Strong underwater adhesion of injectable hydrogels triggered by diffusion of small molecules

2021 ◽  
Author(s):  
Xing Su ◽  
Wenyue Xie ◽  
Pudi Wang ◽  
Zhuoling Tian ◽  
Hao Wang ◽  
...  
Keyword(s):  
Small Molecules ◽  
Tea Polyphenols ◽  
Injectable Hydrogels ◽  
Injectable Hydrogel ◽  
Underwater Adhesion ◽  
Physically Crosslinked

It is challenging for injectable hydrogels to achieve high underwater adhesiveness. Based on this concern, we report a fully physically crosslinked injectable hydrogel composed of gelatin, tea polyphenols and urea,...

Physically crosslinked injectable hydrogels for long-term delivery of oncolytic adenoviruses for cancer treatment

2019 ◽  
Vol 7 (10) ◽  
pp. 4195-4207 ◽  
Author(s):  
Thai Minh Duy Le ◽  
Bo-Kyeong Jung ◽  
Yi Li ◽  
Huu Thuy Trang Duong ◽  
Thanh Loc Nguyen ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Injectable Hydrogels ◽  
Injectable Hydrogel ◽  
Temperature Responsive ◽  
Oncolytic Adenoviruses ◽  
Term Delivery ◽  
Physically Crosslinked ◽  
Hydrogel System

A dual pH- and temperature-responsive physically crosslinked and injectable hydrogel system was developed for efficient and long-term delivery of oncolytic adenoviruses (Ads).

A catechol-chitosan-based adhesive and injectable hydrogel resistant to oxidation and compatible with cell therapy

2021 ◽  
Author(s):  
Capucine Guyot ◽  
Atma Adoungotchodo ◽  
Werner Taillades ◽  
Marta Cerruti ◽  
Sophie Lerouge
Keyword(s):  
Cell Therapy ◽  
Injectable Hydrogels ◽  
Injectable Hydrogel ◽  
Encapsulated Cells

Injectable hydrogels designed for cell therapy need to be adhesive to the surrounding tissues to maximize their retention and the communication between the host and the encapsulated cells. Catechol grafting...

scholarly journals Recent Advances in Injectable Hydrogels for Biomedical Applications

2019 ◽  
Vol 2 (1) ◽  
pp. 1 ◽  
Author(s):  
Eko Adi Prasetyanto
Keyword(s):  
Tissue Engineering ◽  
Biomedical Applications ◽  
State Of The Art ◽  
Research Progress ◽  
Hybrid Hydrogel ◽  
Injectable Hydrogels ◽  
Injectable Hydrogel ◽  
Different Types ◽  
And Cartilage ◽  
Recent Research Progress

Injectable hydrogels, a class of hydrogel, have received a lot of attention in biomedical applications due to its versatility. It is reported that injectable hydrogel can be applied in various biomedical procedures for example as submucosal fluid cushion, periodontal implant, and cartilage and bone tissue engineering. In addition to its easy delivery (implantation), this class of hydrogel can be tailored to match specific applications. The customization of this hydrogel can be easily executed by changing polymeric backbone of hydrogel, choosing different types of crosslinking or by adding nanoparticles to form hybrid hydrogel systems. Physical properties, compatibility and biodegradability of the resulted materials are important factors for designing injectable hydrogels. In this Recent Research Progress, we highlight the state-of-the-art injectable hydrogels and note the general requirements of an ideal injectable hydrogel for biomedical applications.

scholarly journals Injectable hydrogels self-assembled from oligopeptide-poly(2-methacryloyloxyethyl phosphorylcholine) hybrid graft copolymers for cell scaffolds and controlled release applications

2021 ◽  
Author(s):  
Tomoyuki Koga ◽  
Tomoo Matsuoka ◽  
Yusuke Morita ◽  
Nobuyuki Higashi
Keyword(s):  
Controlled Release ◽  
Graft Copolymers ◽  
Injectable Hydrogels ◽  
Injectable Hydrogel ◽  
Self Assembling ◽  
Cell Scaffolds ◽  
Self Assembled

An injectable hydrogel composed of biocompatible PMPC with PEG-attached self-assembling peptide grafts was newly prepared, and it could be used as 3D cell scaffolds and controlled-release applications.

scholarly journals Regeneration of Articular Cartilage Using Injectable Hybrid Polymer Hydrogel Incorporated With Nanoparticles

2021 ◽  
pp. 394-397
Author(s):  
T. Ruhina ◽  
N. Mahdhia Begum ◽  
S. Padmavathi ◽  
I. Sahanajith ◽  
K. Karthick Babu
Keyword(s):  
Articular Cartilage ◽  
Cartilage Repair ◽  
Cartilage Damage ◽  
Cartilage Tissue Engineering ◽  
Treatment Strategies ◽  
Bioactive Molecules ◽  
Cartilage Tissue ◽  
Human Beings ◽  
Injectable Hydrogels ◽  
Injectable Hydrogel

Cartilage damage is still a threat to human beings, yet there is currently no treatment available to fully restore the function of cartilage. Recently, due to their unique structures and properties, injectable hydrogels have been widely studied and have exhibited high potential for applications in therapeutic areas, especially in cartilage repair. In this review, briefly introduce the properties of cartilage, some articular cartilage injuries, and now available treatment strategies. Afterwards,the functional and fundamental requirements of injectable hydrogels in cartilage tissue engineering, as well as the main advantages of injectable hydrogels as a therapy for cartilage damage, including strong plasticity and excellent biocompatibility. Moreover, we comprehensively summarize the polymers, cells, and bioactive molecules regularly used in the fabrication of injectable hydrogel, with two kinds of gelation, i.e., physical and chemical crosslinking, which ensure the excellence design of injectable hydrogels for cartilage repair. We also include the novel hybrid injectable hydrogel incorporated with nanoparticles. Finally, we conclude with the advances of this clinical application and the challenges of injectable hydrogels used in cartilage.

scholarly journals Recombinant Human Bone Morphogenic Protein-2 Immobilized Fabrication of Magnesium Functionalized Injectable Hydrogels for Controlled-Delivery and Osteogenic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells in Femoral Head Necrosis Repair

2021 ◽  
Vol 9 ◽  
Author(s):  
Xueliang Lu ◽  
Hongyu Guo ◽  
Jiaju Li ◽  
Tianyu Sun ◽  
Mingyue Xiong
Keyword(s):  
Bone Marrow ◽  
Osteogenic Differentiation ◽  
Controlled Delivery ◽  
Cross Linking ◽  
Injectable Hydrogels ◽  
Injectable Hydrogel ◽  
Cell Carriers ◽  
Bone Morphogenic Protein 2 ◽  
Recombinant Human Bone ◽  
Rat Bone

Femoral head necrosis (FHN) is a clinically progressive disease that leads to overwhelming complications without an effective therapeutic approach. In recent decades, transplantation of mesenchymal stem cells (MSCs) has played a promising role in the treatment of FHN in the initial stage; however, the success rate is still low because of unsuitable cell carriers and abridged osteogenic differentiation of the transplanted MSCs. Biopolymeric-derived hydrogels have been extensively applied as effective cell carriers and drug vesicles; they provide the most promising contributions in the fields of tissue engineering and regenerative medicine. However, the clinical potential of hydrogels may be limited because of inappropriate gelation, swelling, mechanical characteristics, toxicity in the cross-linking process, and self-healing ability. Naturally, gelated commercial hydrogels are not suitable for cell injection and infiltration because of their static network structure. In this study, we designed a novel thermogelling injectable hydrogel using natural silk fibroin-blended chitosan (CS) incorporated with magnesium (Mg) substitutes to improve physical cross-linking, stability, and cell osteogenic compatibility. The presented observations demonstrate that the developed injectable hydrogels can facilitate the controlled delivery of immobilized recombinant human bone morphogenic protein-2 (rhBMP-2) and rat bone marrow-derived MSCs (rBMSCs) with greater cell encapsulation efficiency, compatibility, and osteogenic differentiation. In addition, outcomes of in vivo animal studies established promising osteoinductive, bone mineral density, and bone formation rate after implantation of the injectable hydrogel scaffolds. Therefore, the developed hydrogels have great potential for clinical applications of FHN therapy.

Carrageenan-based physically crosslinked injectable hydrogel for wound healing and tissue repairing applications

2020 ◽  
Vol 589 ◽  
pp. 119828
Author(s):  
Natalia Pettinelli ◽  
Saddys Rodríguez-Llamazares ◽  
Rebeca Bouza ◽  
Luis Barral ◽  
Sandra Feijoo-Bandín ◽  
...  
Keyword(s):  
Wound Healing ◽  
Injectable Hydrogel ◽  
Physically Crosslinked

scholarly journals Delivery of interleukin-10 via injectable hydrogels improves renal outcomes and reduces systemic inflammation following ischemic acute kidney injury in mice

2016 ◽  
Vol 311 (2) ◽  
pp. F362-F372 ◽  
Author(s):  
Danielle E. Soranno ◽  
Christopher B. Rodell ◽  
Christopher Altmann ◽  
Jane Duplantis ◽  
Ana Andres-Hernando ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Systemic Inflammation ◽  
Collagen Type ◽  
Left Kidney ◽  
Kidney Injury ◽  
Interleukin 10 ◽  
Collagen Type Iii ◽  
Injectable Hydrogels ◽  
Injectable Hydrogel ◽  
Kidney Capsule

Injectable hydrogels can be used to deliver drugs in situ over a sustained period of time. We hypothesized that sustained delivery of interleukin-10 (IL-10) following acute kidney injury (AKI) would mitigate the local and systemic proinflammatory cascade induced by AKI and reduce subsequent fibrosis. Wild-type C57BL/6 mice underwent ischemia-reperfusion AKI with avertin anesthesia. Three days later, mice were treated with either hyaluronic acid injectable hydrogel with or without IL-10, or IL-10 suspended in saline, injected under the capsule of the left kidney, or hydrogel with IL-10 injected subcutaneously. Untreated AKI served as controls. Serial in vivo optical imaging tracked the location and degradation of the hydrogel over time. Kidney function was assessed serially. Animals were killed 28 days following AKI and the following were evaluated: serum IL-6, lung inflammation, urine neutrophil gelatinase-associated lipocalin, and renal histology for fibroblast activity, collagen type III deposition and fibrosis via Picrosirius Red staining and second harmonic imaging. Our model shows persistent systemic inflammation, and renal inflammation and fibrosis 28 days following AKI. The hydrogels are biocompatible and reduced serum IL-6 and renal collagen type III 28 days following AKI even when delivered without IL-10. Treatment with IL-10 reduced renal and systemic inflammation, regardless of whether the IL-10 was delivered in a sustained manner via the injectable hydrogel under the left kidney capsule, as a bolus injection via saline under the left kidney capsule, or via the injectable hydrogel subcutaneously. Injectable hydrogels are suitable for local drug delivery following renal injury, are biocompatible, and help mitigate local and systemic inflammation.

Fabrication of an injectable hydrogel with inherent photothermal effects from tannic acid for synergistic photothermal-chemotherapy

2021 ◽  
Author(s):  
Xiao Zhu ◽  
Binggang Guan ◽  
Ziling Sun ◽  
Xin Tian ◽  
Xinming Li
Keyword(s):  
Cancer Treatment ◽  
Tannic Acid ◽  
Near Infrared ◽  
Shear Thinning ◽  
Injectable Hydrogels ◽  
Injectable Hydrogel ◽  
Promising Strategy ◽  
Photothermal Effects

Developing injectable hydrogels with near-infrared (NIR)-responsive photothermal effects has increasingly become a promising strategy for local cancer treatment via combinational photothermal-chemotherapy. Herein, a biocompatible hydrogel with a remarkable shear-thinning and...

An injectable hydrogel formed by in situ cross-linking of glycol chitosan and multi-benzaldehyde functionalized PEG analogues for cartilage tissue engineering

2015 ◽  
Vol 3 (7) ◽  
pp. 1268-1280 ◽  
Author(s):  
Luping Cao ◽  
Bin Cao ◽  
Chengjiao Lu ◽  
Guowei Wang ◽  
Lin Yu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Cross Linking ◽  
Glycol Chitosan ◽  
Injectable Hydrogels ◽  
Injectable Hydrogel ◽  
Cross Linker ◽  
Aldehyde Groups

A novel PEG analogue, poly(EO-co-Gly)-CHO, that possesses multiple aldehyde groups is designed and synthesized, and then is used as a cross-linker to react with glycol chitosan to create injectable hydrogels.

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