Self-assembled micelles of PEG–poly(disulfide carbamate amine) copolymers for intracellular dual-responsive drug delivery

2016 ◽  
Vol 4 (5) ◽  
pp. 902-909 ◽  
Author(s):  
Chao Lin ◽  
Bo Lou ◽  
Jie Zhao ◽  
Rong Jin ◽  
Peng Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Chemotherapy ◽  
Dual Responsive ◽  
Biodegradable Poly ◽  
Self Assembled

Self-assembled nanomicelles based on biodegradable poly(carbamate) copolymers are applicable for pH and redox dual-responsive release of doxorubicin (Dox) and cancer chemotherapy.

“Smart” self-assembled structures: toward intelligent dual responsive drug delivery systems

2020 ◽  
Vol 8 (21) ◽  
pp. 5787-5803
Author(s):  
Mahsa Shahriari ◽  
Vladimir P. Torchilin ◽  
Seyed Mohammad Taghdisi ◽  
Khalil Abnous ◽  
Mohammad Ramezani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Dual Responsive ◽  
Current Review ◽  
Self Assembled ◽  
Novel Structures

In the current review, we summarized the polymer and peptide-based schizophrenic copolymers which could form micellar and vesicular (polymersome) systems providing novel structures with beneficial applications.

Injectable pH and redox dual responsive hydrogels based on self-assembled peptides for anti-tumor drug delivery

2020 ◽  
Vol 8 (19) ◽  
pp. 5415-5426
Author(s):  
Ying Zhu ◽  
Liying Wang ◽  
Yiping Li ◽  
Zhewei Huang ◽  
Shiyao Luo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antitumor Drugs ◽  
Dual Responsive ◽  
Tumor Drug Delivery ◽  
Self Assembled ◽  
Peptide Hydrogels ◽  
Responsive Hydrogels

Dual responsive and injectable peptide hydrogels that form gels in vitro control the release of antitumor drugs in vivo.

scholarly journals Self-Assembled Redox Dual-Responsive Prodrug-Nanosystem Formed by Single Thioether-Bridged Paclitaxel-Fatty Acid Conjugate for Cancer Chemotherapy

Nano Letters ◽  
2016 ◽  
Vol 16 (9) ◽  
pp. 5401-5408 ◽  
Author(s):  
Cong Luo ◽  
Jin Sun ◽  
Dan Liu ◽  
Bingjun Sun ◽  
Lei Miao ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cancer Chemotherapy ◽  
Dual Responsive ◽  
Acid Conjugate ◽  
Self Assembled

Thermally self-assembled biodegradable poly(casein-g-N-isopropylacrylamide) unimers and their application in drug delivery for cancer therapy

2020 ◽  
Vol 154 ◽  
pp. 446-455
Author(s):  
Julio C. Cuggino ◽  
Franco E. Ambrosioni ◽  
Matías L. Picchio ◽  
Maribel Nicola ◽  
Álvaro F. Jiménez Kairuz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Biodegradable Poly ◽  
Self Assembled

Prodrug-Based Self-Assembled Nanoparticles Formed by 3′,5′-Dioleoyl Floxuridine for Cancer Chemotherapy

2021 ◽  
Author(s):  
Hui Xu ◽  
Yue Xiao ◽  
Jinlu Tang ◽  
Dongfang Liu ◽  
Xinxin Shi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Treatment ◽  
Cancer Chemotherapy ◽  
Adverse Side Effects ◽  
Self Assembled

Chemotherapy for cancer treatment is wildly used but remain restricted by several limitations, including inefficient drug delivery and concomitant adverse side effects. Herein, we reported a new prodrug-based self-assembled nanoparticle...

scholarly journals Loading and release of cancer chemotherapy drugs utilizing simultaneous temperature and pH-responsive nanohybrid

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Mohammad Dahri ◽  
Hossein Akbarialiabad ◽  
Ahmad Miri Jahromi ◽  
Reza Maleki
Keyword(s):  
Drug Delivery ◽  
Cancer Chemotherapy ◽  
Degradation Mechanism ◽  
Biochemical Properties ◽  
Release Mechanism ◽  
Chemotherapy Drugs ◽  
Drug Delivery Carrier ◽  
Dual Responsive ◽  
Walled Carbon Nanotubes ◽  
Chemotherapy Agents

Abstract Background Recently, the development of nanocarriers and the improvement of their biochemical properties have became of great importance. Single-walled carbon nanotubes (SWCNT) have many applications in drug delivery systems (DDS) as a common carbon-based structure. In the current work, the penetration, co-loading, and co-release of Doxorubicin (DOX) and Paclitaxel (PAX), as two cancer chemotherapy agents, were investigated using a novel modified copolymer with functionalized SWCNT. Results This study proposes a dual-responsive smart carrier that is sensitive to pH and temperature. The carrier consists of functionalized SWNT and Dimethyl acrylamide-trimethyl chitosan (DMAA-TMC) grafting on SWCNT. This suggested carrier was investigated by utilizing molecular simulations. Interaction energies between DOX, PAX, and carrier as well as the affinity of drugs to the nanocarrier were studied. The energy analysis of drug release and adsorption presented that DOX and PAX delivery using this carrier is selective and sensitive at healthy and cancerous conditions. The attraction of DMAA-TMC, as a biodegradable and biocompatible copolymer, with SWCNT showed that degradation mechanism in acidic environment deformed the copolymer. This leads to a smart release mechanism in an acidic cancerous tissue. Additionally, it improves hydrophilicity, optimum nano-particle size, and cell cytotoxicity concerns. Conclusions The simulation results manifested a significant contribution of DMAA-TMC in the adsorption and release of cancer chemotherapy drugs in normal and neoplastic tissues. The interaction of copolymer also improves the biocompatibility and biodegradability of the SWCNT. Smart drug delivery carrier can be a valuable nanohybrid for loading, transporting, and releasing of cancer chemotherapy drugs. Graphical abstract

Sign in / Sign up

Export Citation Format

Share Document