Prodrug-Based Self-Assembled Nanoparticles Formed by 3′,5′-Dioleoyl Floxuridine for Cancer Chemotherapy

2021 ◽  
Author(s):  
Hui Xu ◽  
Yue Xiao ◽  
Jinlu Tang ◽  
Dongfang Liu ◽  
Xinxin Shi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Treatment ◽  
Cancer Chemotherapy ◽  
Adverse Side Effects ◽  
Self Assembled

Chemotherapy for cancer treatment is wildly used but remain restricted by several limitations, including inefficient drug delivery and concomitant adverse side effects. Herein, we reported a new prodrug-based self-assembled nanoparticle...

Self-assembled micelles of PEG–poly(disulfide carbamate amine) copolymers for intracellular dual-responsive drug delivery

2016 ◽  
Vol 4 (5) ◽  
pp. 902-909 ◽  
Author(s):  
Chao Lin ◽  
Bo Lou ◽  
Jie Zhao ◽  
Rong Jin ◽  
Peng Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Chemotherapy ◽  
Dual Responsive ◽  
Biodegradable Poly ◽  
Self Assembled

Self-assembled nanomicelles based on biodegradable poly(carbamate) copolymers are applicable for pH and redox dual-responsive release of doxorubicin (Dox) and cancer chemotherapy.

scholarly journals Natural Phytochemicals Derived from Gymnosperms in the Prevention and Treatment of Cancers

2021 ◽  
Vol 22 (12) ◽  
pp. 6636
Author(s):  
Tayyebeh Ghaffari ◽  
Joo-Hyun Hong ◽  
Solmaz Asnaashari ◽  
Safar Farajnia ◽  
Abbas Delazar ◽  
...  
Keyword(s):  
Side Effects ◽  
Cancer Treatment ◽  
Anticancer Drug ◽  
Cancer Chemotherapy ◽  
Natural Compounds ◽  
Pine Bark ◽  
Anticancer Activities ◽  
Anticancer Compounds ◽  
Prevention And Treatment ◽  
Rational Understanding

The incidence of various types of cancer is increasing globally. To reduce the critical side effects of cancer chemotherapy, naturally derived compounds have been considered for cancer treatment. Gymnosperms are a group of plants found worldwide that have traditionally been used for therapeutic applications. Paclitaxel is a commercially available anticancer drug derived from gymnosperms. Other natural compounds with anticancer activities, such as pinostrobin and pinocembrin, are extracted from pine heartwood, and pycnogenol and enzogenol from pine bark. Gymnosperms have great potential for further study for the discovery of new anticancer compounds. This review aims to provide a rational understanding and the latest developments in potential anticancer compounds derived from gymnosperms.

scholarly journals Formulation Development, Characterization and In-vitro Evaluation of Tamoxifen Loaded Liposomes

2020 ◽  
pp. 64-82
Author(s):  
Md. Mazed Hasan ◽  
Md. Hamiduzzaman ◽  
Ishrat Jahan ◽  
A. H. M. Nazmul Hasan ◽  
Md. Asaduzzaman
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Side Effects ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ex Vivo ◽  
Release Kinetics ◽  
Formulation Development

Background: The study was aimed to prepare and evaluate tamoxifen loaded controlled release liposomes to reduce the side effects of tamoxifen during cancer treatment.  Methods: Different tamoxifen loaded liposomes were prepared by modified ether injection (MEIM) and thin film hydration method (TFHM) under prescribed conditions. The prepared liposomes were characterized by using optical microscopy, evaluating encapsulation efficiency, in-vitro and ex-vivo diffusion studies by using dialysis membrane and chicken intestinal sac respectively. Results: The data revealed that all of the liposomes were spherical in shape and stable under three physical conditions i.e. 4, 25 and 37 ± 2°C temperatures and 60 ±5% relative humidity. Additionally most of the liposomes followed zero order and class II release kinetics. It was also observed that with the increase of phospholipids and cholesterol, entrapment efficiency of liposome vesicles increased thus giving a controlled release drug delivery system but further increase reduced this efficiency at a certain level. Conclusion: The formulated control release liposomes might be a good drug delivery system for target oriented drug delivery with minimum side effects of tamoxifen during cancer treatment.

scholarly journals Resveratrol as a potential broad-spectrum compound for cancer treatment

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Li Kar Stella Tan ◽  
Chee Wun How ◽  
Jhi Biau Foo ◽  
Kooi Yeong Khaw ◽  
Bey Hing Goh ◽  
...  
Keyword(s):  
Natural Products ◽  
Side Effects ◽  
Cancer Treatment ◽  
Broad Spectrum ◽  
Therapeutic Approach ◽  
Red Wine ◽  
Chemotherapeutic Drugs ◽  
Adverse Side Effects ◽  
Cancer Hallmarks ◽  
Anticancer Compound

There is a need to shift the paradigm of cancer therapeutic approach. The severe adverse side effects, drug resistanceand unaffordable price plagued with chemotherapeutic drugs has spurred the development of “dirty drug”. Natural products,specifically phytochemicals, have gained much attention due to their ability to target multiple interconnected pathways.Resveratrol (RSV), the stilbenes found in red wine, is one of the phytochemicals that exhibits various pharmacologicaltherapeutic effects including cancer. In this review, we highlighted RSV as a potential “broad-spectrum” anticancer compound,by summarising its targeting mechanisms in the pathways relevant to the cancer hallmarks.

scholarly journals Flavonoids in Cancer and Apoptosis

Cancers ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 28 ◽  
Author(s):  
Mariam Abotaleb ◽  
Samson Samuel ◽  
Elizabeth Varghese ◽  
Sharon Varghese ◽  
Peter Kubatka ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cost Effectiveness ◽  
Side Effects ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Adverse Side Effects ◽  
Highly Active ◽  
Major Interest ◽  
Anti Cancer ◽  
High Bioavailability

Cancer is the second leading cause of death globally. Although, there are many different approaches to cancer treatment, they are often painful due to adverse side effects and are sometimes ineffective due to increasing resistance to classical anti-cancer drugs or radiation therapy. Targeting delayed/inhibited apoptosis is a major approach in cancer treatment and a highly active area of research. Plant derived natural compounds are of major interest due to their high bioavailability, safety, minimal side effects and, most importantly, cost effectiveness. Flavonoids have gained importance as anti-cancer agents and have shown great potential as cytotoxic anti-cancer agents promoting apoptosis in cancer cells. In this review, a summary of flavonoids and their effectiveness in cancer treatment targeting apoptosis has been discussed.

scholarly journals Polymeric Nanoparticles: Exploring the Current Drug Development and Therapeutic Insight of Breast Cancer Treatment and Recommendations

Polymers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 4400
Author(s):  
Ali Sartaj ◽  
Zufika Qamar ◽  
Farheen Fatima Qizilbash ◽  
Annu ◽  
Shadab Md ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Side Effects ◽  
Cancer Treatment ◽  
Polymeric Nanoparticles ◽  
Breast Cancer Treatment ◽  
Chemotherapeutic Agents ◽  
First Line ◽  
Chemotherapy Drugs ◽  
Polymeric Nanoparticle

This manuscript aims to provide the latest update on polymeric nanoparticle drug delivery system for breast cancer treatment after 2015 and how research-oriented it is based on the available research data. Therefore, the authors have chosen breast cancer which is the most frequent and common reason for mortality in women worldwide. The first-line treatment for breast cancer treatment is chemotherapy, apart from surgery, radiation and hormonal therapy. Chemotherapy is associated with lesser therapeutics and undesirable side effects and hence. In addition, drug resistance affects the therapeutic dose to the target site. Although various nano-based formulations have been developed for effective treatment, the polymeric nanoparticles effectively avoid the lacunae of conventional chemotherapy. There has been an effort made to understand the chemotherapy drugs and their conventional formulation-related problems for better targeting and effective drug delivery for breast cancer treatment. Thus, the polymeric nanoparticles as a strategy overcome the associated problems with resulting dose reduction, enhanced bioavailability, reduced side effects, etc. This present review has compiled the research reports published from 2015 to 2021 from different databases, such as PubMed, Google Scholar, ScienceDirect, which are related to breast cancer treatment in which the drug delivery of numerous chemotherapeutic agents alone or in combination, including phytoconstituents formulated into various polymer-based nanoparticles.

Liposomes in Active, Passive and Acoustically-Triggered Drug Delivery

2019 ◽  
Vol 19 (12) ◽  
pp. 961-969 ◽  
Author(s):  
Sara Al Basha ◽  
Najla Salkho ◽  
Sarah Dalibalta ◽  
Ghaleb Adnan Husseini
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Noncommunicable Diseases ◽  
Chemotherapeutic Drugs ◽  
High Efficacy ◽  
Adverse Side Effects ◽  
Anticancer Drug Delivery ◽  
Selective Chemotherapy ◽  
Cancerous Cells ◽  
Shed Light

Cancer has become one of the most deadly noncommunicable diseases globally. Several modalities used to treat cancer patients exist today yet many have failed to prove high efficacy with low side effects. The most common example of such modalities is the use of chemotherapeutic drugs to treat cancerous cells and deter their uncontrolled proliferation. In addition to the destruction of cancerous tissues, chemotherapy destroys healthy tissues as it lacks the specificity to annihilate cancerous cells only and preferentially, which result in adverse side effects including nausea, hair fall and myocardial infarction. To prevent the side effects of non-selective chemotherapy, cancer therapy research has been focused on the implementation of nanocarrier systems that act as vehicles to encapsulate drugs and selectively transport their agent to the tumor site. In this paper, we shed light on liposomes along with three anticancer drug delivery approaches: passive, active and ultrasound-triggered drug delivery.

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