ChemInform Abstract: Catalyst-Free, Ethylene Glycol Promoted One-Pot Three Component Synthesis of 3-Amino Alkylated Indoles via Mannich-Type Reaction.

ChemInform ◽  
2014 ◽  
Vol 45 (42) ◽  
pp. no-no
Author(s):  
U. Chinna Rajesh ◽  
Rohit Kholiya ◽  
V. Satya Pavan ◽  
Diwan S. Rawat
Keyword(s):  
Ethylene Glycol ◽  
One Pot ◽  
Type Reaction ◽  
Catalyst Free

Catalyst-free, ethylene glycol promoted one-pot three component synthesis of 3-amino alkylated indoles via Mannich-type reaction

2014 ◽  
Vol 55 (18) ◽  
pp. 2977-2981 ◽  
Author(s):  
U. Chinna Rajesh ◽  
Rohit Kholiya ◽  
V. Satya Pavan ◽  
Diwan S. Rawat
Keyword(s):  
Ethylene Glycol ◽  
One Pot ◽  
Type Reaction ◽  
Catalyst Free

Catalyst-free and multicomponent synthesis of 3-aminoalkylated indoles via Mannich-type reaction: multitargeted anticancer, tyrosinase and α-glucosidase inhibitory activities

2021 ◽  
Author(s):  
Dung Thi-Kim Hoang ◽  
Kim-Chi T. Huynh ◽  
Huy Kim-Khanh Ngo ◽  
Phuc Hoang Nguyen ◽  
Khanh Hoai Dang ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Multicomponent Synthesis ◽  
Type Reaction ◽  
Catalyst Free ◽  
Highly Efficient ◽  
Inhibitory Activities

Highly efficient and sustainable approach for the multi-component synthesis of 3-aminoalkylated indoles was investigated via Mannich-type reaction under catalyst-free, methanol and ethylene glycol (EG) as promoting media. Synthesizing various substrates...

scholarly journals An Efficient, Clean, and Catalyst-Free Synthesis of Fused Pyrimidines Using Sonochemistry

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
M. Mamaghani ◽  
K. Tabatabaeian ◽  
R. Araghi ◽  
A. Fallah ◽  
R. Hossein Nia
Keyword(s):  
Ethylene Glycol ◽  
Ultrasonic Irradiation ◽  
Reaction Times ◽  
Quinoline Derivatives ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
Catalyst Free ◽  
Three Component Reaction

In this report, synthesis of indenopyrido[2,3-d]pyrimidine and pyrimido[4,5-b]quinoline derivatives was investigated via one-pot three-component reaction between 6-amino-2-(alkylthio)-pyrimidin-4(3H)one, 1,3-indanedione, or 1,3-cyclohexadione and arylaldehyde under ultrasonic irradiation in ethylene glycol as solvent at 65°C. In these reactions fused pyrimidine derivatives were synthesized with high to excellent yields (82–97%) and short reaction times (10–33 min).

Catalyst-Free Synthesis of 3-(2-Quinolinemethylene)-Substituted Isoindolinones in Water

Synthesis ◽  
2018 ◽  
Vol 50 (11) ◽  
pp. 2255-2265 ◽  
Author(s):  
Feng Xu ◽  
Youping Tian ◽  
Jialin Sun ◽  
Kaihua Zhang ◽  
Gaoqiang Li
Keyword(s):  
Intramolecular Cyclization ◽  
Environmentally Benign ◽  
Primary Amines ◽  
One Pot ◽  
Direct Construction ◽  
Type Reaction ◽  
Catalyst Free

A facile and environmentally benign approach toward the synthesis of novel 3-alkyl-substituted isoindolinones by three-component reactions of 2-formylbenzoic acids, primary amines and 2-methyl­azaarenes in water under catalyst- and additive-free conditions is described. This protocol features the direct construction of multiple C–N and C–C bonds via a tandem Mannich-type reaction and intramolecular cyclization in a one-pot fashion, affording the desired 3-(2-quinolinemethylene)-substituted isoindolinones in high to excellent yields.

Metal-Free Photoinduced Hydroalkylation Cascade Enabled by an Electron-Donor-Acceptor Complex

2020 ◽  
Author(s):  
José Tiago Menezes Correia ◽  
Gustavo Piva da Silva ◽  
Camila Menezes Kisukuri ◽  
Elias André ◽  
Bruno Pires ◽  
...  
Keyword(s):  
Electron Donor ◽  
Functional Group ◽  
Photoexcited Electron ◽  
One Pot ◽  
Quaternary Centers ◽  
Metal Free ◽  
Acceptor Complex ◽  
Catalyst Free ◽  
Donor Acceptor ◽  
Radical Cascade

A metal- and catalyst-free photoinduced radical cascade hydroalkylation of 1,7-enynes has been disclosed. The process is triggered by a SET event involving a photoexcited electron-donor-aceptor complex between NHPI ester and Hantzsch ester, which decomposes to afford a tertiary radical that is readily trapped by the enyne. <a>The method provides an operationally simple, robust and step-economical approach to the construction of diversely functionalized dihydroquinolinones bearing quaternary-centers. A sequential one-pot hydroalkylation-isomerization approach is also allowed giving access to a family of quinolinones. A wide substrate scope and high functional group tolerance was observed in both approaches</a>.

Novel One-pot Synthesis of Pyranocarbazole Derivatives via an Isocyanide-based Three-component Reaction

2020 ◽  
Vol 17 ◽  
Author(s):  
Visarapu Malathi ◽  
Pedavenkatagari Narayana Reddy ◽  
Pannala Padmaja
Keyword(s):  
Efficient Method ◽  
Atom Economy ◽  
Reaction Conditions ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
High Yields

Abstract:: An efficient method has been developed for the synthesis of new pyrano[3,2-c] and pyrano[3,2-a]carbazole de-rivatives via a three component reaction of 4-hydroxycarbazole or 2-hydroxycarbazole, isocyanides, and dialkylacetylenedi-carboxylates. Noteworthy features of this protocol include mild reaction conditions, catalyst-free, high atom-economy and high yields.

Catalyst-free synthesis of phenanthridines via electrochemical coupling of 2-isocyanobiphenyls and amines

2021 ◽  
Vol 45 (14) ◽  
pp. 6367-6378
Author(s):  
Bhanwar Kumar Malviya ◽  
Karandeep Singh ◽  
Pradeep K. Jaiswal ◽  
Manvika Karnatak ◽  
Ved Prakash Verma ◽  
...  
Keyword(s):  
One Pot ◽  
Metal Free ◽  
Catalyst Free ◽  
Electrochemical Coupling

One pot metal-free synthesis of phenanthridines and amides under electrochemical conditions.

Synthesis of isoxazolidines via catalyst-free one-pot three-component cycloaddition of sulfoxonium ylides, nitrosoarenes and alkenes

2021 ◽  
Author(s):  
Xing Li ◽  
Pingan Zhai ◽  
Yongsheng Fang ◽  
Wenhui Li ◽  
Honghong Chang ◽  
...  
Keyword(s):  
One Pot ◽  
Catalyst Free ◽  
Practical Strategy ◽  
Three Component Reaction

A general and practical strategy for the construction of various keto-substituted isoxazolidines via one-pot three-component reaction of easily accessible, safer and more stable sulfoxonium ylides, nitrosoarenes and olefins is described.

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