Drug-loading colloidal gels assembled from polymeric nanoparticles as an anti-inflammatory platform

2021 ◽  
Author(s):  
Jinkun Yin ◽  
Yaoqing Chu ◽  
Si-Jian Pan ◽  
Lianjiang Tan
Keyword(s):  
Efficient Method ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Direct Injection ◽  
Colloidal Gels ◽  
Local Inflammation ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Precise treatment of local inflammation is always challenging. Administration of anti-inflammatory drugs by direct injection has been considered as an efficient method for inflammation inhibition. In the present work, injectable...

scholarly journals Preparation and characterization of N-benzyl-N,O-succinyl chitosan polymeric micelles for solubilization of poorly soluble non-steroidal anti-inflammatory drugs

2017 ◽  
Vol 16 (10) ◽  
pp. 2349-2357
Author(s):  
Thisirak Woraphatphadung ◽  
Warayuth Sajomsang ◽  
Theerasak Rojanarata ◽  
Prasert Akkaramongkolporn ◽  
Tanasait Ngawhirunpat ◽  
...  
Keyword(s):  
Particle Size ◽  
Surface Charge ◽  
Polymeric Micelles ◽  
Rank Order ◽  
Drug Loading ◽  
Polymer Concentration ◽  
Water Soluble ◽  
Loading Efficiency ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Purpose: To investigate the solubilization of poorly water-soluble non-steroidal  anti-inflammatory drugs (NSAIDs) in N-benzyl-N,O-succinyl chitosan (BSCS)  polymeric micellesMethods: BSCS was synthesized by reductive amination and succinylation,  respectively. NSAIDs; meloxicam (MX), piroxicam (PRX), ketoprofen (KP) and indomethacin (IND) were entrapped in the hydrophobic inner cores by evaporation method. The effects of drug structure on loading efficiency, particle size and surface charge of micelles were investigated.Results: The critical micelle concentration of BSCS micelles was 0.0385 mg/mL and cytotoxicity on Caco-2 cells depends on the polymer concentration (IC50 = 3.23 ± 0.08 mg/mL). BSCS micelles were able to entrap MX, PRX, KP and IND and also improve the solubility of drugs. Drug loading efficiency was highly dependent on the drug molecules. The drug loading capacity of these BSCS micelles was in the following rank order: KP (282.9 μg/mg) > PRX (200.8 μg/mg) > MX (73.7 μg/mg) > IND (41.2 μg/mg). The highest loading efficiency was observed in KP-loaded BSCS micelles due to the attractive force between phenyl groups of KP and benzyl groups of the polymer. Particle size and surface charge were in the range of 312 - 433 nm and -38 to -41 mV, respectively.Conclusion: BSCS copolymer presents desirable attributes for enhancing the  solubility of hydrophobic drugs. Moreover, BSCS polymeric micelles might be beneficial carrier in a drug delivery system.Keywords: BSCS, polymeric micelles, solubilization, non-steroidal anti-inflammatory drugs

scholarly journals Nonsteroidal anti-inflammatory drugs causing local inflammation of tissue at the site of injection

2016 ◽  
Vol 7 (1) ◽  
pp. 26 ◽  
Author(s):  
AntonAleksandrovich Kasatkin ◽  
AlexandrA Urakov ◽  
IlyaAleksandrovich Lukoyanov
Keyword(s):  
Local Inflammation ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals The breast cancer stem cell potency of copper(ii) complexes bearing nonsteroidal anti-inflammatory drugs and their encapsulation using polymeric nanoparticles

2016 ◽  
Vol 45 (44) ◽  
pp. 17867-17873 ◽  
Author(s):  
Arvin Eskandari ◽  
Janine N. Boodram ◽  
Paul B. Cressey ◽  
Chunxin Lu ◽  
Peter M. Bruno ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Metal Complexes ◽  
Polymeric Nanoparticles ◽  
Breast Cancer Stem Cell ◽  
First Report ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

This is the first report to demonstrate that polymeric nanoparticles can be used to effectively deliver CSC-potent metal complexes into CSCs.

scholarly journals Modern approaches to the treatment of sore throat

2020 ◽  
pp. 31-34
Author(s):  
A. Yu. Ovchinnikov ◽  
N. A. Mirochnichenkо ◽  
V. A. Ekaterinchev
Keyword(s):  
Respiratory Tract ◽  
Upper Respiratory Tract ◽  
Local Inflammation ◽  
Protective Mechanisms ◽  
Vital Functions ◽  
Air Stream ◽  
Inflammatory Drugs ◽  
Upper Respiratory ◽  
Anti Inflammatory ◽  
Rapid Relief

The larynx is the first part of the respiratory and digestive tract and it performs vital functions. The air stream, passing through the throat and coming into contact with its mucous membrane, is moistened, warmed up and purified. Due to the anatomical structure of the mouth cavity and pharynx, it creates conditions for entry, presence and inactivation of microorganisms, viruses and fungi. Under normal conditions, due to effective protective mechanisms (mucociliary and immune), pathogens are trapped in the upper respiratory tract while the lower sections remain «clean». Acute pharyngitis is a widespread, polyetiological disease of the upper respiratory tract. There are quite a few preconditions for its development. A favorable background for local inflammation is the reduction of specific and non-specific protection factors, which may be observed in the existing chronic inflammation and worsened in diabetes mellitus and metabolic syndrome, with prolonged use of cytostatics and/or glucocorticosteroids and many other immunocompromised conditions. Due to the prevalence of pharyngitis, the development of effective screening and treatment methods is particularly relevant. Given the localized nature of inflammatory process in the pharynx and the possibility of side effects, general anti-inflammatory drugs are used less and less frequently, and local non-steroidal anti-inflammatory drugs are increasingly drawing the attention of physicians. The article discusses the possibilities and effectiveness of the medication based on benzidamine hydrochloride in treating pharyngitis of diverse etiology. The article presents the studies of foreign scientists, as well as dosages and peculiarities of the medication application. Treatment of acute tonsillipharyngitis with local non-steroidal anti-inflammatory drugs is commonly accepted and widely used in the practice of pediatricians, therapists and otorhinolaryngologists and allows to achieve rapid relief of the patient’s condition.

Polyphenols from Cymbopogon citratus inhibit iNOS expression and NO production – a promising source of new anti-inflammatory drugs

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
V Francisco ◽  
A Figueirinha ◽  
B Neves ◽  
C Garcia-Rodriguez ◽  
M Lopes ◽  
...  
Keyword(s):  
Inos Expression ◽  
No Production ◽  
Cymbopogon Citratus ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Promising Source
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