scholarly journals Porous Hydrogen-Bonded Organic Frameworks Membrane for High-Performance Molecular Separation

2021 ◽  
Author(s):  
Xiao-Tian Jiang ◽  
qi Yin ◽  
Bai-tong Liu ◽  
Jun-Yu Chen ◽  
Rui Wang ◽  
...  
Keyword(s):  
High Performance ◽  
Promising Candidate ◽  
Molecular Separation ◽  
Hydrogen Bonded

Hydrogen-bonded organic frameworks (HOFs) with intrinsic, tunable, and uniform pores are promising candidate of membrane for molecular separation but have yet to be explored in this filed. Herein, a type...

Pharmacokinetics and Tissue Distribution Study of Ferruginol in Wistar Rat by High-performance Liquid Chromatography

2018 ◽  
Vol 15 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Guiyun Cao ◽  
Suqiao Han ◽  
Keke Li ◽  
Li Shen ◽  
Xiaohong Wang ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Mobile Phase ◽  
High Performance ◽  
Wistar Rat ◽  
Freezing And Thawing ◽  
Promising Candidate ◽  
Distribution Study ◽  
Substance Loss ◽  
Tissue Distribution Study ◽  
The Brain

Background: Ferruginol (FRGN) exhibits a broad range of pharmacological properties which make it a promising candidate for chemoprevention. However, little is known about its absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties. Methods: A rapid, sensitive and specific HPLC-DAD method was established to quantify FRGN in the plasma and tissues of Wistar rats. After extraction of FRGN with ethyl acetate (EtOAc), chromatographic separation was performed on a YMC ODS C18 column (250 × 4.6 mm I.D., 5 µm) with a mobile phase consisting of methanol-water (92:8, v/v) at a flow rate of 0.9 mL/min. Detection was conducted with a wavelength of 273 nm at 25 °C. Results: The calibration curves for FRGN were linear in the concentration range of 0.5-20 µg/mL for plasma, 0.5-10 µg/mL for heart, liver, spleen, lung, kidney, stomach, intestine, brain and muscle. After three cycles of freezing and thawing, the concentration variations were within ± 7% of nominal concentrations, indicating no significant substance loss during repeated thawing and freezing. The assay was applied to pharmacokinetic and tissue distribution study in rats. Results suggested that lung, heart, liver, spleen and kidney were the major distribution tissues of FRGN in rats, and FRGN could permeate the blood-brain barrier to distribute in the brain of rats. Conclusion: The information provided by this research is very useful for gaining knowledge of the pharmacokinetic process and tissue distribution of FRGN.

scholarly journals Loxosceles gaucho Spider Venom: An Untapped Source of Antimicrobial Agents

Toxins ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 522 ◽  
Author(s):  
Paula Segura-Ramírez ◽  
Pedro Silva Júnior
Keyword(s):  
Bacterial Infections ◽  
High Performance ◽  
Antimicrobial Agents ◽  
Chemical Properties ◽  
Carcinoma Cells ◽  
Promising Candidate ◽  
Human Red Blood Cells ◽  
New Antibiotics ◽  
Conventional Antibiotics ◽  
Human Cervical Carcinoma Cells

The remarkable ability of microorganisms to develop resistance to conventional antibiotics is one of the biggest challenges that the pharmaceutical industry currently faces. Recent studies suggest that antimicrobial peptides discovered in spider venoms may be useful resources for the design of structurally new anti-infective agents effective against drug-resistant microorganisms. In this work, we found an anionic antibacterial peptide named U1-SCRTX-Lg1a in the venom of the spider Loxosceles gaucho. The peptide was purified using high-performance liquid chromatography (HPLC), its antimicrobial activity was tested through liquid growth inhibition assays, and its chemical properties were characterized using mass spectrometry. U1-SCRTX-Lg1a was found to show a monoisotopic mass of 1695.75 Da, activity against Gram-negative bacteria, a lack of hemolytic effects against human red blood cells, and a lack of cytotoxicity against human cervical carcinoma cells (HeLa). Besides this, the sequence of the peptide exhibited great similarity to specific regions of phospholipases D from different species of Loxosceles spiders, leading to the hypothesis that U1-SCRTX-Lg1a may have originated from a limited proteolytic cleavage. Our data suggest that U1-SCRTX-Lg1a is a promising candidate for the development of new antibiotics that could help fight bacterial infections and represents an exciting discovery for Loxosceles spiders.

scholarly journals Interlayer Hydrogen-Bonded Covalent Organic Frameworks as High-Performance Supercapacitors

2018 ◽  
Vol 140 (35) ◽  
pp. 10941-10945 ◽  
Author(s):  
Arjun Halder ◽  
Meena Ghosh ◽  
Abdul Khayum M ◽  
Saibal Bera ◽  
Matthew Addicoat ◽  
...  
Keyword(s):  
High Performance ◽  
Covalent Organic Frameworks ◽  
Hydrogen Bonded

scholarly journals Bioinspired nano-ordered liquid membrane for precise molecular separation

2020 ◽  
Author(s):  
Haozhen Dou ◽  
Mi Xu ◽  
Baoyu Wang ◽  
Zhen Zhang ◽  
Guobin Wen ◽  
...  
Keyword(s):  
Self Assembly ◽  
High Performance ◽  
Liquid Membrane ◽  
Three Dimensional ◽  
Cellular Membrane ◽  
Liquid Structure ◽  
Long Term Stability ◽  
Separation Membranes ◽  
Molecular Separation

Abstract Cellular membranes provide ideal archetypes for molecule or ion separations with sub-angstrom scale precision, which are featured with both extremely high permeability and selectivity due to the well-defined membrane protein channels. However, the development of bioinspired membranes with artificial channels for sub-angstrom scale ethylene/ethane (0.416 nm / 0.443 nm) separation remains an uncharted territory and a significant challenge. Herein, a bioinspired nano-ordered liquid membrane is constructed by a facile ion/molecule self-assembly strategy for highly efficient ethylene/ethane separation, which mimics the structure of cellular membrane elegantly and possesses plenty of three-dimensional (3D) nanochannels. The elaborate regulation of non-covalent interactions by optimizing the ion/molecule compositions within membrane confers the nano-ordered liquid structure with interpenetrating and bi-continuous apolar domains and polar domains, which results in the formation of regular carrier wires and enormous 3D interconnected ethylene transport nanochannels. By virtue of these 3D nanochannels, the bioinspired nano-ordered liquid membrane manifests simultaneously super-high selectivity, excellent permeance and long-term stability, which exceeds previously reported ethylene/ethane separation membranes. This methodology in this work for construction of bioinspired membrane with tunable 3D nanochannels through ion/molecule self-assembly will enlighten the design and development of high-performance separation membranes for angstrom/sub-angstrom scale ion or molecule separations.

Two-dimensional GeSe for high performance thin-film solar cells

2018 ◽  
Vol 6 (12) ◽  
pp. 5032-5039 ◽  
Author(s):  
Xingshuai Lv ◽  
Wei Wei ◽  
Cong Mu ◽  
Baibiao Huang ◽  
Ying Dai
Keyword(s):  
Thin Film ◽  
Solar Cells ◽  
Schottky Barrier ◽  
High Performance ◽  
Thin Film Solar Cells ◽  
Two Dimensional ◽  
Photovoltaic Devices ◽  
Promising Candidate

Multilayer GeSe can be a promising candidate for flexible photovoltaic devices because of the low Schottky barrier at the back electrode and high PCE of ∼18%.

Ultra-thin Polymer Electrolyte Based on Single-Helical-Structured Agarose for High Performance Solid-state Lithium Batteries

2021 ◽  
Author(s):  
Xingzhao Zhang ◽  
Ying Chu ◽  
Ximing Cui ◽  
Yuxuan Li ◽  
Qinmin Pan
Keyword(s):  
Solid State ◽  
Polymer Electrolyte ◽  
Lithium Batteries ◽  
High Performance ◽  
Solid Polymer Electrolyte ◽  
Lithium Battery ◽  
Storage Systems ◽  
Solid Polymer ◽  
Promising Candidate ◽  
Thin Polymer

Solid-state lithium battery is considered as a promising candidate for next-generation energy storage systems because of its high safety and energy density. Solid polymer electrolyte is a paramount component in...

Suppressed Distortion Performance Metrics of 20nm GAA-GaN/Al2O3 Nanowire MOSFET: Based on Quantum Numerical Simulation 

2021 ◽  
Author(s):  
Neha Gupta ◽  
Aditya Jain ◽  
Ajay Kumar
Keyword(s):  
High Performance ◽  
Room Temperature ◽  
Performance Metrics ◽  
Crossover Point ◽  
Promising Candidate ◽  
Higher Derivatives ◽  
Low Distortion ◽  
Simulation Results ◽  
Intercept Point ◽  
Nanowire Mosfet

Abstract This work investigates the suppressed distortion performance metrics of gate all around (GAA) Gallium Nitride (GaN)/Al2O3 Nanowire (NW) n-channel MOSFET (GaNNW/Al2O3 MOSFET) based on quantum numerical simulations at room temperature (300 K). The simulation results show high switching ratio (≈109) with low subthreshold swing (67mV/decade), high QF value (4.1mS-decade/mV) of GaNNW/Al2O3-MOSFET in comparison to GaNNW/SiO2 and SiNW MOSFET for Vds=0.4V due to the lower permittivity of GaN and more effective mass of the electron. Furthermore, linearity and distortion performance is also examined by numerically calculating transconductance and its higher derivatives (gm2 and gm3); voltage and current intercept point (VIP2, VIP3 and IIP3); 1-dB compression point; Harmonics distortions (HD2 and HD3) and IMD3. All these parameters show high linearity and low distortion at zero crossover point (where gm3=0) in GaNNW/Al2O3 MOSFET. Thus, GaNNW MOSFET can be considered as a promising candidate for low power high-performance applications. In addition, effect of ambient temperature (250K-450K) on the performance of GaNNW/Al2O3 is studied and discussed in terms of the above mentioned metrics. It is very well exhibited that SS, Ion, Vth, and QF improved when the temperature is lowered which makes it suitable for low-temperature environments. But, linearity degrades as the temperature lowers down.

Plasmon-enhanced high-performance Si-based light sources by incorporating alloyed Au and Ag nanorods

CrystEngComm ◽  
2020 ◽  
Vol 22 (37) ◽  
pp. 6106-6115 ◽  
Author(s):  
Yang Liu ◽  
Mingming Jiang ◽  
Kai Tang ◽  
Kunjie Ma ◽  
Yuting Wu ◽  
...  
Keyword(s):  
High Performance ◽  
High Efficiency ◽  
Light Sources ◽  
Promising Candidate

Benefitting from alloyed Au and Ag nanorods with desired plasmons, single ZnO:Ga microwire assembled on a p-Si template, can provide a promising candidate for the realization of high-efficiency Si-based light sources

High-performance red electrophosphorescent devices based on all-solution-processed hydrogen-bonded supramolecular material

2018 ◽  
Vol 6 (15) ◽  
pp. 4095-4105 ◽  
Author(s):  
Cheng Zhang ◽  
Hui Zeng ◽  
Qingyu Huang ◽  
Yi Wang ◽  
Yongshuai Chai ◽  
...  
Keyword(s):  
High Performance ◽  
Solution Processed ◽  
Supramolecular Material ◽  
Hydrogen Bonded

All-solution-processed, high-performance red phosphorescent OLED developed from hydrogen-bonded supramolecular material.

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