Fundamentals of integrated ferrohydrodynamic cell separation in circulating tumor cell isolation

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Yang Liu ◽  
Wujun Zhao ◽  
Rui Cheng ◽  
Bryana N. Harris ◽  
Jonathan R. Murrow ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Recovery Rate ◽  
Cell Separation ◽  
Circulating Tumor Cell ◽  
Fundamental Theory ◽  
High Recovery ◽  
High Recovery Rate ◽  
Experimental Validations

We present the fundamental theory and experimental validations of an integrated ferrohydrodynamic cell separation (iFCS) method that can isolate circulating tumor cells with a high recovery rate.

scholarly journals Label-free ferrohydrodynamic cell separation of circulating tumor cells

Lab on a Chip ◽  
2017 ◽  
Vol 17 (18) ◽  
pp. 3097-3111 ◽  
Author(s):  
Wujun Zhao ◽  
Rui Cheng ◽  
Brittany D. Jenkins ◽  
Taotao Zhu ◽  
Nneoma E. Okonkwo ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
High Throughput ◽  
Recovery Rate ◽  
Cell Separation ◽  
Label Free ◽  
High Recovery ◽  
High Recovery Rate

A size-based ferrohydrodynamic cell separation (FCS) device capable of enriching intact circulating tumor cells with high throughput and high recovery rate.

scholarly journals ctcRbase: the gene expression database of circulating tumor cells and microemboli

Database ◽  
2020 ◽  
Vol 2020 ◽  
Author(s):  
Lei Zhao ◽  
Xiaohong Wu ◽  
Tong Li ◽  
Jian Luo ◽  
Dong Dong
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cancer Metastasis ◽  
Circulating Tumor Cell ◽  
Gene Signature ◽  
Primary Tumors ◽  
A Genome ◽  
Experimental Validations ◽  
Transcriptomic Changes

Abstract Circulating tumor cells/microemboli (CTCs/CTMs) are malignant cells that depart from cancerous lesions and shed into the bloodstream. Analysis of CTCs can allow the investigation of tumor cell biomarker expression from a non-invasive liquid biopsy. To date, high-throughput technologies have become a powerful tool to provide a genome-wide view of transcriptomic changes associated with CTCs/CTMs. These data provided us much information to understand the tumor heterogeneity, and the underlying molecular mechanism of tumor metastases. Unfortunately, these data have been deposited into various repositories, and a uniform resource for the cancer metastasis is still unavailable. To this end, we integrated previously published transcriptome datasets of CTCs/CTMs and constructed a web-accessible database. The first release of ctcRbase contains 526 CTCs/CTM samples across seven cancer types. The expression of 14 631 mRNAs and 3642 long non-coding RNAs of CTCs/CTMs were included. Experimental validations from the published literature are also included. Since CTCs/CTMs are considered to be precursors of metastases, ctcRbase also collected the expression data of primary tumors and metastases, which allows user to discover a unique ‘circulating tumor cell gene signature’ that is distinct from primary tumor and metastases. An easy-to-use database was constructed to query and browse CTCs/CTMs genes. ctcRbase can be freely accessible at http://www.origin-gene.cn/database/ctcRbase/.

Circulating tumor cell detection using a parallel flow micro-aperture chip system

Lab on a Chip ◽  
2015 ◽  
Vol 15 (7) ◽  
pp. 1677-1688 ◽  
Author(s):  
Chun-Li Chang ◽  
Wanfeng Huang ◽  
Shadia I. Jalal ◽  
Bin-Da Chan ◽  
Aamer Mahmood ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Circulating Tumor Cell ◽  
Parallel Flow ◽  
Cell Detection ◽  
Tumor Cell Detection ◽  
System P

A parallel flow micro-aperture chip system for detection of circulating tumor cells.

scholarly journals Microfluidics-enabled rapid manufacturing of hierarchical silica-magnetic microflower toward enhanced circulating tumor cell screening

2018 ◽  
Vol 6 (12) ◽  
pp. 3121-3125 ◽  
Author(s):  
Nanjing Hao ◽  
Yuan Nie ◽  
Amogha Tadimety ◽  
Ting Shen ◽  
John X. J. Zhang
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Circulating Tumor Cell ◽  
Rapid Manufacturing ◽  
Screening Efficiency

Microfluidics-enabled rapid manufacturing of a hierarchical silica-magnetic microflower was developed for improving the screening efficiency of circulating tumor cells.

scholarly journals Precision microfilters as an all in one system for multiplex analysis of circulating tumor cells

RSC Advances ◽  
2016 ◽  
Vol 6 (8) ◽  
pp. 6405-6414 ◽  
Author(s):  
Daniel L. Adams ◽  
R. Katherine Alpaugh ◽  
Stuart S. Martin ◽  
Monica Charpentier ◽  
Saranya Chumsri ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Circulating Tumor Cell ◽  
Clinical Testing ◽  
Multiplex Analysis

An all-in-one Circulating Tumor Cell (CTC) isolation platform with streamlined multiplex integration of proteomic and genomic clinical testing.

Sign in / Sign up

Export Citation Format

Share Document