
Yan-Hong He
Keyword(s):  
Aromatic Aldehydes ◽  
Secondary Amines ◽  
Multicomponent Synthesis ◽  
Type Reaction ◽  
Catalyst Free

A catalyst-free, solvent-promoted and scalable three-component Mannich-type reaction of indoles, aromatic aldehydes and secondary amines for the synthesis of 3-(1-dialkylaminoalkyl)-1H-indoles has been developed. The protocol provided a mild, simple and highly atom-economic alternative to prepare the title compounds, and the corresponding products could be obtained in good to excellent yields in most cases.

Catalyst-free ultrasonic-promoted multicomponent synthesis of tertiary α-amino phosphonates

2017 ◽  
Vol 41 (14) ◽  
pp. 6653-6660 ◽  
Author(s):  
Reddi Mohan Naidu Kalla ◽  
Jaeyeong Bae ◽  
Il Kim
Keyword(s):  
Ultrasound Irradiation ◽  
Multicomponent Synthesis ◽  
Green Protocol ◽  
Catalyst Free ◽  
Highly Efficient ◽  
Amino Phosphonates

A highly efficient and green protocol has been developed for the synthesis of novel tertiary α-amino phosphonates via a catalyst-free multi-component Kabachnik–Fields reaction under ultrasound irradiation.

Catalyst-free, ethylene glycol promoted one-pot three component synthesis of 3-amino alkylated indoles via Mannich-type reaction

2014 ◽  
Vol 55 (18) ◽  
pp. 2977-2981 ◽  
Author(s):  
U. Chinna Rajesh ◽  
Rohit Kholiya ◽  
V. Satya Pavan ◽  
Diwan S. Rawat
Keyword(s):  
Ethylene Glycol ◽  
One Pot ◽  
Type Reaction ◽  
Catalyst Free

ChemInform Abstract: Catalyst-Free, Ethylene Glycol Promoted One-Pot Three Component Synthesis of 3-Amino Alkylated Indoles via Mannich-Type Reaction.

ChemInform ◽  
2014 ◽  
Vol 45 (42) ◽  
pp. no-no
Author(s):  
U. Chinna Rajesh ◽  
Rohit Kholiya ◽  
V. Satya Pavan ◽  
Diwan S. Rawat
Keyword(s):  
Ethylene Glycol ◽  
One Pot ◽  
Type Reaction ◽  
Catalyst Free

Catalyst-free multicomponent synthesis of novel adamantyl-containing tetrahydropyrimidine carboxylates

2016 ◽  
Vol 20 (3) ◽  
pp. 581-590 ◽  
Author(s):  
Utpalparna Kalita ◽  
Shunan Kaping ◽  
Jai Narain Vishwakarma
Keyword(s):  
Multicomponent Synthesis ◽  
Catalyst Free

Heterogenization of amine-functionalized ionic liquids using graphene oxide as a support material: a highly efficient catalyst for the synthesis of 3-substituted indoles via Yonemitsu-type reaction

2017 ◽  
Vol 41 (24) ◽  
pp. 15545-15554 ◽  
Author(s):  
Charu Garkoti ◽  
Javaid Shabir ◽  
Padmini Gupta ◽  
Manisha Sharma ◽  
Subho Mozumdar
Keyword(s):  
Ionic Liquid ◽  
Graphene Oxide ◽  
Ionic Liquids ◽  
Recyclable Catalyst ◽  
Support Material ◽  
Efficient Catalyst ◽  
Functionalized Ionic Liquid ◽  
Type Reaction ◽  
Highly Efficient ◽  
Amine Functionalized

Heterogenization of amine functionalized ionic liquid and its application as an efficient and recyclable catalyst.

Highly efficient and catalyst-free synthesis of substituted thioureas in water

2011 ◽  
Vol 15 (3) ◽  
pp. 809-815 ◽  
Author(s):  
Shi-Feng Gan ◽  
Jie-Ping Wan ◽  
Yuan-Jiang Pan ◽  
Cui-Rong Sun
Keyword(s):  
Catalyst Free ◽  
Highly Efficient
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