scholarly journals Resveratrol as a potential broad-spectrum compound for cancer treatment

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Li Kar Stella Tan ◽  
Chee Wun How ◽  
Jhi Biau Foo ◽  
Kooi Yeong Khaw ◽  
Bey Hing Goh ◽  
...  
Keyword(s):  
Natural Products ◽  
Side Effects ◽  
Cancer Treatment ◽  
Broad Spectrum ◽  
Therapeutic Approach ◽  
Red Wine ◽  
Chemotherapeutic Drugs ◽  
Adverse Side Effects ◽  
Cancer Hallmarks ◽  
Anticancer Compound

There is a need to shift the paradigm of cancer therapeutic approach. The severe adverse side effects, drug resistanceand unaffordable price plagued with chemotherapeutic drugs has spurred the development of “dirty drug”. Natural products,specifically phytochemicals, have gained much attention due to their ability to target multiple interconnected pathways.Resveratrol (RSV), the stilbenes found in red wine, is one of the phytochemicals that exhibits various pharmacologicaltherapeutic effects including cancer. In this review, we highlighted RSV as a potential “broad-spectrum” anticancer compound,by summarising its targeting mechanisms in the pathways relevant to the cancer hallmarks.

scholarly journals Parents are aware of the ototoxic effects of chemotherapy in paediatrics undergoing cancer treatment – Professional versus parental views: A pilot study

2017 ◽  
Vol 64 (1) ◽  
Author(s):  
Nomfundo F. Moroe ◽  
Kirstie Hughes
Keyword(s):  
Hearing Loss ◽  
Side Effects ◽  
Sampling Strategy ◽  
Public Hospitals ◽  
Chemotherapeutic Drugs ◽  
Chemotherapy Treatment ◽  
Adverse Side Effects ◽  
Number Of Children ◽  
Parental Views ◽  
Convenience Sampling

Background: The primary goal of chemotherapy is to cure cancer and its symptoms. Hence, in recent years, there has been an increase in cancer paediatric survival rate. However, there have also been adverse side effects such as ototoxic hearing loss because of chemotherapy. Therefore, this study aimed at exploring whether the parents of children undergoing chemotherapy are aware of ototoxic effects of chemotherapy.Methods: A non-experimental quantitative study was conducted to collect data through questionnaires, one for paediatric oncologists and the other for parents. A convenience sampling strategy was employed to recruit 11 paediatric oncologists and 7 parents from two public hospitals in Gauteng. The questionnaires were analysed quantitatively, using descriptive statistics.Results: About 55% of paediatric oncologists indicated informing parents about the ototoxic effects of chemotherapy. On the contrary, 71% of parents reported having been informed by paediatric oncologists about the possible hearing loss because of chemotherapy; however, 57% of the children are receiving a combination of cisplatin and cyclophosphamide despite being aware of their ototoxic nature.Conclusion: This study paves the way for qualitative studies to ascertain how parents are informed about the possible side effects such as hearing loss because of chemotherapy treatment. The mode in which parents are informed about the possible side effects related to chemotherapy is critical, considering that a high number of children are still receiving chemotherapeutic drugs that are directly linked to hearing loss.

scholarly journals Flowers for cancer treatment: From beauty to duty

TAYACAJA ◽  
2021 ◽  
Vol 4 (1) ◽  
pp. 193-202
Author(s):  
Jorge L. Gutierrez-Pajares ◽  
Amr Abdelkhalek
Keyword(s):  
Side Effects ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Chemotherapeutic Drugs ◽  
Target Cancer

Cancer is a worldwide disease that affects millions of people every year. Although there are several approved chemotherapeutic drugs for cancer treatment, there is s constant search for new molecules. This search is supported by the need of new molecules that could target cancer cells specifically reducing side effects or that could act synergistically with approved anticancer drugs. In this review, research on flower extracts and flower-derived molecules is presented.

scholarly journals Flavonoids in Cancer and Apoptosis

Cancers ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 28 ◽  
Author(s):  
Mariam Abotaleb ◽  
Samson Samuel ◽  
Elizabeth Varghese ◽  
Sharon Varghese ◽  
Peter Kubatka ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cost Effectiveness ◽  
Side Effects ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Adverse Side Effects ◽  
Highly Active ◽  
Major Interest ◽  
Anti Cancer ◽  
High Bioavailability

Cancer is the second leading cause of death globally. Although, there are many different approaches to cancer treatment, they are often painful due to adverse side effects and are sometimes ineffective due to increasing resistance to classical anti-cancer drugs or radiation therapy. Targeting delayed/inhibited apoptosis is a major approach in cancer treatment and a highly active area of research. Plant derived natural compounds are of major interest due to their high bioavailability, safety, minimal side effects and, most importantly, cost effectiveness. Flavonoids have gained importance as anti-cancer agents and have shown great potential as cytotoxic anti-cancer agents promoting apoptosis in cancer cells. In this review, a summary of flavonoids and their effectiveness in cancer treatment targeting apoptosis has been discussed.

Liposomes in Active, Passive and Acoustically-Triggered Drug Delivery

2019 ◽  
Vol 19 (12) ◽  
pp. 961-969 ◽  
Author(s):  
Sara Al Basha ◽  
Najla Salkho ◽  
Sarah Dalibalta ◽  
Ghaleb Adnan Husseini
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Noncommunicable Diseases ◽  
Chemotherapeutic Drugs ◽  
High Efficacy ◽  
Adverse Side Effects ◽  
Anticancer Drug Delivery ◽  
Selective Chemotherapy ◽  
Cancerous Cells ◽  
Shed Light

Cancer has become one of the most deadly noncommunicable diseases globally. Several modalities used to treat cancer patients exist today yet many have failed to prove high efficacy with low side effects. The most common example of such modalities is the use of chemotherapeutic drugs to treat cancerous cells and deter their uncontrolled proliferation. In addition to the destruction of cancerous tissues, chemotherapy destroys healthy tissues as it lacks the specificity to annihilate cancerous cells only and preferentially, which result in adverse side effects including nausea, hair fall and myocardial infarction. To prevent the side effects of non-selective chemotherapy, cancer therapy research has been focused on the implementation of nanocarrier systems that act as vehicles to encapsulate drugs and selectively transport their agent to the tumor site. In this paper, we shed light on liposomes along with three anticancer drug delivery approaches: passive, active and ultrasound-triggered drug delivery.

Communication about immunotherapy: Barriers and information to discuss.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 6543-6543
Author(s):  
Kristen Gillespy ◽  
Margie D Dixon ◽  
Rebecca D. Pentz
Keyword(s):  
Side Effects ◽  
Cancer Treatment ◽  
Patient Preferences ◽  
Therapeutic Approach ◽  
Treatment Options ◽  
Patient Communication ◽  
Physician Patient Communication ◽  
Realistic View ◽  
Positive Impression ◽  
Physician Patient

6543 Background: Since immunotherapy is a promising new therapeutic approach to cancer treatment, improving physician/patient communication about this approach is important. No communication guidelines exist. To begin to fill this gap, we identified provider and patient preferences for information, and identified barriers to communication about immunotherapy. Methods: We qualitatively interviewed 15 oncology professionals who offer immunotherapy treatment about the information they deemed important to communicate to patients and the communication barriers. After a discussion about immunotherapy options with a provider, we interviewed 18 oncology patients about the information that was most useful to them and their impressions of immunotherapy. We captured impressions on two 1-5 scales with 5 being ‘very positive impression’ and ‘very likely to be cured’ and by picking words from a list of positive and negative terms like ‘effective’ and ‘risky.’ All open-ended questions were qualitatively coded. We reached saturation of themes with 18 patients. Results: Patients identified 4 useful topics to discuss: treatment options, benefits, treatment logistics, and side effects. Providers identified 3 topics important topics to convey: side effects, realistic view of benefit and treatment logistics. The most frequently provider-identified barrier to communication was patients’ baseline misconceptions about immunotherapy’s effectiveness. Supporting this, patients’ impressions were very positive (average of 4 on impressions scale and 3.9 on potential to be cured scale.) The most frequently chosen word patients chose to describe immunotherapy treatment was ‘hopeful’ (10/18 55%). Conclusions: There is largely agreement on the important topics to discuss about immunotherapy, though half of the patients thought a discussion of treatment options would be useful and only one physicians mentioned options. Of note, communication is hampered by patients’ preconceptions about immunotherapy’s effectiveness. Communication guidelines should identify techniques to effectively overcome this barrier.

A Comprehensive Review of the Use of Antioxidants and Natural Products in Cancer Patients Receiving Anticancer Therapy

2021 ◽  
Vol 21 ◽  
Author(s):  
Daniel Sur ◽  
Alecsandra Gorzo ◽  
Shanthi Sabarimurugan ◽  
Saravana Murali Krishnan ◽  
Cristian Virgil Lungulescu ◽  
...  
Keyword(s):  
Natural Products ◽  
Side Effects ◽  
Cancer Treatment ◽  
Dietary Supplements ◽  
Cancer Patients ◽  
Clinical Studies ◽  
Well Being ◽  
Mortality And Morbidity ◽  
Dietary Antioxidant ◽  
Antioxidant Supplements

: Cancer is the leading cause of mortality and morbidity worldwide. The side effects of cancer treatment affect the quality of life. Cancer patients search for antioxidant dietary supplements and natural products during or after conventional cancer treatment for the alleviation of side effects, improvement of the benefits of treatment, and promotion of well-being. However, the efficacy and safety of these products remain controversial; moreover, previous data do not support the standardized use of those alternative treatments in clinics. The current study reviewed the manuscripts reporting the administration of antioxidants and natural products during cancer treatment and revised preclinical and clinical studies on various types of cancer. Most of the positive results were obtained from experimental animal models; however, human clinical studies are discouraging in this regard. Therefore, further precise and distinguishable studies are required regarding antioxidant dietary supplementation. Future studies are also needed to clarify dietary supplements’ mechanism of action and pharmacokinetics in a suitable cancer patient population that will benefit the therapeutic regimens. Despite the popularity of dietary supplements, clinicians and patients should always consider their potential benefits and risks. Patients should discuss with their physician before taking any dietary antioxidant supplements or natural products.

scholarly journals Cytotoxic and Antimicrobial Activities of Quinones Isolated from Different Organism

2021 ◽  
Author(s):  
Nimsi Campos-Xolalpa ◽  
Julia Pérez-Ramos ◽  
Ana Esquivel-Campos ◽  
Cuauhtemoc Pérez-González ◽  
Leonor Sánchez-Pérez ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Natural Products ◽  
Side Effects ◽  
Cell Growth ◽  
Secondary Metabolites ◽  
Cancer Treatment ◽  
Antimicrobial Activities ◽  
Therapeutic Strategies ◽  
Incidence And Mortality ◽  
New Compounds

Cancer is a group of related diseases in which there is uncontrolled cell growth that spreads to the surrounding tissues and damages them. Cancer remains the disease with the leading cause of death worldwide, and incidence and mortality are increasing rapidly. The main cancer treatment is chemotherapy; however, the compounds used in this treatment have serious side effects for this reason, is necessary to develop new therapeutic strategies. Natural products are an excellent pharmacological alternative for the treatment of cancer and infections. In search of new compounds with cytotoxic and antimicrobial activity, we have found quinones that have a high pharmacological potency in the treatment of these health problems. Quinones are an aromatic system of one or diketone and are mainly isolated from plants, fungi, bacteria, and other organisms. These compounds are secondary metabolites derived from the oxidation of hydroquinones; they include benzoquinones, naphthoquinones, anthraquinones, and polyquinones. This review summarizes the activity of 152 anticancer and 30 antimicrobial quinones.

Prodrug-Based Self-Assembled Nanoparticles Formed by 3′,5′-Dioleoyl Floxuridine for Cancer Chemotherapy

2021 ◽  
Author(s):  
Hui Xu ◽  
Yue Xiao ◽  
Jinlu Tang ◽  
Dongfang Liu ◽  
Xinxin Shi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Treatment ◽  
Cancer Chemotherapy ◽  
Adverse Side Effects ◽  
Self Assembled

Chemotherapy for cancer treatment is wildly used but remain restricted by several limitations, including inefficient drug delivery and concomitant adverse side effects. Herein, we reported a new prodrug-based self-assembled nanoparticle...

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