ChemInform Abstract: Catalyst-Free, Solvent-Promoted and Scalable Multicomponent Synthesis of 3-Aminoalkylated Indoles via a Mannich-Type Reaction.

ChemInform ◽  
2015 ◽  
Vol 46 (1) ◽  
Author(s):  
Jian-Fei Cao ◽  
Yan-Li Chen ◽  
Zhi Guan ◽  
Yan-Hong He
Keyword(s):  
Multicomponent Synthesis ◽  
Type Reaction ◽  
Catalyst Free

Catalyst-free, Solvent-promoted and Scalable Multicomponent Synthesis of 3-Aminoalkylated Indoles via a Mannich-type Reaction

2014 ◽  
Vol 69 (6) ◽  
pp. 721-727 ◽  
Author(s):  
Jian-Fei Cao ◽  
Yan-Li Chen ◽  
Zhi Guan ◽  
Yan-Hong He
Keyword(s):  
Aromatic Aldehydes ◽  
Secondary Amines ◽  
Multicomponent Synthesis ◽  
Type Reaction ◽  
Catalyst Free

A catalyst-free, solvent-promoted and scalable three-component Mannich-type reaction of indoles, aromatic aldehydes and secondary amines for the synthesis of 3-(1-dialkylaminoalkyl)-1H-indoles has been developed. The protocol provided a mild, simple and highly atom-economic alternative to prepare the title compounds, and the corresponding products could be obtained in good to excellent yields in most cases.

Catalyst-free and multicomponent synthesis of 3-aminoalkylated indoles via Mannich-type reaction: multitargeted anticancer, tyrosinase and α-glucosidase inhibitory activities

2021 ◽  
Author(s):  
Dung Thi-Kim Hoang ◽  
Kim-Chi T. Huynh ◽  
Huy Kim-Khanh Ngo ◽  
Phuc Hoang Nguyen ◽  
Khanh Hoai Dang ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Multicomponent Synthesis ◽  
Type Reaction ◽  
Catalyst Free ◽  
Highly Efficient ◽  
Inhibitory Activities

Highly efficient and sustainable approach for the multi-component synthesis of 3-aminoalkylated indoles was investigated via Mannich-type reaction under catalyst-free, methanol and ethylene glycol (EG) as promoting media. Synthesizing various substrates...

Catalyst-free multicomponent synthesis of novel adamantyl-containing tetrahydropyrimidine carboxylates

2016 ◽  
Vol 20 (3) ◽  
pp. 581-590 ◽  
Author(s):  
Utpalparna Kalita ◽  
Shunan Kaping ◽  
Jai Narain Vishwakarma
Keyword(s):  
Multicomponent Synthesis ◽  
Catalyst Free

Grinding induced catalyst free, multicomponent synthesis of Indoloindole pyrimidine

2020 ◽  
Vol 61 (41) ◽  
pp. 152383
Author(s):  
Suresh Kumar Maury ◽  
Savita Kumari ◽  
Ambuj Kumar Kushwaha ◽  
Arsala Kamal ◽  
Himanshu Kumar Singh ◽  
...  
Keyword(s):  
Multicomponent Synthesis ◽  
Catalyst Free

ChemInform Abstract: Catalyst-Free Synthesis of Trisubstituted Tetrahydrothiophenes in Water via a Cascade Sulfa-Michael/Aldol (Henry) Type Reaction.

ChemInform ◽  
2015 ◽  
Vol 46 (17) ◽  
pp. no-no
Author(s):  
Jian Song ◽  
Jamia Moss ◽  
Da-Cheng Yang ◽  
Zhi Guan ◽  
Yan-Hong He
Keyword(s):  
Type Reaction ◽  
Catalyst Free

In situ generation and protonation of the isocyanide/acetylene adduct: a powerful catalyst-free strategy for multicomponent synthesis of ketenimines, aza-dienes, and heterocycles

RSC Advances ◽  
2015 ◽  
Vol 5 (117) ◽  
pp. 97044-97065 ◽  
Author(s):  
Sadegh Rostamnia
Keyword(s):  
Multicomponent Reactions ◽  
Multicomponent Synthesis ◽  
New Class ◽  
Catalyst Free ◽  
In Situ Generation

In addition to isocyanide-based Ugi, Passerini, van Leusen, and Orru multicomponent reactions, a new class of isocyanide/acetylene-based multicomponent reactions, using zwitterionic adducts, have emerged as powerful methods to synthesize biologically interesting molecules.

Catalyst-free synthesis of trisubstituted tetrahydrothiophenes in water via a cascade sulfa-Michael/aldol (Henry) type reaction

RSC Advances ◽  
2014 ◽  
Vol 4 (96) ◽  
pp. 54032-54038 ◽  
Author(s):  
Jian Song ◽  
Jamia Moss ◽  
Da-Cheng Yang ◽  
Zhi Guan ◽  
Yan-Hong He
Keyword(s):  
Type Reaction ◽  
Catalyst Free

ChemInform Abstract: A Catalyst- and Solvent-Free Multicomponent Synthesis of 7-Azagramine Analogues via a Mannich Type Reaction

ChemInform ◽  
2016 ◽  
Vol 47 (22) ◽  
Author(s):  
Sakharam B. Dongare ◽  
Hemant V. Chavan ◽  
Pravin S. Bhale ◽  
Yoginath B. Mule ◽  
Amol S. Kotmale ◽  
...  
Keyword(s):  
Solvent Free ◽  
Multicomponent Synthesis ◽  
Type Reaction

A One-Pot, Multicomponent Synthesis of Trifluoromethylated Spiropiperidines under Catalyst-Free Conditions

Synthesis ◽  
2016 ◽  
Vol 48 (20) ◽  
pp. 3527-3536 ◽  
Author(s):  
Liping Song ◽  
Wei Shi ◽  
Yang Wang ◽  
Yingjun Zhu ◽  
Min Zhang ◽  
...  
Keyword(s):  
Multicomponent Synthesis ◽  
One Pot ◽  
Catalyst Free
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